The effect of intralipid on pregnancy outcomes in women with previous implantation failure in in vitro fertilization/intracytoplasmic sperm injection cycles: A systematic review and meta-analysis

Zhou, Ping; Wu, Hanglin; Lin, Xiaona; Wang, Shasha; Zhang, Song-ying

doi:10.1016/j.ejogrb.2020.06.057

Cited by 13 publications

(6 citation statements)

References 21 publications

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“…An intravenous emulsion of soybean oil, which contains both linoleic acid and the plant omega‐3 fatty acid alpha‐linolenic acid, has been used to attempt to improve IVF success rates in women with recurrent implantation failure. However, a recent systematic review concluded that, when studies with a high potential for bias were excluded, there is no significant benefit of this therapy (Zhou et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The Fatty Acid Composition of Human Follicular Fluid Is Altered by a 6‐Week Dietary Intervention That Includes Marine Omega‐3 Fatty Acids

Kermack

Wellstead

Fisk

et al. 2020

Lipids

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The fatty acid composition of human follicular fluid is important for oocyte development and for pregnancy following in vitro fertilization (IVF). This study investigated whether a dietary intervention that included an increase in marine omega-3 fatty acids, olive oil and vitamin D alters the fatty acid composition of human follicular fluid. The association of lifestyle factors with follicular fluid fatty acid composition was also investigated. Fiftyfive couples awaiting IVF were randomized to receive the 6-week treatment intervention of olive oil for cooking, an olive oil-based spread, and a daily supplement drink enriched with vitamin D and the marine omega-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) and 56 couples were randomized to receive placebo equivalents. Dietary questionnaires were completed, and samples of blood were taken before and after the intervention. Follicular fluid was collected at oocyte retrieval and the fatty acid profile assessed using gas chromatography. In the control group, individual fatty acids in red blood cells and follicular fluid were significantly correlated. Furthermore, a healthier diet was associated with a lower percentage of follicular fluid arachidonic acid. The follicular fluid of women in the treatment group contained significantly higher amounts of EPA and DHA compared to the control group, while the omega-6 fatty acids linoleic, γ-linolenic, dihomo-γ-linolenic, and arachidonic were lower. This is the first report of a dietary intervention altering the fatty acid composition of follicular fluid in humans. Further research is required to determine whether this intervention improves oocyte quality. Keywords DHA Á Diet Á EPA Á Follicular fluid Á IVF Á Omega-3 Á Vitamin D Lipids (2020).

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Section: Introductionmentioning

confidence: 99%

The Fatty Acid Composition of Human Follicular Fluid Is Altered by a 6‐Week Dietary Intervention That Includes Marine Omega‐3 Fatty Acids

Kermack

Wellstead

Fisk

et al. 2020

Lipids

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“…Results of a similar study demonstrated that abnormal NK cell function in patients who received intralipids was modulated to the normal range, after the first or second infusions [129]. According to a systematic review, a significant elevation in clinical pregnancy and live birth rate was observed after intravenous intralipid in RIF women [130]. There are several studies that indicated no beneficial effect of intralipid administration for RIF patients including the study of Shreeve et al [124] and Check et al [131].…”

Section: Intralipidsmentioning

confidence: 99%

Recent Advances in Immunotherapeutic Approaches for Recurrent Reproductive Failure

Abdolmohammadi-Vahid¹,

Aghebati‐Maleki²,

Ahmadian-Heris³

et al. 2023

IVF Technologies and Infertility - Current Practices and New Perspectives

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Human reproduction is an insufficient process, disturbed by various factors, such as immunologic aberrations of mother. Immunologic abnormalities, including cellular and humoral immunity imbalance, cause dysregulated immune responses against embryo, fetus, and associated components and lack of maternal immunotolerance, which compromise the maintenance of pregnancy. Therefore, evaluation of immunologic parameters, including cellular and humoral immunity assessment (T and B lymphocyte, T helper subtypes, NK cells, cytokines, and autoantibodies), especially in women with a history of pregnancy loss or implantation failure, would help clinicians to manage the disorder and prevent next unfavorable pregnancy outcomes. Moreover, several immunomodulatory approaches have been introduced to modulate the abnormal immunologic responses in patients who experience reproduction failure, especially those diagnosed with immunologic basis. Anticoagulants, corticosteroids, intravenous immunoglobulin, immunosuppressive medications used in inhibition of graft rejection, such as calcineurin inhibitors, recombinant cytokines, and cell therapy approaches, are among these modalities. Here, we discuss the proposed mechanisms of immunologic abnormalities involved in the etiopathogenesis of reproduction disorders, besides the suggested immunologic tests and immunotherapeutic approaches which may be helpful in management of these disorders.

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“…Between 2019 and 2020, we informed RPL patients with positive ATAb-activities and no established cause for their miscarriages, about the lack of established treatment approaches and a possibility of using off label IVIL during a consecutive pregnancy as an individual healing attempt 8,16,27 Also, we informed them of our interest in studying potential effects of IVIL infusions on their ATAb-activity. This Abbreviations: RPL, recurrent pregnancy loss; IVIL, intravenous intralipid infusion ; BMI, body mass index (Calculated as weight in kilograms divided by the square of height in meters); n, number.…”

Section: Off Label Treatment With Intravenous Intralipid Preparations...mentioning

confidence: 99%

“…1–2% of women suffer from recurrent pregnancy loss (RPL) and many of these miscarriages remain unexplained 1,2 . It has been postulated that immunologic disorders may be responsible for unexplained RPL and several studies point to close links between pregnancy loss and various forms of immunopathology 2–14 . In light of the increasing evidence of immunologic disorders associated with RPL, several immunomodulatory therapies have been evaluated in various groups of RPL patients 15–20 .…”

Section: Introductionmentioning

confidence: 99%

“…1,2 It has been postulated that immunologic disorders may be responsible for unexplained RPL and several studies point to close links between pregnancy loss and various forms of immunopathology. [2][3][4][5][6][7][8][9][10][11][12][13][14] In light of the increasing evidence of immunologic disorders associated with RPL, several immunomodulatory therapies have been evaluated in various groups of RPL patients. [15][16][17][18][19][20] Preliminary data suggest beneficial effects of intravenous intralipid infusions (IVIL) in women with a history of RPL 16,[21][22][23][24][25][26][27] and various immunomodulatory mechanisms have been claimed for IVIL to explain such results.…”

Section: Introductionmentioning

confidence: 99%

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Effects of intralipid infusions on anti‐trophoblast antibody (ATAb)‐activities in patients with recurrent pregnancy loss: An observational report

Rogenhofer

Mahner

Hasselbach

et al. 2021

American J Rep Immunol

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Problem: Some studies suggest intravenous intralipid infusions (IVIL) to be effective in the treatment of immune-mediated pregnancy failure. To this date it remains to be established, how IVIL might protect pregnancy and therefore a specific subgroup of RPL patients that might benefit from IVIL has not been defined. Anti-trophoblast antibodies (ATAb) have been associated with RPL and appear to mediate immune pathology. We have shown, that ATAb in vitro decrease HCG-and progesterone production pointing to a mechanism how ATAb interfere with normal pregnancies. We have measured ATAb-activities in patients undergoing off label IVIL-treatment. Method of study:Ten RPL-patients with positive ATAb, determined by using the choriocarcinoma cellline JEG-3 and flow cytometry as described before, and otherwise unexplained RPL, received off-label IVIL during pregnancy. Two ATAb-positive RPL patients preferred expectant management. In addition, ATAb-activity was studied in pregnancies of two healthy ATAb-negative volunteers without miscarriages. Results:In RPL patients receiving IVIL, relative ATAb-activity decreased from an average of 56.8±17.0% to 20.8±11.0% (P < .001). The two RPL-patients without IVIL, aborted at 6+3gw and 7+4gw and embryonic genetic testing revealed euploid karyotypes. During pregnancies of the two healthy ATAb-negative individuals, ATAbactivities remained negative (16±9.8%) without significant changes (P = .22). Nine of the 10 pregnancies receiving IVIL proceeded uneventful with healthy newborns ≥37gw. One patient receiving IVIL aborted at 7+6gw and embryonic genetic-testing revealed a trisomy 16. No specific side effects concerning IVIL were noted. Conclusions:Intralipid preparations during pregnancies of ATAb-positive RPL-patients significantly reduce ATAb-activities and this may indicate a therapeutic mechanism of IVIL.

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The effect of intralipid on pregnancy outcomes in women with previous implantation failure in in vitro fertilization/intracytoplasmic sperm injection cycles: A systematic review and meta-analysis

Cited by 13 publications

References 21 publications

The Fatty Acid Composition of Human Follicular Fluid Is Altered by a 6‐Week Dietary Intervention That Includes Marine Omega‐3 Fatty Acids

The Fatty Acid Composition of Human Follicular Fluid Is Altered by a 6‐Week Dietary Intervention That Includes Marine Omega‐3 Fatty Acids

Recent Advances in Immunotherapeutic Approaches for Recurrent Reproductive Failure

Effects of intralipid infusions on anti‐trophoblast antibody (ATAb)‐activities in patients with recurrent pregnancy loss: An observational report

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