1999
DOI: 10.4269/ajtmh.1999.60.392
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The effect of iron on the toxigenicity of Vibrio cholerae.

Abstract: Abstract. In vitro and in vivo studies were conducted to assess the response of cholera toxin (CT) production to increasing iron concentrations in an aquatic environment. Production of CT by seven of eight Vibrio cholerae strains tested, including the Bengal strain (O139), was significantly enhanced in the presence of iron concentrations of 1.0 and 10 g/L. The exception (El Tor Ogawa) had a significant CT response only in the presence of 10 g of iron/L. Enhancement of CT production also occurred at iron concen… Show more

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Cited by 6 publications
(4 citation statements)
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References 29 publications
(19 reference statements)
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“…Iron is essential for the growth of several microbes (28), including the oyster parasite P. marinus (6), and for the pathogenicity of certain vibrios (21). Thus, the stressinduced secretion of NA may lead to a release of iron from oyster iron-chelating proteins and promote the replication and/or pathogenicity of V. splendidus in infected oysters.…”
Section: Discussionmentioning
confidence: 99%
“…Iron is essential for the growth of several microbes (28), including the oyster parasite P. marinus (6), and for the pathogenicity of certain vibrios (21). Thus, the stressinduced secretion of NA may lead to a release of iron from oyster iron-chelating proteins and promote the replication and/or pathogenicity of V. splendidus in infected oysters.…”
Section: Discussionmentioning
confidence: 99%
“…Expression of CT is optimal at salinities between 2 and 2.5‰, independent of cell concentration (151). Furthermore, moderate levels of introduced iron also increase the expression of CT (125). Therefore, environmental triggers may become epidemiologically important for prevalence of the organism and its virulence (potentially resulting in shorter onset times and lower infectious doses).…”
Section: Seasonalitymentioning
confidence: 99%
“…In contrast, the blood and liver of mice injected with the nonvirulent strain contained relatively few bacteria. The numbers of nonvirulent E. coli present in the liver 4 h after ip injection with or without hemoglobin were for the entire liver and 6 1 ‫ע‬ 0.4 ϫ 10 3 ‫ע‬ ( ; ) for the virulent strains. 9 1.5 ϫ 10 n p 4 P p .002…”
Section: Resultsmentioning
confidence: 99%
“…Other explanations for this effect have included iron-dependent production of cytotoxins or leukotoxins by the virulent strains [5,6] and the preferential stimulation of growth of virulent strains due to the provision of iron, a nutrilite that is practically unavailable in normal mammalian body fluids [1,7,8]. In this regard, the action of siderophores that permit bacterial iron acquisition in low iron environments has been studied well and can be a virulence factor [9].…”
mentioning
confidence: 99%