The effect of intense exercise on the cell-mediated immune response of horses

Kurcz, E; Lawrence, Lincy; Kelley, Keith W.; Miller, Paul A.

doi:10.1016/s0737-0806(88)80015-7

Cited by 27 publications

(18 citation statements)

References 2 publications

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“…Robson et al (2003) encontraram neutrofilia e linfopenia evidentes uma hora e um dia após enduro de 80km, retornando à normalidade somente três dias após, como ocorreu no presente estudo. Alguns autores (Kurcz et al, 1998;Lunn et al, 2001), que trabalharam com cavalos em esteira rolante de alta velocidade, encontraram supressão da resposta proliferativa de linfócitos, porém Cywińska et al (2012) encontraram diminuição dessa resposta somente em cavalos de longa distância (160km) e não nos cavalos de regularidade.…”

Section: Resultsunclassified

Resposta hematológica de cavalos de enduro, que correram diferentes distâncias, no período pós-prova

Siqueira

Fernandes

2017

Arq. Bras. Med. Vet. Zootec.

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Section: Resultsunclassified

Resposta hematológica de cavalos de enduro, que correram diferentes distâncias, no período pós-prova

Siqueira

Fernandes

2017

Arq. Bras. Med. Vet. Zootec.

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“…'~.~~,~' Hormonal responses in exercising horses are generally consistent with those seen in other species,24,80,X1 Particular attention has been given to cortisol concentrations, which are increased both in the circulation and bronchoalveolar lavage fluid after acute high-intensity exer-Likewise, rises in plasma cortisol concentrations similar to those seen after brief, high-intensity exercise have been documented at completion and 30 minutes after an 80-km endurance ride." In addition, significant increases in plasma concentrations of both epinephrine and norepi-cise.21 .24, 54,55,73,80 nephrine have been demonstrated after exercise in Thoroughbreds; these increases are directly related to both exercise intensity and duration.R2 Epinephrine and norepinephrine concentrations were also increased immediately after endurance exercise, although not to the extent seen after highintensity exercise. "…”

Section: Neuroendocrine Hormonesmentioning

confidence: 98%

Exercise and Immunity: A Review with Emphasis on the Horse

Hines

Schott

Bayly

et al. 1996

Veterinary Internal Medicne

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Exercise has been recognized as a stress, which can significantly alter the host's immune response and, therefore, its susceptibility to disease. Whereas research in this area has previously focused primarily on human subjects and laboratory animals, it has more recently extended to domestic animals, especially the equine athlete. Despite several studies, defining the relationship among exercise, the immune response, and disease has proven difficult due to a number of factors, including the complexity of the immune system and the variable nature of exercise itself. It now appears that exercise has dual effects on the immune system. Supn association between exercise and disease susceptibil-A ity was recognized as early as 1918, when it was reported that pneumonia was more common in human athletes than in sedentary individuals, and that strenuous exercise increased the risk of upper respiratory tract infections progressing to pneumonia.' Since that time, several studies have investigated the relationship among exercise, the immune response, and disease, leading to recognition that the stress of exercise has profound but variable effects on the immune Although comparatively little is known about the specific effects of exercise on immunity in domestic animals, the strenuous exercise that horses and other performance animals routinely engage in makes this subject of importance in veterinary medicine. In this article, we review the literature examining the relationship between exercise and immunity, and its clinical relevance. Effects of Exercise on the Immune SystemConsiderable research has investigated the effects of exercise on the immune system, and while it has been established that virtually every aspect of both the nonspecific and specific immune systems can be affected by exercise, the definitive results of these studies often appear conflicting.*-"' Several factors contribute to the variability among studies, including the complexity of the immune system and differences in experimental design. Function of the immune system depends on a number of cell types, receptor systems, soluble mediators, and their interactions. The effects of exercise on isolated components of the immune system may not reflect a change in the overall immune status. Likewise, because variations in the intensity, duration, or specific type of activity can have significant effects on the response of the immune system, the nature of the exercise being studied

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“…Exercise is considered a physical stressor and has been shown to have profound effects on the immune system of man (Nieman 1994a), pigs (Waern and Fossum 1993), cattle (Blecha and Minocha 1983) and rats (Baldwin et al 1997). Previous studies in our and other laboratories have shown dramatic effects of exercise on the immune system of the horse (Kurcz et al 1988;Lagried et al 1988;Wong et al 1992;Keadle et al 1993;Horohov et al 1999). However, the in vivo significance of these alterations in immune function measured in vitro r e m a i n s uncertain.…”

Section: Introductionmentioning

confidence: 99%

Exercise alters the immune response to equine influenza virus and increases susceptibility to infection

Folsom

Littlefield-Chabaud

French

et al. 2001

Equine Veterinary Journal

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Summary Equine influenza virus remains a major health concern for the equine industry in spite of ongoing vaccination programmes. Previous work has shown that the immune system of horses can be affected by strenuous exercise. The possible adverse consequence of exercise‐induced alterations in lymphocyte responses measured in vitro was unknown. Here we demonstrate that subjecting vaccinated ponies to a 5 day strenuous exercise programme results in a significant suppression of their T cell‐mediated immune response to equine influenza virus as measured by decreased lymphoproliferation and gamma interferon production measured in vitro. These same ponies also demonstrated increased susceptibility to influenza disease following a challenge exposure to the same strain of virus. Rested ponies that had received the same vaccine and challenge were completely protected from disease. Our results demonstrate that exercise‐induced suppression of the equine immune response to influenza virus can be associated with an increased susceptibility to disease.

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The effect of intense exercise on the cell-mediated immune response of horses

Cited by 27 publications

References 2 publications

Resposta hematológica de cavalos de enduro, que correram diferentes distâncias, no período pós-prova

Resposta hematológica de cavalos de enduro, que correram diferentes distâncias, no período pós-prova

Exercise and Immunity: A Review with Emphasis on the Horse

Exercise alters the immune response to equine influenza virus and increases susceptibility to infection

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