The effect of iron deficiency anemia on wound healing

Macon, William L.; Pories, W.J.

doi:10.1097/00006534-197110000-00064

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is plausible that hepcidin, an inhibitor of intestinal iron absorption and activator of iron sequestration by macrophages, is a mediator as it is directly correlated with the degree of obesity and indirectly correlated with iron absorption [ 148 , 164 , 165 ]. Iron is also required in the hydroxylation of lysine and proline; therefore, insufficiencies of this element can lead to decreased tensile strength in wounds [ 166 , 167 ]. Additionally, decreased iron absorption may result in iron deficiency anemia.…”

Section: Discussionmentioning

confidence: 99%

Obesity and Surgical Wound Healing: A Current Review

et al. 2014

View full text Add to dashboard Cite

Objective. The correlation between obesity and deficient wound healing has long been established. This review examines the current literature on the mechanisms involved in obesity-related perioperative morbidity. Methods. A literature search was performed using Medline, PubMed, Cochrane Library, and Internet searches. Keywords used include obesity, wound healing, adipose healing, and bariatric and surgical complications. Results. Substantial evidence exists demonstrating that obesity is associated with a number of postoperative complications. Specifically in relation to wound healing, explanations include inherent anatomic features of adipose tissue, vascular insufficiencies, cellular and composition modifications, oxidative stress, alterations in immune mediators, and nutritional deficiencies. Most recently, advances made in the field of gene array have allowed researchers to determine a few plausible alterations and deficiencies in obese individuals that contribute to their increased risk of morbidity and mortality, especially wound complications. Conclusion. While the literature discusses how obesity may negatively affect health on various of medical fronts, there is yet to be a comprehensive study detailing all the mechanisms involved in obesity-related morbidities in their entirety. Improved knowledge and understanding of obesity-induced physiological, cellular, molecular, and chemical changes will facilitate better assessments of surgical risks and outcomes and create efficient treatment protocols for improved patient care of the obese patient population.

show abstract

Section: Discussionmentioning

confidence: 99%

Obesity and Surgical Wound Healing: A Current Review

et al. 2014

View full text Add to dashboard Cite

show abstract

“… Bains et al (1966) found that young rats fed low iron (powdered milk) diet and subjected to repeated bleeding to produce chronic anemia had weaker wound tensile strength. However, later studies undertaken by Macon and Pories (1971) had contrary findings; iron-deficiency anemia (IDA) had no effect on wound breaking strength. This may reflect the methodological issues when using powdered milk to establish iron deficiency as Waterman et al (1952) showed that control and anemic rats fed powdered milk had slower wound contraction and reduced wound breaking strength, when compared with animals fed normal chow.…”

Section: Experimental Studies – Iron Anemia and Wound Healingmentioning

confidence: 99%

The role of iron in the skin and cutaneous wound healing

2014

View full text Add to dashboard Cite

In this review article we discuss current knowledge about iron in the skin and the cutaneous wound healing process. Iron plays a key role in both oxidative stress and photo-induced skin damage. The main causes of oxidative stress in the skin include reactive oxygen species (ROS) generated in the skin by ultraviolet (UVA) 320–400 nm portion of the UVA spectrum and biologically available iron. We also discuss the relationships between iron deficiency, anemia and cutaneous wound healing. Studies looking at this fall into two distinct groups. Early studies investigated the effect of anemia on wound healing using a variety of experimental methodology to establish anemia or iron deficiency and focused on wound-strength rather than effect on macroscopic healing or re-epithelialization. More recent animal studies have investigated novel treatments aimed at correcting the effects of systemic iron deficiency and localized iron overload. Iron overload is associated with local cutaneous iron deposition, which has numerous deleterious effects in chronic venous disease and hereditary hemochromatosis. Iron plays a key role in chronic ulceration and conditions such as rheumatoid arthritis (RA) and Lupus Erythematosus are associated with both anemia of chronic disease and dysregulation of local cutaneous iron hemostasis. Iron is a potential therapeutic target in the skin by application of topical iron chelators and novel pharmacological agents, and in delayed cutaneous wound healing by treatment of iron deficiency or underlying systemic inflammation.

show abstract

Wound healing

Brown¹,

Gibran²

2012

Handbook of Burns

View full text Add to dashboard Cite

The effect of iron deficiency anemia on wound healing

Cited by 3 publications

References 0 publications

Obesity and Surgical Wound Healing: A Current Review

Obesity and Surgical Wound Healing: A Current Review

The role of iron in the skin and cutaneous wound healing

Wound healing

Contact Info

Product

Resources

About