The Effect of Insulin Resistance on Breast Cancer Risk in Latinas of Mexican Origin

Cordero-Franco, Hid Felizardo; Salinas-Martı́nez, Ana Marı́a; Abundis, Alberto Rangel; Espinosa-Flores, Eva María; Vázquez-Lara, Julia; Guerrero‐Romero, Fernando

doi:10.1089/met.2014.0071

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…93 A case-control study found that insulin resistance did not have an effect on breast cancer risk; however, increased HbA1C levels were associated with increased breast cancer risk. 96 Collectively, these findings demonstrated the relevance of targeting insulin signaling and function as markers of breast cancer risk.…”

Section: Obesitymentioning

confidence: 88%

Role of n-3 Polyunsaturated Fatty Acids and Exercise in Breast Cancer Prevention: Identifying Common Targets

Abdelmagid

MacKinnon

Janssen

et al. 2016

Nutr Metab Insights

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Diet and exercise are recognized as important lifestyle factors that significantly influence breast cancer risk. In particular, dietary n-3 polyunsaturated fatty acids (PUFAs) have been shown to play an important role in breast cancer prevention. Growing evidence also demonstrates a role for exercise in cancer and chronic disease prevention. However, the potential synergistic effect of n-3 PUFA intake and exercise is yet to be determined. This review explores targets for breast cancer prevention that are common between n-3 PUFA intake and exercise and that may be important study outcomes for future research investigating the combined effect of n-3 PUFA intake and exercise. These lines of evidence highlight potential new avenues for research and strategies for breast cancer prevention.

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Section: Obesitymentioning

confidence: 88%

Role of n-3 Polyunsaturated Fatty Acids and Exercise in Breast Cancer Prevention: Identifying Common Targets

Abdelmagid

MacKinnon

Janssen

et al. 2016

Nutr Metab Insights

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“…High serum insulin levels can drive breast cancer incidence, and this explains the association between obesity and breast cancer (8). However, Cordero-Franco et al (9) reported an absence of a link between IR and breast cancer incidence, which is similar to the results presented by Mink et al (10) and Muti et al (11) who found no relationship between increased breast cancer risk and insulin.…”

Section: Introductionmentioning

confidence: 52%

“…After independently selecting titles and abstracts, the two reviewers excluded 5,731 articles and 355 articles were evaluated for eligibility. Ultimately, 17 studies were included (9,11,(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). We found a total 40 articles from references of relevant studies and showed them in the flow chart, but they were all included in the retrieved articles (Figure 1).…”

Section: Literature Searchmentioning

confidence: 99%

Association Between Serum Insulin and C-Peptide Levels and Breast Cancer: An Updated Systematic Review and Meta-Analysis

Song

Yuan

et al. 2020

Front. Oncol.

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Background: Several studies have reported that hyperinsulinemia plays a part in the etiology of breast cancer. However, no consensus has been reached. Therefore, we conducted a meta-analysis to explore the role of insulin and C-peptide in breast cancer.Methods: A systematic search in PubMed, Embase, and The Cochrane Library was conducted up to September, 2020. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were used to measure effect sizes. Publication bias was assessed using the Egger test. Stability of these results was evaluated using sensitivity analyses.Results: Fourteen articles including 27,084 cases and five articles including 2,513 cases were extracted for serum insulin levels and C-peptide levels. We found that C-peptide levels were positively associated with breast cancer with overall SMD = 0.37 (95% CI = 0.09-0.65, I 2 = 89.1%). Subgroup analysis by control source illustrated a positive relationship between breast cancer and C-peptide levels in population-based control. Subgroup analysis by C-peptide level indicated a positive correlation between breast cancer and C-peptide levels no matter C-peptide levels in case group is ≤3 ng/ml or >3 ng/ml. Subgroup analysis by age showed that C-peptide level positively correlated to breast cancer in women between the ages of 50 and 60. However, we did not identify any relationship between breast cancer and insulin levels (SMD = 0.22, 95% CI = −0.06-0.50, I 2 = 97.3%). Conclusion:This meta-analysis demonstrated that C-peptide levels were positively related to breast cancer in women, and no relationship between insulin levels and breast cancer was found.

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“…Conversely, limited information on the lesions' nature (i. e., benign vs. malignant) and basic histological features of the breast masses characterized (i. e., in situ vs. invasive breast cancer and lobular vs. ductal carcinoma) were reported by Abbasi and co-authors and a quick referral to the specific setting, i. e., adjuvant setting, and therapeutic management for some of the patients included appear in the latest paragraph of the results in the manuscript from Gonullu and colleagues (Lawlor et al, 2004;Sieri et al, 2012). Again, no hints on standard disease-related clinical and molecular features were reported for cancer cases in the work from Cordero-Franco et al (2014).…”

Section: Discussionmentioning

confidence: 97%

“…Data from this study do not provide support to the association between HOMA-IR and breast cancer risk. However, when testing the association with glycated hemoglobin (HbA1c), a parameter reflecting average pre-and postprandial glucose levels over the past 6-8 weeks, the authors observed an increased breast cancer risk in preand post-menopausal women with HbA1c !5.7% (Cordero-Franco et al, 2014). The critical appraisal of the literature cited above provides several hints for discussion.…”

Section: Discussionmentioning

confidence: 99%

Anthropometric, Metabolic and Molecular Determinants of Human Epidermal Growth Factor Receptor 2 Expression in Luminal B Breast Cancer

Vici¹,

Crispo

Giordano

et al. 2015

J. Cell. Physiol.

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Genomic and trascriptomic profiling has recently contributed details to the characterization of luminal B breast cancer. We explored the contribution of anthropometric, metabolic, and molecular determinants to the multifaceted heterogeneity of this breast cancer subtype, with a specific focus on the association between body mass index (BMI), pre-treatment fasting glucose, hormone receptors, and expression of human epidermal growth factor receptor 2 (HER2). Extensively annotated specimens were obtained from 154 women with luminal B breast cancer diagnosed at two Italian comprehensive cancer centres. Participants' characteristics were descriptively analyzed overall and by HER2 status (positive vs. negative). BMI (<25 vs ≥25), pre-treatment fasting glucose (

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The Effect of Insulin Resistance on Breast Cancer Risk in Latinas of Mexican Origin

Cited by 5 publications

References 27 publications

Role of n-3 Polyunsaturated Fatty Acids and Exercise in Breast Cancer Prevention: Identifying Common Targets

Role of n-3 Polyunsaturated Fatty Acids and Exercise in Breast Cancer Prevention: Identifying Common Targets

Association Between Serum Insulin and C-Peptide Levels and Breast Cancer: An Updated Systematic Review and Meta-Analysis

Anthropometric, Metabolic and Molecular Determinants of Human Epidermal Growth Factor Receptor 2 Expression in Luminal B Breast Cancer

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