The effect of kaempferol on the dentin bonding stability through matrix metalloproteinases inhibition and collagen crosslink in dentin biomodification

Cho, Jeonghwa; Kim, Hyeryeong; Yoo, Kyung-Hyeon; Paik, Youna; Kim, In‐Ryoung; Yoon, Soon-Do; Kim, Yong‐Il

doi:10.1016/j.jds.2022.12.002

Cited by 3 publications

(3 citation statements)

References 40 publications

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“…The results suggest that the kaempferol treatment group exhibited a higher bond strength than the control group after thermocycling. Furthermore, the FTIR analysis showed that the kaempferol group had a significantly greater PO4 peak than the control group, indicating a stronger cross-link between dentin and collagen [139]. The potential role of dental health is shown in Figure 6.…”

Section: Role In Dental Healthmentioning

confidence: 98%

Pharmacological Potential of Kaempferol, a Flavonoid in the Management of Pathogenesis via Modulation of Inflammation and Other Biological Activities

Alrumaihi,

Almatroodi,

Alharbi

et al. 2024

Molecules

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Natural products and their bioactive compounds have been used for centuries to prevent and treat numerous diseases. Kaempferol, a flavonoid found in vegetables, fruits, and spices, is recognized for its various beneficial properties, including its antioxidant and anti-inflammatory potential. This molecule has been identified as a potential means of managing different pathogenesis due to its capability to manage various biological activities. Moreover, this compound has a wide range of health-promoting benefits, such as cardioprotective, neuroprotective, hepatoprotective, and anti-diabetic, and has a role in maintaining eye, skin, and respiratory system health. Furthermore, it can also inhibit tumor growth and modulate various cell-signaling pathways. In vivo and in vitro studies have demonstrated that this compound has been shown to increase efficacy when combined with other natural products or drugs. In addition, kaempferol-based nano-formulations are more effective than kaempferol treatment alone. This review aims to provide detailed information about the sources of this compound, its bioavailability, and its role in various pathogenesis. Although there is promising evidence for its ability to manage diseases, it is crucial to conduct further investigations to know its toxicity, safety aspects, and mechanism of action in health management.

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Section: Role In Dental Healthmentioning

confidence: 98%

Pharmacological Potential of Kaempferol, a Flavonoid in the Management of Pathogenesis via Modulation of Inflammation and Other Biological Activities

Alrumaihi,

Almatroodi,

Alharbi

et al. 2024

Molecules

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show abstract

“…Natural polyphenols, such as proanthocyanidins (PA), 13 quercetin, 14 catechins, 15 myricetin, 16 resveratrol, 17 and kaempferol 18 contain multiple phenolic -OH groups, which can form hydrogen bonds with collagen amide carbonyl groups to modify the collagen and inhibit MMPs. These -OH groups at the free end can also chelate with metal cations (e g, Ca 2+ , Mg 2+ , and Au 2+ ), thereby potentially accelerating ACP nanoparticle deposition and HA formation.…”

Section: Introductionmentioning

confidence: 99%

“…[19][20][21][22] PA has been shown to have positive effects on dentin remineralization. [23][24][25] In the past 3 years, the clinical value of myricetin, resveratrol, and kaempferol has gradually increased, and these polyphenols have been proven to improve the resin-dentin bonding durability by modifying collagen and inhibiting MMP activity; [16][17][18] however, their contribution to biomimetic remineralization remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Polyphenols Can Improve Resin-Dentin Bond Durability by Promoting Amorphous Calcium Phosphate Nanoparticles to Backfill the Dentin Matrix

Wang¹,

Han²,

You³

et al. 2023

IJN

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Objective To investigate the effects of proanthocyanidins (PA), myricetin, resveratrol, and kaempferol on the modification of dentin collagen and the inhibition of matrix metalloproteinase (MMP) activity, and to evaluate their contributions to the biomimetic remineralization and resin-dentin bonding performance. Methods Attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and in situ zymography were applied to verify the collagen modification and MMP activity inhibition induced by these four polyphenols. Scanning electron microscopy/energy dispersive spectrometer (SEM/EDS) analysis, X-ray diffraction (XRD), ATR-FTIR, Vickers hardness numbers (VHN), and micro-computed tomography (micro-CT) were performed to characterize the remineralized dentin. Microtensile bond strength (μTBS) and nanoleakage were investigated to evaluate the effects of the four polyphenols on resin-dentin bonding durability. Results ATR-FTIR and in situ zymography confirmed that these four polyphenols could modify dentin collagen and inhibit MMP activity, respectively. Chemoanalytic characterization exhibited the efficacies of the four polyphenols in promoting dentin biomimetic remineralization. The surface hardness of PA-pretreated dentin was the greatest. Micro-CT results demonstrated that the PAs group possessed the highest amount of dentin surface minerals and the lowest amount of deep-layer minerals. The surface and deep-layer mineral contents of the Myr group were higher than Res and Kae groups. Treatment with these four polyphenols significantly increased the initial μTBS compared with the control group without primer conditioning. μTBS decreased significantly during aging, and the decrease was more severe in the PAs and Kae groups than in the Myr and Res groups. With or without aging, the polyphenol groups exhibited relatively less fluorescence. However, the Myr and Res groups showed less serious nanoleakage after aging. Conclusion PA, myricetin, resveratrol, and kaempferol can modify dentin collagen, inhibit MMP activity, promote biomimetic remineralization, and improve resin-dentin bond durability. Compared with PA and kaempferol, myricetin and resveratrol are more effective in improving resin-dentin bonding.

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A comparison of different cleaning approaches for blood contamination after curing universal adhesives on the dentine surface

Liu,

Xie,

Chen

2024

Dental Materials

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The effect of kaempferol on the dentin bonding stability through matrix metalloproteinases inhibition and collagen crosslink in dentin biomodification

Cited by 3 publications

References 40 publications

Pharmacological Potential of Kaempferol, a Flavonoid in the Management of Pathogenesis via Modulation of Inflammation and Other Biological Activities

Pharmacological Potential of Kaempferol, a Flavonoid in the Management of Pathogenesis via Modulation of Inflammation and Other Biological Activities

Polyphenols Can Improve Resin-Dentin Bond Durability by Promoting Amorphous Calcium Phosphate Nanoparticles to Backfill the Dentin Matrix

A comparison of different cleaning approaches for blood contamination after curing universal adhesives on the dentine surface

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