The Effect of Injected Thiouracil on Body Weight and Hatchability of the Chick Embryo

Sinha, Mayank; Ringer, Robert K.; Coleman, T. H.; Zindel, H. C.

doi:10.3382/ps.0381405

Cited by 7 publications

(4 citation statements)

References 7 publications

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“…Grossowicz (1946) injected thiourea into chick embryo yolk sacs between the 7th and 17th days of incubation and observed a delay of 10 days in pipping. Injections of eidier thiourea or thiouracil at various stages of incubation have corroborated these initial observations (Adams and Bull;1949;Adams and Buss, 1952;Romijn et al, 1952;Romanoff and Laufer, 1956;Sinha et al, 1959;Balaban and Hill, 1971). Balaban and Hill (1971) observed that thyroid function blocked by thiourea caused coincidental reduced loss of yolk sac material and delayed puncture of the chorioallantoic membrane, whereas exogenous injections of thyroxine (T 4 ) reinitiated both processes and led to successful hatching.…”

Section: Introductionsupporting

confidence: 67%

“…The first was a "pipping stimulus", thought to be gaseous in nature, whereas the second, "a hatching stimulus", was considered to be hormonal. Previous data in chick embryos would suggest thyroid hormones are likely candidates for the hatching stimulus in that species (Grossowicz, 1946;Sinha et al, 1959;Balaban and Hill, 1971), but no data were found concerning plasma T3 or T4 concentrations in pipping and hatching poult embryos.…”

Section: Discussionmentioning

confidence: 82%

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Physiology of Turkey Embryos During Pipping and Hatching. III. Thyroid Function ,

1982

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Metabolic rates, as measured by oxygen consumption and air cell temperatures, increased significantly (P<.01) as pipping and hatching occurred in turkey embryos. Increased metabolic rates were accompanied by significant (P<.01) increases in both circulating plasma thyroxine (T 4 ) and triiodothyronine (T 3 ) concentrations. Both T 3 and T 4 plasma concentrations declined significandy (P<.01) as the poult emerged from the shell, but the T 3 /T 4 ratio increased.(

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Section: Introductionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 82%

Physiology of Turkey Embryos During Pipping and Hatching. III. Thyroid Function ,

1982

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“…Manipulation of egg TH levels influences avian hatching time. Injection of antithyroid drugs in the yolk sac of chick embryos retards hatching, and T 4 fully neutralizes these effects (Grossowicz, 1946;Adams and Bull, 1949;Romanoff and Laufer, 1956;Sinha et al, 1959;Balaban and Hill, 1971;Haba et al, 2011). In turkey, T 4 or T 3 injected to fertile eggs at Day 0 of incubation depresses hatchability, while improving it when administered at Day 25 of incubation out of a 28-day incubation period (Christensen, 1985).…”

Section: Involvement Of Thyroid Hormonesmentioning

confidence: 99%

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

2021

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Post-embryonic acute developmental processes mainly allow the transition from one life stage in a specific ecological niche to the next life stage in a different ecological niche. Metamorphosis, an emblematic type of these post-embryonic developmental processes, has occurred repeatedly and independently in various phylogenetic groups throughout metazoan evolution, such as in cnidarian, insects, molluscs, tunicates, or vertebrates. This review will focus on metamorphoses and developmental transitions in vertebrates, including typical larval metamorphosis in anuran amphibians, larval and secondary metamorphoses in teleost fishes, egg hatching in sauropsids and birth in mammals. Two neuroendocrine axes, the hypothalamic-pituitary-thyroid and the hypothalamic-pituitary-adrenal/interrenal axes, are central players in the regulation of these life transitions. The review will address the molecular and functional evolution of these axes and their interactions. Mechanisms of integration of internal and environmental cues, and activation of these neuroendocrine axes represent key questions in an “eco-evo-devo” perspective of metamorphosis. The roles played by developmental transitions in the innovation, adaptation, and plasticity of life cycles throughout vertebrates will be discussed. In the current context of global climate change and habitat destruction, the review will also address the impact of environmental factors, such as global warming and endocrine disruptors on hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal/interrenal axes, and regulation of developmental transitions.

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“…Although thionamides can cross the mammalian placenta and exert an inhibiting effect on fetal thyroid, there is no experimental evidence in animals (28)(29)(30)(31)(32)(33)(34)(35)(36)(37) or in man (37,38) …”

mentioning

confidence: 99%

Phenylthiocarbamide Non-Tasting Among Congenital Athyrotic Cretins: Further Studies in an Attempt to Explain the Increased Incidence*

Shepard¹

1961

J. Clin. Invest.

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The Effect of Injected Thiouracil on Body Weight and Hatchability of the Chick Embryo

Cited by 7 publications

References 7 publications

Physiology of Turkey Embryos During Pipping and Hatching. III. Thyroid Function ,

Physiology of Turkey Embryos During Pipping and Hatching. III. Thyroid Function ,

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

Phenylthiocarbamide Non-Tasting Among Congenital Athyrotic Cretins: Further Studies in an Attempt to Explain the Increased Incidence*

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