The effect of initial precipitates on the induction period of l-ornithine-l-aspartate during semi-batch drowning out crystallization

Kim, Ye-Hoon; Hyung, Woochan; Haam, Seungjoo; Shul, Yong Gun; Koo, Kee-Kahb

doi:10.1016/j.jcrysgro.2005.10.127

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Antisolvent crystallization − is widely utilized as an isolation and purification method in industries nowadays because of its low cost and high efficiency. In a crystallization system that utilizes a binary solvent, oiling-out − or liquid–liquid phase separation, which refers to the appearance of a second liquid, frequently occurs during crystallization development at the plant scale.…”

Section: Introductionmentioning

confidence: 99%

Process Design for Antisolvent Crystallization of Erythromycin Ethylsuccinate in Oiling-out System

Yin

Zhang

et al. 2016

Ind. Eng. Chem. Res.

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The crystallization process of erythromycin ethylsuccinate in a tetrahydrofuranwater system was investigated. Results show that oiling out occurs under several conditions; hence, a phase diagram with a liquid-liquid equilibrium area was established experimentally. For improved understanding of oiling-out crystallization, a series of in-situ tools, including FBRM, ATR-FTIR, and PVM, were applied to monitor the oiling-out phenomenon and the subsequent nucleation of erythromycin ethylsuccinate. SEM images were employed to analyze the influence of oiling out on the properties of the final crystals. The nucleation mechanism of erythromycin ethylsuccinate differs significantly depending on the location of the line of operation.The combination of cooling method and anti-solvent crystallization can be achieved with fundamental data of the phase diagram to suppress the oiling out phenomenon and obtain crystal products with high quality. The ternary phase diagram is of great importance in the process design of anti-solvent crystallization for an oiling-out system.

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Section: Introductionmentioning

confidence: 99%

Process Design for Antisolvent Crystallization of Erythromycin Ethylsuccinate in Oiling-out System

Yin

Zhang

et al. 2016

Ind. Eng. Chem. Res.

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“…Galvão et al used methanol as an antisolvent to determine the solubility of NaCl, KCl, and NH 4 Cl in the methanol–water system. A variety of other products can be obtained by using methanol as an antisolvent in crystallization, e.g., l -histidine, , l -ornithine- l -aspartate, cephradine, and glycine . In order to solve the problems existing in the traditional MKP production process, methanol was selected as an antisolvent to replace the traditional crystallization process in this paper.…”

Section: Introductionmentioning

confidence: 99%

Thermodynamic Modeling the Solid–Liquid Phase Equilibrium of a Water–Methanol–Potassium Dihydrogen Phosphate Ternary System with a Mixed-Solvent Electrolyte (MSE) Model

et al. 2023

Ind. Eng. Chem. Res.

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The solubility measurement of potassium dihydrogen phosphate (MKP) in a water−methanol system is of great significance for the salting-out crystallization of MKP. The solubility of MKP in the H 2 O−CH 3 OH solution was determined by the static equilibrium method in the range of 283.15−343.15 K, and the molar fraction of CH 3 OH varied from 0.0588 to 0.6923. The mixedsolvent electrolyte model (MSE) was used to regress the experimental results, and new parameters were obtained. Based on it, the thermodynamic model of the H 2 O−CH 3 OH−MKP system was established, which is in good agreement with the experimental results, with a relative average absolute deviation of 6.46%. Then, the change in the ion concentration and the activity coefficients in the system were predicted by the thermodynamic model. Finally, the Pixact Crystallization Monitoring (PCM) system and a scanning electron microscope (SEM) were used to observe the crystallization process and the morphology of MKP in the H 2 O− CH 3 OH system, respectively.

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“…There is a modest body of literature concerning the nucleation mechanism of small molecules such as inorganic salts, organic salts, − and proteins . The induction period may be determined either by visual observation, measurement of turbidity, or measurement of any concentration-dependent property which varies sufficiently in the course of the crystallization process such as conductivity, ,,− intensity of transmitted or scattered light, ,− pH, heat released, , and activity of precipitated ions . However, to the best of our knowledge, there is no study on the induction period of asiaticoside or madecassoside and their nucleation or crystal growth mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Solubility and Induction Period Study of Asiaticoside and Madecassoside in a Methanol + Water Mixture

Zheng

Lü

2012

J. Chem. Eng. Data

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The solubilities of madecassoside in a mixture of methanol + water were determined in the temperature range from (298.15 to 328.15) K by a static analytical method. A "W"-type curve was found for the solubility of madecassoside in the mixture of methanol + water. The induction periods of asiaticoside and madecassoside in a mixture of methanol + water were determined at 298.15 K by a laser scattering method. The results show that the solubilities of madecassoside are similar to those of asiaticoside in the mixture of methanol−water excluding those at high water content and high temperature. However, these two compounds with the only difference of 6-OH exhibit a quite different crystallization property that the induction period of madecassoside is at least 10 times longer than asiaticoside. Moreover, the interfacial tension data of asiaticoside were obtained, which are in the range of (0.55 to 0.86) mJ·m −2 .

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The effect of initial precipitates on the induction period of l-ornithine-l-aspartate during semi-batch drowning out crystallization

Cited by 7 publications

References 15 publications

Process Design for Antisolvent Crystallization of Erythromycin Ethylsuccinate in Oiling-out System

Process Design for Antisolvent Crystallization of Erythromycin Ethylsuccinate in Oiling-out System

Thermodynamic Modeling the Solid–Liquid Phase Equilibrium of a Water–Methanol–Potassium Dihydrogen Phosphate Ternary System with a Mixed-Solvent Electrolyte (MSE) Model

Solubility and Induction Period Study of Asiaticoside and Madecassoside in a Methanol + Water Mixture

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