2021
DOI: 10.5812/aapm.114318
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The Effect of Intrathecal Injection of Dextromethorphan on the Experimental Neuropathic Pain Model

Abstract: Background: Peripheral glucocorticoid receptors (GRs) are altered by peripheral nerve injury and may modulate the development of neuropathic pain. Two central pathogenic mechanisms underlying neuropathic pain are neuroinflammation and N-methyl-D-aspartate receptor (NMDAR)-dependent neural plasticity in the spinal cord. Objectives: This study examined the effect of the non-competitive NMDAR antagonist dextromethorphan on partial sciatic nerve ligation (PSL)-induced neuropathic pain and the spinal expression of … Show more

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Cited by 5 publications
(3 citation statements)
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References 43 publications
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“…The International Diabetes Federation estimates the global population of diabetes patients to reach 366 million by 2030. Of the complications, peripheral neuropathy is the most common and 20% -30% of patients with it develop diabetic peripheral neuropathic pain (DPNP) (38,39). Treatment can be challenging, and mirogabalin has been shown to provide benefit (40)(41)(42)(43).…”
Section: Diabetic Peripheral Neuropathic Painmentioning
confidence: 99%
“…The International Diabetes Federation estimates the global population of diabetes patients to reach 366 million by 2030. Of the complications, peripheral neuropathy is the most common and 20% -30% of patients with it develop diabetic peripheral neuropathic pain (DPNP) (38,39). Treatment can be challenging, and mirogabalin has been shown to provide benefit (40)(41)(42)(43).…”
Section: Diabetic Peripheral Neuropathic Painmentioning
confidence: 99%
“…However, it is also likely that additional pathways are involved. For example, recent studies have used nerve ligation animal models to show that dextromethorphan-mediated improvements in hyperalgesia may be related to the inhibition of glucocorticoid receptor-mediated neuroinflammation [ 21 ] and decreased expression of pTyr1336NR2B receptors [ 22 ].…”
Section: Introductionmentioning
confidence: 99%
“…Neuropathic pain originates from pathophysiological defects of the peripheral or central nervous system ( 1 , 2 ). Several animal models were introduced to investigate the pathological and physiological mechanisms of neuropathic pain.…”
Section: Introductionmentioning
confidence: 99%