The effect of Kö 1173, a new anticonvulsant agent on experimental cardiac arrhythmias

Effects of Tiprenolol, Practolol and Propranolol on Experimental Ventricular Tachyarrhythmias

“…These results contrast with the greater efficacy and lower toxicity of drugs such as lignocaine, mexiletine (Ko 1173) and diphenylhydantoin in concurrent studies (Allen et al, 1971 c;Allen et al, 1972).…”

“…Ventricular arrhythmias were produced in dogs of either sex (weighing 17-35 kg) by methods which have been described in detail (Allen, Shanks & Zaidi, 1971c;Allen, Ekue, Shanks & Zaidi, 1972). When the dogs were anaesthetized, positive pressure respiration was maintained through an endotracheal tube, with a Palmer Ideal pump at a rate of 18 per min, and a tidal volume of 13 ml/kg room air; a catheter was inserted into a foreleg vein.…”

Electrophysiological mechanisms for the antiarrhythmic action of mexiletine on digitalis‐, reperfusion‐ and reoxygenation‐induced arrhythmias

“…Mexiletine has been found to be more active than the parent compound in controlling ventricular tachyarrhythmias following acute myocardial infarction (Horowitz et al, 1981) and to suppress digitalis-induced arrhythmias (Allen et al, 1972). The antiarrhythmic effect of class I drugs is generally referred to as their property of interfering specifically with the sodium channels, an effect which is simply revealed by the reduction of the maximum rate of depolarization ( (Vaughan Williams, 1984).…”

Investigation of the Antifibrillatory Activity of Some Anticonvulsant Γ‐aminobutyric Acid‐transaminase Inhibitors in the Rabbit Isolated Heart: Comparison With Phenytoin and Mexiletine

“…Subsequently, phenytoin has been proved to be effective in correcting various experimental and clinical arrhythmias (see review by Dreifus & Watanabe, 1970) and has gained wide clinical use. Mexiletine (Ko 1173) is another example of a drug originally introduced as an anticonvulsant agent but in subsequent studies found to be effective in suppressing ventricular arrhythmias both in experimental animals (Allen, Kofi Ekue, Shanks & Zaidi, 1972) and in man (Talbot, Clark, Nimmo, Neilson, Julian & Prescott, 1973). In recent years, compounds such as amino-oxyacetic acid (Murakami, Abe & Murakami, 1976) and sodium valproate (Simler, Ciesielski, Maitre, Randrianarisoa & Mandel, 1973) have been found to possess anticonvulsant action, an effect which was partly attributed to their action of elevating brain levels of the inhibitory transmitter, y-aminobutyric acid (GABA).…”