The effect of iron status on vascular health

Yunker, Leanne M; Conradson, H.; Faris, Peter; Bridge, Peter J.; Buithieu, Jean; Title, Lawrence M.; Charbonneau, François; Verma, Subodh; Lonn, Eva; Anderson, Todd J.

doi:10.1191/1358863x06vm656oa

Cited by 16 publications

(9 citation statements)

References 30 publications

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“…Because Fe content in the Asian dietary pattern is lower than that in the Western dietary pattern ( 30 – 32 ) , serum ferritin concentrations in Asian people is expected to be lower than that in Western people. However, serum ferritin concentrations measured in Asian members of our study group were similar to those reported for Western people in other studies ( 24 – 26 ) . Still, the precise reason for the similarity between groups remains unclear.…”

Section: Discussionsupporting

confidence: 90%

Increased serum ferritin levels are independently associated with carotid atherosclerosis in women

Yan-qi

et al. 2017

Br J Nutr

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Previous studies have supported the theory that there is a positive association between ferritin and carotid atherosclerosis in Western people. Diet plays an important role in determining serum ferritin concentration. Asian dietary patterns are different from Western dietary patterns, implying that there may be a difference in the association of ferritin with carotid atherosclerosis between Asian and Western people. However, few studies focus on the association between ferritin and carotid atherosclerosis among Asians. The aim of this study was to investigate how serum ferritin levels are associated with carotid atherosclerosis in an Asian adult population. A cross-sectional assessment was performed in 8302 adults in Tianjin, China. Carotid intima-media thickness (IMT) and plaques were assessed using ultrasonography, and serum ferritin was measured using the protein chip-chemiluminescence method. Multiple logistic regression analysis was used to examine the association between quartiles of serum ferritin concentration and carotid atherosclerosis. In the present study, the overall prevalence of IMT and carotid plaques in participants is 29·2 and 22·7 %, respectively. In women, after adjustments for potentially confounding factors, the OR of IMT and carotid plaques by increasing serum ferritin quartiles were 1·00, 1·39 (95 % CI 0·98-1·99), 1·39 (95 % CI 0·99-1·97), 1·81 (95 % CI 1·30-2·55) (P for trend<0·001) and 1·00, 1·24 (95 % CI 0·89-1·73), 1·18 (95 % CI 0·85-1·65), 1·59 (95 % CI 1·15-2·20) (P for trend<0·01), respectively. However, no association was found between serum ferritin and carotid atherosclerosis in men. The study demonstrated that increased serum ferritin levels are independently associated with IMT and carotid plaques in Asian women but not in Asian men.

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Section: Discussionsupporting

confidence: 90%

Increased serum ferritin levels are independently associated with carotid atherosclerosis in women

Yan-qi

et al. 2017

Br J Nutr

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“…24,25 In contrast, Yunker et al found no association between serum ferritin and carotid atherosclerosis. 26 To date, only three studies have examined the associations between serum ferritin level and arterial stiffness, which is another marker for subclinical atherosclerosis. A study conducted by Lee et al indicated that ferritin was independently associated with arterial stiffness in healthy subjects even after adjusting for age, sex, and blood pressure, but this association was positive only in women and was in fact negative in men.…”

Section: Discussionmentioning

confidence: 99%

Serum ferritin levels are associated with arterial stiffness in healthy Korean adults

Kim

Kang

et al. 2016

Vasc Med

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Although an association between serum ferritin and atherosclerosis has been suggested, limited epidemiologic data are available regarding the association between ferritin and arterial stiffness in healthy adults. A total of 2932 healthy subjects were enrolled in this study. Anthropometric and biochemical profiles including ferritin were measured. The arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). Serum ferritin levels were classified into quartiles and baPWV values gradually increased with each ferritin quartile. Multiple regression analysis showed that ferritin levels were independently correlated with baPWV. After adjusting for multiple risk factors, as compared with the lowest quartile, the odds ratios for high baPWV (>75(th) percentile) were 1.15 (0.84-1.56), 1.37 (0.97-1.73), and 1.46 (1.29-2.17) among men (p for trend < 0.05) and 1.24 (0.87-1.79), 1.53 (1.09-2.16), and 1.80 (1.25-2.82) among women (p for trend < 0.05), for the second, third, and fourth quartiles of ferritin, respectively. In conclusion, serum ferritin levels are independently associated with arterial stiffness in healthy Korean adults.

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“…However, the majority of the studies disagreed with these results [ 61 , 79 – 89 ]. Indeed, Bozzini et al [ 61 ] found a similar rate of carriers of C282Y mutation among patients with coronary atherosclerotic disease and controls.…”

Section: Iron Overload and Thrombosismentioning

confidence: 99%

“…Similarly, in the West of Scotland Coronary Prevention Study (WOSCOPS), Gunn et al [ 86 ] found that the presence of a C282Y mutation in the HFE gene did not predict the occurrence of coronary events over a mean follow-up of 4.9 years. It is interesting to note that Yunker et al [ 89 ] analyzed the relationship between biochemical and genetic markers of iron overload and carotid intima-media thickness and brachial flow-mediated vasodilation by high-resolution ultrasound in 907 males, but neither ferritin nor hemochromatosis genotype were related to brachial endothelial function and carotid atherosclerosis. In addition, a recent large study from Denmark found no increased risk of coronary heart disease among carriers of the C282Y mutation or individuals who had compound heterozygosity for the C282Y and H63D mutations [ 79 ].…”

Section: Iron Overload and Thrombosismentioning

confidence: 99%

Iron and thrombosis

et al. 2007

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Although essential for cell physiology, an increase or depletion of body iron has harmful effects on health. Apart from iron deficiency anemia and iron overload-related organ tissue damage, there are increasing evidences that body iron status is implicated in atherosclerotic cardiovascular diseases. The hypothesis formulated in 1981 that iron depletion may protect against cardiovascular events is intriguing and has generated a significant debate in the last two decades. Indeed, to study this phenomenon, several investigators have tried to design appropriate experimental and clinical studies and to identify useful biochemical and genetic markers of iron status. The results of the literature on the effect of iron deficiency and overload on vascular health are critically reviewed in this study from a pathogenic and clinical point of view.

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The effect of iron status on vascular health

Cited by 16 publications

References 30 publications

Increased serum ferritin levels are independently associated with carotid atherosclerosis in women

Increased serum ferritin levels are independently associated with carotid atherosclerosis in women

Serum ferritin levels are associated with arterial stiffness in healthy Korean adults

Iron and thrombosis

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