The effect of kaempferol and apigenin on allogenic synovial membrane-derived stem cells therapy in knee osteoarthritic male rats

Estakhri, Firoozeh; Panjehshahin, Mohammad Reza; Tanideh, Nader; Gheisari, Rasoul; Mahmoodzadeh, Amir; Azarpira, Negar; Gholijani, Nasser

doi:10.1016/j.knee.2020.03.005

Cited by 30 publications

(27 citation statements)

References 56 publications

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“…Similarly, kaempferol showed significant effects of decreasing skin fibrosis and downstream oxidative biomarkers [ 60 ]. When tested in male rats with knee osteoarthritis (OA) in a model of ACLT-induced OA, in combination with apigenin, it strongly improved the OA [ 61 ].…”

Section: Anti-inflammatory Effect Of Kaempferolmentioning

confidence: 99%

Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing

et al. 2020

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Inflammation is a physiological response to different pathological, cellular or vascular damages due to physical, chemical or mechanical trauma. It is characterized by pain, redness, heat and swelling. Current natural drugs are carefully chosen as a novel therapeutic strategy for the management of inflammatory diseases. Different phytochemical constituents are present in natural products. These phytochemicals have high efficacy both in vivo and in vitro. Among them, flavonoids occur in many foods, vegetables and herbal medicines and are considered as the most active constituent, having the ability to attenuate inflammation. Kaempferol is a polyphenol that is richly found in fruits, vegetables and herbal medicines. It is also found in plant-derived beverages. Kaempferol is used in the management of various ailments but there is no available review article that can summarize all the natural sources and biological activities specifically focusing on the anti-inflammatory effect of kaempferol. Therefore, this article is aimed at providing a brief updated review of the literature regarding the anti-inflammatory effect of kaempferol and its possible molecular mechanisms of action. Furthermore, the review provides the available updated literature regarding the natural sources, chemistry, biosynthesis, oral absorption, metabolism, bioavailability and therapeutic effect of kaempferol.

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Section: Anti-inflammatory Effect Of Kaempferolmentioning

confidence: 99%

Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing

et al. 2020

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“…[53] (in vitro) Through HPLC, the composition of LI73014F2 was determined to be gallic acid (18 mg/g), total curcuminoids (35 mg/g), and AKBA (9 mg/g). Through HPLC, the composition of LI73014F2 was determined to be gallic acid (18 mg/g), total curcuminoids (35 mg/g), and AKBA (9 mg/g [54] (in vivo) -ACTL-induced OA in Sprague Dawley rats (6 groups, n = 10/group); 1. Νο ACLT, 2.…”

Section: Astragalus Membranaceus and Lithospermum Erythrorhizon Extracts (Alm16)mentioning

confidence: 99%

“…The effect of two flavonoids, kaempferol and apigenin, in combination with MSCs on anterior cruciate ligament transection (ACLT)-induced OA in rats, was investigated in a recent study [ 54 ]. After treatment of synovial membrane-derived MSCs (SMMSCs) with the two flavonoids for evaluation of cell viability, concentrations of 10 μM and 20 μM for kaempferol and 0.1 μM and 0.3 μM for apigenin were selected for the experiments.…”

Section: Preclinical and Clinical Studiesmentioning

confidence: 99%

Dietary Interventions with Polyphenols in Osteoarthritis: A Systematic Review Directed from the Preclinical Data to Randomized Clinical Studies

et al. 2021

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Osteoarthritis (OA) is the most common form of arthritis and a major cause of limited functionality and thus a decrease in the quality of life of the inflicted. Given the fact that the existing pharmacological treatments lack disease-modifying properties and their use entails significant side effects, nutraceuticals with bioactive compounds constitute an interesting field of research. Polyphenols are plant-derived molecules with established anti-inflammatory and antioxidant properties that have been extensively evaluated in clinical settings and preclinical models in OA. As more knowledge is gained in the research field, an interesting approach in the management of OA is the additive and/or synergistic effects that polyphenols may have in an optimized supplement. Therefore, the aim of this review was to summarize the recent literature regarding the use of combined polyphenols in the management of OA. For that purpose, a PubMed literature survey was conducted with a focus on some preclinical osteoarthritis models and randomized clinical trials on patients with osteoarthritis from 2018 to 2021 which have evaluated the effect of combinations of polyphenol-rich extracts and purified polyphenol constituents. Data indicate that combined polyphenols may be promising for the treatment of osteoarthritis in the future, but more clinical trials with novel approaches in the identification of the in-between relationship of such constituents are needed.

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“…Pan et al [ 53 ] found that baicalin can reduce oxidative stress and apoptosis in endplate-H 2 O 2- induced chondrocytes. In another study, kaempferol, apigenin, and synovial membrane derived stem cells (SMMSCs) injected into the joints of OA rats increased SOD levels in the cartilage homogenate and decreased MDA levels [ 54 ]. In addition, Zhou et al [ 55 ] found that isorhamnetin can reduce ROS production induced by RANKL and protect chondrocytes from oxidative stress, which leads to apoptosis.…”

Section: Mechanisms Of Action Of Natural Products In Oa Treatmentmentioning

confidence: 99%

Research Progress on the Antiosteoarthritic Mechanism of Action of Natural Products

Gao

Chen

Zhang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Osteoarthritis (OA) is a clinical joint degenerative disease, the pathogenic factors of which include age, obesity, and mechanical injury. Its main pathological features include cartilage loss, narrowing of joint space, and osteophyte formation. At present, there are a variety of treatment methods for OA. Natural products, which are gradually being applied in the treatment of OA, are advantageous as they present with low toxicity and low costs and act on multiple targets. Methods. The terms “natural products,” “osteoarthritis,” and “chondrocytes” were searched in PubMed to screen the related literature in the recent 10 years. Results. We comprehensively introduced 62 published papers on 48 natural products involving 6, 3, 5, 12, 4, and 5 kinds of terpenoids, polysaccharides, polyphenols, flavonoids, alkaloids, and saponins, respectively (and others). Conclusion. The mechanisms of their anti-OA action mainly involve reducing the production of inflammatory factors, reducing oxidative stress, regulating the metabolism of chondrocytes, promoting the proliferation of chondrocytes, or inhibiting chondrocyte apoptosis. This article summarizes the anti-OA activity of natural products in the last 10 years and provides candidate monomers for further study for use in OA treatment.

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The effect of kaempferol and apigenin on allogenic synovial membrane-derived stem cells therapy in knee osteoarthritic male rats

Cited by 30 publications

References 56 publications

Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing

Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing

Dietary Interventions with Polyphenols in Osteoarthritis: A Systematic Review Directed from the Preclinical Data to Randomized Clinical Studies

Research Progress on the Antiosteoarthritic Mechanism of Action of Natural Products

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