The effect of ketamine on the MACBAR of sevoflurane in dogs

Love, Lydia; Egger, Christine; Rohrbach, Barton W; Cox, Sherry; Hobbs, Meredith; Doherty, Thomas J

doi:10.1111/j.1467-2995.2011.00616.x

Cited by 25 publications

(18 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results from the canine study by Wilson et al are quite similar to those in the present study. A composition of gender in dogs is a great difference in experimental protocol between the present study (all intact female dogs) and the study reported by Love et al [14] (all intact male dogs). Gender difference in the MAC-BAR was supposed in human patients [11,24].…”

contrasting

confidence: 52%

“…In the present study, the sevoflurane MAC-BAR for the dogs was 3.33 ± 0.48%, which is somewhat higher than the sevoflurane MAC-BAR (2.77%) for intact male mixedbreed dogs recently reported by Love et al [14]. Love et al [14] mentioned that their sevoflurane MAC-BAR was lower than expected value based on a previous canine study using the same methodology, documented a sevoflurane MAC-BAR of 3.21% and a MAC of 1.93% (Wilson et al 2008.…”

mentioning

confidence: 71%

“…Love et al [14] mentioned that their sevoflurane MAC-BAR was lower than expected value based on a previous canine study using the same methodology, documented a sevoflurane MAC-BAR of 3.21% and a MAC of 1.93% (Wilson et al 2008. Determination of MAC and MAC derivatives for isoflurane and sevoflurane.…”

mentioning

confidence: 99%

“…Because the cardiovascular depression produced by sevoflurane is dosedependent in dogs, the concentrations required for blocking the autonomic response can generate considerable cardiovascular instability. Analgesic drugs will reduce the MAC-BAR for volatile anesthetic agents [7,14]. Therefore, it may be preferable to combine sevoflurane with adjunctive analgesics, such as opioids, non-steroidal anti-inflammatory drugs, ketamine, and local blocks using local anesthetics in order to diminish the hemodynamic consequences of high doses of sevoflurane by decreasing the MAC-BAR to clinically relevant concentrations.…”

mentioning

confidence: 99%

“…The MAC and MAC-BAR of sevoflurane were determined by judging the dogs' response to a noxious electrical stimulus (50 V, 50 Hz, 10 msec) [14] applied to their right upper gingival. After the dogs were allowed to equilibrate for 60 min at ETSEV 2.8 to 3.0%, the electrical stimulus was applied for 10 sec using an electrical stimulator (SEN3301, Nihon Kohden Co., Tokyo, Japan).…”

mentioning

confidence: 99%

See 4 more Smart Citations

Minimum Alveolar Concentration for Blunting Adrenergic Responses (MAC-BAR) of Sevoflurane in Dogs

et al. 2012

View full text Add to dashboard Cite

ABSTRACT. It is well known that heart rate or arterial blood pressure may increase in response to surgical stimulation despite the absence of a purposeful movement. However, there is limited information regarding anesthetic requirement for blunting adrenergic response in dogs. This study was designed to compare the minimum alveolar concentrations of sevoflurane required to prevent autonomic response (MAC-BAR) and purposeful movement (MAC) in dogs. Sevoflurane MAC-BAR and MAC were determined in 5 beagle dogs by judging dogs' response to a noxious electrical stimulus applied to the gingiva. The sevoflurane MAC-BAR was significantly higher than MAC (3.33 ± 0.48 vs 2.10 ± 0.28%, P=0.005). These results suggested that autonomic responses occurred at sevoflurane anesthetic concentrations at which purposeful movements were absent.

show abstract

contrasting

confidence: 52%

mentioning

confidence: 71%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations