The effect of isolated soy protein adjunctive with flaxseed oil on markers of inflammation, oxidative stress, acute phase proteins, and wound healing of burn patients; a randomized clinical trial

Soy Protein/Cellulose Nanofiber Scaffolds Mimicking Skin Extracellular Matrix for Enhanced Wound Healing

“…In line with our in vitro results, the in vivo data supported our hypothesis that both a nanofibrous architecture and bioactive soy protein accelerated wound closure and supported regeneration of the dermal and epidermal layers. These observation also corroborate previously published results in which ECM-mimetic peptide [9c, 13b] and phytoestrogens [8c, 45] in soy protein promoted re-epithelialization and dermal tissue regeneration. When comparing our results to other reports of pro-regenerative fibrous scaffolds that consist of natural materials (such as ECM proteins, silk, and chitosan), [46] similar trends can be established for both wound closure rate and tissue regeneration (re-epithelialization, epidermal thinning, collagen alignment, and scar formation).…”

“…[3, 9b, 9c] Soy phytoestrogens have demonstrated to accelerate the healing process via ER-mediated signaling pathways. [8b, 8c, 10] They also possess anti-bacterial, [2b, 11] anti-inflammatory, [12] and anti-oxidant properties [13] that support and enhance wound healing. Moreover, clinical trials have reported that oral intake of soy (both protein and phytoestrogens) accelerates skin regeneration in aged women and burn patients.…”

“…Moreover, clinical trials have reported that oral intake of soy (both protein and phytoestrogens) accelerates skin regeneration in aged women and burn patients. [13b, 14] …”

Long-term vitamin D and high-dose n-3 fatty acids’ supplementation improve markers of cardiometabolic risk in type 2 diabetic patients with CHD

“…The consumption of flaxseed reduced inflammatory markers in patients with coronary artery disease (50) . Furthermore, taking flaxseed oil with isolated soya protein for 3 weeks lowered blood CRP values in burn patients (51) . Although in another study, 6-week supplementation with flaxseed oil (containing 3•5 g α-linolenic acid) did not affect hs-CRP levels in polycystic ovary syndrome patients (52) .…”

Effect of small molecular weight soybean protein-derived peptide supplementation on attenuating burn injury-induced inflammation and accelerating wound healing in a rat model

“…21 More specically, in a randomized trial, nutritional supplements with isolated soy protein were observed to decreased inammatory and oxidative stress responses and improve wound healing in burn patients. 22 Nevertheless, there are still disadvantages to limit the development of isolated soy protein supplements, such as solubility and absorption. In addition, optimized soybean protein-derived peptides obtained by enzymatic hydrolysis and physical modications, combined with ultraltration membrane separation and reversed micelle extraction of soybean proteins, 23 may better regulate burn-induced inammatory responses, due to the improved equilibrium of the essential amino acids, increased solubility, faster absorption rate and lower cost, and are more suitable for clinical oral nutritional supplementation (ONS).…”