The Effect of Intraoperative Systemic Lidocaine on Postoperative Persistent Pain Using Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials Criteria Assessment Following Breast Cancer Surgery: A Randomized, Double‐Blind, Placebo‐Controlled Trial

Abstract

Perioperative infusion of lidocaine has been reported to decrease the incidence of postsurgical pain at 3 and 6 months following mastectomy using dichotomous (yes/no) scoring. Although intravenous lidocaine reduced the reported incidence of pain at rest at 6 months, pain with activity, pain qualities, and the physical or emotional impact of the pain were unaffected. Future studies evaluating postsurgical persistent pain should adhere to the IMMPACT recommendations in order to more accurately describe the effect of an intervention on persistent pain.

Perioperative Pregabalin and Intraoperative Lidocaine Infusion to Reduce Persistent Neuropathic Pain After Breast Cancer Surgery: A Multicenter, Factorial, Randomized, Controlled Pilot Trial

“…Furthermore, in a recent randomized trial of 150 patients undergoing breast cancer surgery, lidocaine infusion did reduce pain in the area of surgery by 16% (P = .04) at the 6-month follow-up; however, this study did not find any difference in the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) criteria for persistent pain at 3 or 6 months. 26 Although these results add to an emerging body of literature in support of lidocaine infusions in breast cancer surgery, these studies are of small sample size or underpowered. A large, adequately powered trial is needed to definitively identify the beneficial effects of lidocaine infusions in a surgical breast cancer population.…”

Influence of volatile anesthesia versus total intravenous anesthesia on chronic postsurgical pain after cardiac surgery using the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials criteria: study protocol for a prospective randomized controlled trial

“…Few studies have used the IMMPACT recommendations [20]. IMMPACT is a consortium of researchers and practitioners in pain medicine whose mission is to develop consensus reviews and recommendations for improving the design, execution, and interpretation of clinical trials of treatments for pain [33]. The domains of pain recommended by IMMPACT show the diversified effect of anesthetics on pain at rest, pain during activity, the quality of pain, and the physical and emotional impact of pain.…”

Rationale and design of influence of volatile anesthesia versus total intravenous anesthesia on chronic postsurgical pain after cardiac surgery using Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials criteria assessment: study protocol for a prospective randomized controlled trial

“…On the other hand, prior studies focusing on CPSP in both cardiac and non-cardiac surgery assessed pain using a yes or no scoring system or the NRS valuing the intensity of pain, and seldom of them used the IMMPACT recommendations [20]. IMMPACT is a consortium of researchers and practitioners in pain medicine whose mission is to develop consensus reviews and recommendations for improving the design, execution, and interpretation of clinical trials of treatments for pain [33]. Assessing the domains of pain recommended by IMMPACT, it would show the diversified effect of anesthetics on pain at rest, pain with activity, pain qualities, or the physical or emotional impact of the pain.…”