The effect of irradiation on the biodistribution of radiolabeled pegylated liposomes

Harrington, Kevin J.; Rowlinson-Busza, Gail; Syrigos, Konstantinos; Uster, Paul S.; Vile, Richard G.; Peters, A. M.; Stewart, J.S.W.

doi:10.1016/s0360-3016(01)01508-5

Cited by 25 publications

(28 citation statements)

References 31 publications

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“…Each organ was then weighed, and samples were analyzed for 111 In activity using a PerkinElmer (Packard) Cobra II gamma counter. Chelation of 111 In with DTPA and other chelating agents form very stable complexes that are commonly used for in vivo biodistribution studies of various therapeutic molecules and their delivery systems (45)(46)(47). The stability constant between DTPA and 111 In has been determined by others to be 1.5 ϫ 10 29 (48), and previous studies have shown that the [ 111 In]-DTPA ligand has a strong chelating effect on the radiometal in human serum (44).…”

Section: Methodsmentioning

confidence: 99%

Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers

Singh

Pantarotto

Lacerda

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

974

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Carbon nanotubes (CNT) are intensively being developed for biomedical applications including drug and gene delivery. Although all possible clinical applications will require compatibility of CNT with the biological milieu, their in vivo capabilities and limitations have not yet been explored. In this work, water-soluble, singlewalled CNT (SWNT) have been functionalized with the chelating molecule diethylentriaminepentaacetic (DTPA) and labeled with indium ( 111 In) for imaging purposes. Intravenous (i.v.) administration of these functionalized SWNT (f-SWNT) followed by radioactivity tracing using gamma scintigraphy indicated that f-SWNT are not retained in any of the reticuloendothelial system organs (liver or spleen) and are rapidly cleared from systemic blood circulation through the renal excretion route. The observed rapid blood clearance and half-life (3 h) of f-SWNT has major implications for all potential clinical uses of CNT. Moreover, urine excretion studies using both f-SWNT and functionalized multiwalled CNT followed by electron microscopy analysis of urine samples revealed that both types of nanotubes were excreted as intact nanotubes. This work describes the pharmacokinetic parameters of i.v. administered functionalized CNT relevant for various therapeutic and diagnostic applications.nanomedicine ͉ blood circulation half-life ͉ drug delivery ͉ pharmacokinetics ͉ nanotoxicology

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Section: Methodsmentioning

confidence: 99%

Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers

Singh

Pantarotto

Lacerda

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

974

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“…In general, both in animal models and in patients, rapidly growing and highly vascularized tumors tend to be more permeable than slowly growing and poorly vascularized tumors, thereby making them more prone to EPR-mediated passive drug targeting. This can be exemplified by taking into account that Kaposi sarcoma tumors, which are known to be highly vascularized and highly leaky, accumulate longcirculating liposomes very efficiently 15 , and respond very well to treatment with Doxil, doubling response rates as compared to the triple chemotherapy combination Adriamycin (Doxorubicin), Bleomycin and Vincristine 16 . Vice versa, patients suffering from lesspermeable tumors, such as the vast majority of breast carcinomas 15 , did not really benefit from Doxil vs. free doxorubicin treatment.…”

mentioning

confidence: 99%

“…This can be exemplified by taking into account that Kaposi sarcoma tumors, which are known to be highly vascularized and highly leaky, accumulate longcirculating liposomes very efficiently 15 , and respond very well to treatment with Doxil, doubling response rates as compared to the triple chemotherapy combination Adriamycin (Doxorubicin), Bleomycin and Vincristine 16 . Vice versa, patients suffering from lesspermeable tumors, such as the vast majority of breast carcinomas 15 , did not really benefit from Doxil vs. free doxorubicin treatment. Progression-free and overall survival times were found to be similar for the liposomal and the free drug, but the toxicity profile was beneficially affected, with less bone marrow depression, alopecia, nausea and vomiting, and with a shift of the dose-limiting toxicity from cumulative cardiomyopathy for free doxorubicin to hand-and-foot syndrome for Doxil [16][17][18] .…”

mentioning

confidence: 99%

Passive versus Active Tumor Targeting Using RGD- and NGR-Modified Polymeric Nanomedicines

et al. 2014

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Enhanced permeability and retention (EPR), and the (over-) expression of angiogenesis-related surface receptors are key features of tumor blood vessels. As a consequence, EPR-mediated passive and RGD-and NGR-based active tumor targeting have received considerable attention in the last couple of years. Using several different in vivo and ex vivo optical imaging techniques, we here visualized and quantified the benefit of RGD-and NGR-based vascular vs. EPR-mediated passive tumor targeting. This was done using ~10 nm-sized polymeric nanocarriers, which were either labeled with DY-676 (peptide-modified polymers) or with DY-750 (peptide-free polymers). Upon co-injection into mice bearing both highly leaky CT26 and poorly leaky BxPC3 tumors, it was found that vascular targeting did work, resulting in rapid and efficient early binding to tumor blood vessels, but that over time, passive targeting was significantly more efficient, leading to higher overall levels and to more efficient retention within tumors. Although this situation might be different for larger carrier materials, these insights indicate that caution should be taken not to over-estimate the potential of active over passive tumor targeting. KeywordsNanomedicine; Drug targeting; EPR; RGD; NGR Paralleled by the ever-increasing advances in nanotechnology and chemical engineering, nanomedicine formulations have started to attract significant attention in the last couple of years. Nanomedicines are 1-100(0) nm-sized carrier materials designed to improve the biodistribution and target site accumulation of low-molecular-weight (chemo-) therapeutic agents. By means of both passive and active targeting mechanisms, nanocarrier materials * Corresponding Authors Prof. Dr. Fabian Kiessling; Tel: +49-241-8080116; fkiessling@ukaachen.de Dr. Dr. Twan Lammers; Tel: +49-241-8036681; tlammers@ukaachen.de. Supporting Information Materials and methods describing the synthesis and characterization of the polymeric nanocarriers are provided as supplementary information. This material is available free of charge via the Internet at http://pubs.acs.org. Europe PMC Funders GroupAuthor Manuscript Nano Lett. Author manuscript; available in PMC 2014 March 04. Published in final edited form as:Nano Lett. 2014 February 12; 14(2): 972-981. doi:10.1021/nl404391r. Europe PMC Funders Author ManuscriptsEurope PMC Funders Author Manuscripts aim to more efficiently deliver drug molecules to pathological sites, while at the same time preventing their accumulation in potentially endangered healthy tissues, thereby beneficially affecting the balance between their efficacy and toxicity 1-4 .Passive drug targeting relies on the hyper-permeable tumor vasculature. Endothelial gaps and improperly aligned vascular endothelium result in leaky blood vessels, which enable the extravasation of carrier materials with sizes of up to several 100's of nm into the tumor interstitium. In addition to this, dysfunctional lymphatic drainage results in the retention of extravasated nanomaterials within tumo...

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“…In addition, preferential accumulation of liposomes and polymeric NPs at the disease sites, as the result of passive targeting through enhanced permeability and retention (EPR) effect and active targeting through selected surface ligands, has been extensively explored [39,40]. As a result, a number of approved therapeutics based on liposomes and polymeric NPs have entered clinical use, and more are under various stages of clinical development [41][42][43][44].…”

Section: Polymeric-based Core-shell Colloidmentioning

confidence: 99%

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

Contreras-García¹,

Bucio²

2013

Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering

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By definition, nanomaterials are multifunctional due to the co-incorporation of both therapeutic and bioimaging agents. Among the therapeutic applications of the polymeric nanomaterials are found drug, protein or gene delivery, tissue engineering. Other advances in bioapplications include cell-labeling, cell membrane modeling, agent delivery and targeting. Additionally, imaging nanobiotechnology is applied to sensorization and diagnosis with biosensors and biomarkers for biodetection and bioimaging, respectively. In this chapter are described the different polymeric nanostructures applied to therapy and diagnosis such as polymeric-based core-shell colloid, proteins and peptides, drug conjugates and complexes with synthetic polymers, dendrimers, vesicles, micelles, carbon nanotubes, biopolymers, smart nano polymers, metal-polymer complexes, enzyme-responsive nanoparticles, and hybrid polymeric nanomaterials. The different types of polymers are fabricated using several approaches ranging from conventional chemical methods to more sophisticated processes such as surface modification using ionizing radiation to obtain layers free of pollutants without purification and isolation processes among other advantages.

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The effect of irradiation on the biodistribution of radiolabeled pegylated liposomes

Cited by 25 publications

References 31 publications

Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers

Tissue biodistribution and blood clearance rates of intravenously administered carbon nanotube radiotracers

Passive versus Active Tumor Targeting Using RGD- and NGR-Modified Polymeric Nanomedicines

Multifunctional Polymeric Nanostructures for Therapy and Diagnosis

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