The effect of interference on temporal order memory for random and fixed sequences in nondemented older adults

Tolentino, Jerlyn C.; Pirogovsky, Eva; Luu, Trinh T.; Toner, Chelsea; Gilbert, Paul E.

doi:10.1101/lm.026062.112

Cited by 35 publications

(64 citation statements)

References 52 publications

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“…Many paradigms conflate temporal or sequential learning with spatial locations, making independent effects difficult to disentangle (e.g., Madsen and Kesner 1995). For example, Tolentino et al (2012) and Pirogovsky et al (2013) developed an elegant design modeled after a rodent 8-arm maze for use in humans to evaluate temporal sequence learning and reported that older adults were impaired relative to young adults on the sequence of locations. Likewise, Rajah et al (2010a,b) and Duarte et al (2008) utilized a paradigm that presented images in varying spatial locations and later queried which of two items came earlier than the other or in which spatial location.…”

Section: Discussionmentioning

confidence: 99%

“…Previous research has shown that older adults are impaired at remembering sequences of verbal stimuli (Fabiani and Friedman 1997;Dennis et al 2003;Bastin and Van der Linden 2005;Giovanello and Schacter 2012) and spatial locations on a screen (Tolentino et al 2012;Pirogovsky et al 2013). In addition, lesion studies in rodents Fortin et al 2002;Kesner et al 2002;Hannesson et al 2004;DeVito and Eichenbaum 2011) and functional neuroimaging studies in humans (Ekstrom and Bookheimer 2007;Tubridy and Davachi 2011) indicate this capacity depends on the hippocampus and prefrontal cortex, structures known to be specifically disrupted in normal aging, both in rodents and humans (Barnes 1994;Erickson and Barnes 2003;Dennis et al 2007;Yassa and Stark 2011).…”

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confidence: 99%

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Memory for sequences of events impaired in typical aging

et al. 2015

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Typical aging is associated with diminished episodic memory performance. To improve our understanding of the fundamental mechanisms underlying this age-related memory deficit, we previously developed an integrated, cross-species approach to link converging evidence from human and animal research. This novel approach focuses on the ability to remember sequences of events, an important feature of episodic memory. Unlike existing paradigms, this task is nonspatial, nonverbal, and can be used to isolate different cognitive processes that may be differentially affected in aging. Here, we used this task to make a comprehensive comparison of sequence memory performance between younger (18-22 yr) and older adults (62 -86 yr). Specifically, participants viewed repeated sequences of six colored, fractal images and indicated whether each item was presented "in sequence" or "out of sequence." Several out of sequence probe trials were used to provide a detailed assessment of sequence memory, including: (i) repeating an item from earlier in the sequence ("Repeats"; e.g., ABADEF), (ii) skipping ahead in the sequence ("Skips"; e.g., ABDDEF), and (iii) inserting an item from a different sequence into the same ordinal position ("Ordinal Transfers"; e.g., AB3DEF). We found that older adults performed as well as younger controls when tested on well-known and predictable sequences, but were severely impaired when tested using novel sequences. Importantly, overall sequence memory performance in older adults steadily declined with age, a decline not detected with other measures (RAVLT or BPS-O). We further characterized this deficit by showing that performance of older adults was severely impaired on specific probe trials that required detailed knowledge of the sequence (Skips and Ordinal Transfers), and was associated with a shift in their underlying mnemonic representation of the sequences. Collectively, these findings provide unambiguous evidence that the capacity to remember sequences of events is fundamentally affected by typical aging.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Memory for sequences of events impaired in typical aging

et al. 2015

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“…The increase in temporal interference impairs the rat's ability to remember the order of specific events. Tolentino et al (2012) used an analogous task to that used for rats (Gilbert et al, 2001) to test young compared to non-demented older participants in a spatial temporal pattern separation task and report temporal pattern separation problems for the older participants. In another spatial location task, patients with a hypoxic condition and hippocampal damage were impaired in displaying a temporal pattern separation function (Hopkins et al, 1995a).…”

Section: Pattern Separation --Temporal Attributementioning

confidence: 99%

Neurobiological foundations of an attribute model of memory

Kesner¹

2013

CCBR

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Memory is a complex phenomenon due to a large number of potential interactions that are associated with the organization of memory at the psychological and neural system level. In this review article a tripartite, multiple attribute, multiple process memory model with different forms of memory and its neurobiological underpinnings is represented in terms of the nature, structure or content of information representation as a set of different attributes including language, time, place, response, reward value (affect) and visual object as an example of sensory-perception. For each attribute, information is processed in the event-based, knowledge-based, and rule-based memory systems through multiple operations that involve multiple neural underpinnings. Of the many processes associated with the event-based memory system, the emphasis will be placed on short-term or working memory and pattern separation. Of the many processes associated with the knowledgebased memory system, the emphasis will be placed on perceptual processes. Of the many processes associated with the rule-based memory system the emphasis will be on short-term or working memory and paired associate learning. For all three systems data will be presented to demonstrate differential neuroanatomical mediation and where available parallel results will be presented in rodents, monkeys and humans.

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“…Pattern separation has been shown to be less efficient in older adults on tasks involving spatial locations (Stark et al 2010;Holden et al 2012), visual objects (Toner et al 2009;Yassa et al 2011a;Stark et al 2013), and temporal order of items in a sequence (Tolentino et al 2012). Neuroimaging studies indicate that these age-related changes in pattern separation may be associated with functional and structural changes in the hippocampal network in older adults (Yassa et al 2011a,b).…”

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confidence: 99%

Visual object pattern separation varies in older adults

et al. 2013

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Young and nondemented older adults completed a visual object continuous recognition memory task in which some stimuli (lures) were similar but not identical to previously presented objects. The lures were hypothesized to result in increased interference and increased pattern separation demand. To examine variability in object pattern separation deficits, older adults were divided into impaired and unimpaired groups based on performance on a standardized serial list-learning task. Impaired older adults showed intact recognition memory, but were impaired relative to young and unimpaired older adults when identifying similar lure stimuli, demonstrating that object pattern separation varies in older adults.

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The effect of interference on temporal order memory for random and fixed sequences in nondemented older adults

Cited by 35 publications

References 52 publications

Memory for sequences of events impaired in typical aging

Memory for sequences of events impaired in typical aging

Neurobiological foundations of an attribute model of memory

Visual object pattern separation varies in older adults

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