The Effect of Inhaled Leukotriene D4, in Man

Modulation of CXCR4 expression and SDF-1α functional activity during differentiation of human monocytes and macrophages

“…10C). Significantly, both LTD 4 , an unrelated immunomodulator [31] and the CC chemokine MIP-1␣ were inhibited to a similar extent by PMA (Fig. 10B), consistent with PKC modulation of G-protein-coupled receptors.…”

The pharmacogenetics of asthma: a candidate gene approach

“…64 Although a variety of biological actions have been ascribed to LTB 4 , it is predominantly a chemotactic moiety for eosinophils and neutrophils; 65,66 these actions occur via signal transduction at the LTB 4 receptors. 67 The cysteinyl leukotrienes were identified as a result of the search for the chemical structure of the materials that constituted the contractile activity known as slow-reacting sub-stance of anaphylaxis (SRS-A) 60,61 and are among the most potent bronchoconstrictor substances ever identified; 68,69 their actions result from signal transduction at the CysLT 1 receptor. In addition, a myriad of other, mostly proinflammatory biological activities have been attributed to the cysteinyl leukotrienes, from mitogenic effects to the modification of vascular integrity (see reviews by Badr, 70 Bend & Karmazyn, 71 and Denzlinger 72 ).…”

Cysteinyl Leukotrienes Induce Nasal Symptoms of Allergic Rhinitis via a Receptor-Mediated Mechanism in Guinea Pigs

“…Therefore, the longer contact period of LTD4 to the nasal mucosa and use of allergic recipient could have changed the NAR response of recipients to LTD4. In fact, it has been demonstrated that allergic persons have an enhanced sen sitivity to LTD4 (14).…”