Abstract:To test the effect of insulin on renal perfusion and the participation of NO and PG as mediators of this response, renal blood flow (RBF) was measured in sheep (n = 8) implanted with ultrasonic flow probes around renal arteries and with a systemic arterial pressure (SAP, n = 4) telemetry device. Three protocols were performed: 1) RBF and SAP were recorded (0800 to 1800 h) in fed and fasted sheep, with the latter receiving intravenous (i.v.) infusions (0.5 mL/min) of insulin at 2 or 6 mU/(kg·min); 2) fasted she… Show more
“…A meta‐analysis supported their use in intensive care, with parenteral nutrition reducing mortality, but this study was not focused on kidney injury. Moreover, when examining in detail AA solutions, they contain several AA of potential interest during sepsis, which may exert a positive action on immunity or on signalling pathways altered in the time‐course of septic shock such as nitric oxide (NO) pathway . Glutamic acid, arginine, lysine, phenylalanine and tyrosine are for example present in Vintene and have been associated with interesting immunomodulatory effect during sepsis …”
Section: Discussionmentioning
confidence: 99%
“…Amino acids (AA) infusions have been associated in several species with an increase of RBF and glomerular filtration rate (GFR) without any systemic arterial pressure variation . These renal effects of AA could be used as a means of maintaining renal perfusion in sepsis condition associated with increased RVR.…”
“…A meta‐analysis supported their use in intensive care, with parenteral nutrition reducing mortality, but this study was not focused on kidney injury. Moreover, when examining in detail AA solutions, they contain several AA of potential interest during sepsis, which may exert a positive action on immunity or on signalling pathways altered in the time‐course of septic shock such as nitric oxide (NO) pathway . Glutamic acid, arginine, lysine, phenylalanine and tyrosine are for example present in Vintene and have been associated with interesting immunomodulatory effect during sepsis …”
Section: Discussionmentioning
confidence: 99%
“…Amino acids (AA) infusions have been associated in several species with an increase of RBF and glomerular filtration rate (GFR) without any systemic arterial pressure variation . These renal effects of AA could be used as a means of maintaining renal perfusion in sepsis condition associated with increased RVR.…”
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