2014
DOI: 10.1089/met.2014.0071
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The Effect of Insulin Resistance on Breast Cancer Risk in Latinas of Mexican Origin

Abstract: The findings suggest that IR had no effect on breast cancer risk; however HbA1c increased the risk in Latinas of Mexican origin who had not been diagnosed previously with prediabetes or diabetes and had no direct family history of breast cancer. Prospective studies are required to establish the impact of IR over time.

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Cited by 5 publications
(5 citation statements)
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“…93 A case-control study found that insulin resistance did not have an effect on breast cancer risk; however, increased HbA1C levels were associated with increased breast cancer risk. 96 Collectively, these findings demonstrated the relevance of targeting insulin signaling and function as markers of breast cancer risk.…”
Section: Obesitymentioning
confidence: 88%
“…93 A case-control study found that insulin resistance did not have an effect on breast cancer risk; however, increased HbA1C levels were associated with increased breast cancer risk. 96 Collectively, these findings demonstrated the relevance of targeting insulin signaling and function as markers of breast cancer risk.…”
Section: Obesitymentioning
confidence: 88%
“…High serum insulin levels can drive breast cancer incidence, and this explains the association between obesity and breast cancer (8). However, Cordero-Franco et al (9) reported an absence of a link between IR and breast cancer incidence, which is similar to the results presented by Mink et al (10) and Muti et al (11) who found no relationship between increased breast cancer risk and insulin.…”
Section: Introductionmentioning
confidence: 52%
“…After independently selecting titles and abstracts, the two reviewers excluded 5,731 articles and 355 articles were evaluated for eligibility. Ultimately, 17 studies were included (9,11,(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). We found a total 40 articles from references of relevant studies and showed them in the flow chart, but they were all included in the retrieved articles (Figure 1).…”
Section: Literature Searchmentioning
confidence: 99%
“…Conversely, limited information on the lesions' nature (i. e., benign vs. malignant) and basic histological features of the breast masses characterized (i. e., in situ vs. invasive breast cancer and lobular vs. ductal carcinoma) were reported by Abbasi and co-authors and a quick referral to the specific setting, i. e., adjuvant setting, and therapeutic management for some of the patients included appear in the latest paragraph of the results in the manuscript from Gonullu and colleagues (Lawlor et al, 2004;Sieri et al, 2012). Again, no hints on standard disease-related clinical and molecular features were reported for cancer cases in the work from Cordero-Franco et al (2014).…”
Section: Discussionmentioning
confidence: 97%
“…Data from this study do not provide support to the association between HOMA-IR and breast cancer risk. However, when testing the association with glycated hemoglobin (HbA1c), a parameter reflecting average pre-and postprandial glucose levels over the past 6-8 weeks, the authors observed an increased breast cancer risk in preand post-menopausal women with HbA1c !5.7% (Cordero-Franco et al, 2014). The critical appraisal of the literature cited above provides several hints for discussion.…”
Section: Discussionmentioning
confidence: 99%