The effect of insulin and atropine on bile volume and composition

MacDonald, A.C.; MacKay, C; MacAllister, Raymond J.

doi:10.1016/0022-4804(77)90014-2

Cited by 4 publications

(3 citation statements)

References 13 publications

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“…The direct choleretic response of vagal stimulation is abolished following vagotomy (McKelvey et al, 1973) and also by vagal blockade by atropine (MacDonald et al, 1977). In addition, in the dog bile flow may be reduced following truncal vagotomy and cholate secretion is also apparently reduced (Fletcher and Clark, 1969).…”

Section: Discussionmentioning

confidence: 84%

“…Indirect vagal stimulation using insulin hypoglycaemia is also reported to have a direct choleretic action mediated predominantly by the vagus (Baldwin et al, 1966;Lundy et al, 1973;MacDonald et al, 1977), although others report that insulin action is not vagally mediated (Geist and Jones, 1971;Gourlay and Jones, 1972). Discrepancies in observations may reflect differences in experi mental protocols and species peculiarities.…”

Section: Discussionmentioning

confidence: 99%

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The Influence of Vagotomy on Bile Kinetics in the Rhesus Monkey

McMaster¹,

Medd²,

McLeish³

1979

Eur Surg Res

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An increased incidence of gallstones has been reported following truncal vagotomy and gastric drainage but never conclusively proven. In the Rhesus monkey, bile composition and flow is similar to man. A model of biliary drainage was established which permits continuous monitoring of bile kinetics. Following truncal vagotomy and pyloroplasty, a significant fall in bile acid concentration was observed, accompanied by a rise in cholesterol concentration. This resulted in an overall rise in cholesterol saturation. Similar changes in hepatic bile composition were, however, also seen following pyloroplasty alone, and suggests that the vagotomy itself may not be the important factor in producing bile changes.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

The Influence of Vagotomy on Bile Kinetics in the Rhesus Monkey

McMaster¹,

Medd²,

McLeish³

1979

Eur Surg Res

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“…Ductular secretion seems to be regulated principally by secretin (Wheeler et al 1968). Only a few reports have been published dealingwith the effects of anticholinergic drugs on bile flow (Preisig et al 1962;McDonald et al 1977),…”

Section: Discussionmentioning

confidence: 99%

The effect of atropine on canine bile flow and biliary excretion of ioglycamate

1980

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The effect of atropine on the bile flow and biliary excretion of ioglycamate, a biliary contrast medium, was studied on four anesthetized mongrel dogs equipped with a Thomas cannula through which the common bile duct was cannulated. With an infusion rate of 2 microgram/kg/min atropine sulphate decreased bile flow significantly. At the same time, the biliary concentration of ioglycamate was significantly increased. The biliary output of ioglycamate did not change during atropine infusion. The present study suggests that in this experimental model atropine decreases the bile flow but does not affect the excretion of ioglycamate.

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The Effect of Insulin and Hydrocortisone on the Isolated Rat Liver

Groufsky

Holland

Lee

1978

Australian and New Zealand Journal of Surgery

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Isolated rat livers were perfused at 35 degrees C with bovine serum albumin (40 g/l) in Krebs Ringer bicarbonate buffer, or with the same solution containing insulin (0.22 x 10(-6) mol/l), hydrocortisone (0.068 x 10(-3) mol/l), or both hormones together. Observations on the synthesis of bile and on perfusate levels of potassium, aspartate aminotransferase, urea and glucose showed that the presence of insulin and/or hydrocortisone had no beneficial effect on the perfused rat liver in vitro. There is little justification of the isolated liver.

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The effect of insulin and atropine on bile volume and composition

Cited by 4 publications

References 13 publications

The Influence of Vagotomy on Bile Kinetics in the Rhesus Monkey

The Influence of Vagotomy on Bile Kinetics in the Rhesus Monkey

The effect of atropine on canine bile flow and biliary excretion of ioglycamate

The Effect of Insulin and Hydrocortisone on the Isolated Rat Liver

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