The Effect of Interval Training on Oxidative Stress Indices Among Women in Preterm Labor Underwent Coronary Artery Bypass Graft

Abstract

Objectives: Oxidative stress indices are one of the factors that cause and exacerbate cardiovascular diseases in postpartum women, which can be changed with interval training. Therefore, the current study aimed at investigating the effect of interval training on oxidative stress indices among women in preterm labor undergoing the coronary artery bypass graft (CABG). Materials and Methods: This randomized clinical trial was conducted on 21 participants (the sample size was determined based on a similar study) from December 2018 to May 2019 at Shahid Madani hospital of Tabriz, Iran. After the random allocation of subjects to the training (n=11) and control (n=10) groups, demographic information was collected and their physical activity level was assessed using the Kaiser physical activity survey before and after the intervention. In addition, the levels of oxidative stress indices were measured 24 hours before and after the intervention using the blood sample. The participants completed an eight-week invention including 24 one-hour sessions according to the available protocol. Finally, data were analyzed by means of statistical tests such as the Shapiro-Wilk, Leven, and Student’s t-test at a significant level of <0.05. Results: The effect of the aerobic exercise program on body weight loss, as well as body mass index (BMI) and body fat percentage changes was significant in the training group (P=0.011, P=0.004, and P=0.001, respectively). Based on the results, the serum and urine levels of 8-hydroxy-2-deoxyguanosine reduced significantly after the completion of the intervention (P=0.002 and P=0.001, respectively) in the training group. Conclusions: In general, aerobic exercise after CABG decreased the fat percentile, BMI, and oxidative stress indices in the subjects. Thus, these trainings could reduce oxidative stress indices by increasing tissue metabolism and oxygen consumption.

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“…In an RCT on animal models performed by Apaijai, it was concluded that despite previous evidence of cardio protective effects of metformin, this drug has a very limited effect on HRV indices [20,[34][35][36]. Paolisso's study reflected that insulin treatment in a patient with insulin resistance cannot improve autonomic system function [21,[37][38][39]. In another study in the United States, it was found that the blood level of insulin was inversely proportional to HF and LF parameters, and in fact, people with high levels of insulin in their blood have a lower HRV.…”

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“…We think it is probably because first, we choose patients with the worse condition for dualchamber pacing than a single chamber. In addition, several potential settings should be taken into accounts such as dual-chamber pacing with short atrioventricular (AV) delay, ventricular pacing with a high base rate, and no programming of features that promote intrinsic ventricular rhythm [27][28][29]. Therefore, these results indicate that implanting a dual-chamber pacemaker needs a more precise basal setting to prevent high pacing dependency.…”

Developmental delay in preterm infants during the first twelve months after birth and its risk factors

“…[ 6 ] Research indicates that the possibility of neurodevelopmental and behavioral disorders is higher in premature-born children and adults. [ 7 8 ] For example, Moore et al .’s[ 9 ] study on the developmental status of 1,031 three-year-old children with less than 27 weeks of gestational age showed the incidence of moderate-to-severe developmental disorders in 25% of these children. A similar study in Sweden found that 18.8% of preterm infants had cognitive disorders at six years of age.…”