The effect of inhaled heliox on peak flow rates in normal and brachycephalic dogs

Benavides, Kathryn; Rozanski, Elizabeth A.; Anastasio, John D.; Bedenice, Daniela

doi:10.1111/jvim.15385

Cited by 2 publications

(2 citation statements)

References 7 publications

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“… 2010 ; Benavides et al. 2019 ). Expiratory or inspiratory flow at end TV plus 50% and 25% TV (EF50, IF50, EF25, IF25) was calculated by the software.…”

Section: Methodsmentioning

confidence: 99%

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Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy

Lin,

Johnson,

Chang

et al. 2023

Veterinary Quarterly

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Dynamic lower airway obstruction is the primary component of canine bronchomalacia, but the ventilatory function remains underinvestigated. This prospective study analyzed tidal breathing characteristics in 28 dogs, comprising 14 with severe bronchomalacia diagnosed by bronchoscopy versus 14 without respiratory disease. Spirometry was conducted in all dogs. Bronchoscopy with bronchoalveolar lavage or brush under anesthesia was performed in 14 dogs with cough and expiratory effort. Severe bronchomalacia was defined by the severity of collapse and total number of bronchi affected. Ventilatory characteristics were compared between groups. Results revealed that dogs with severe bronchomalacia had lower minute volume (218 vs 338 mL/kg, p = .039) and greater expiratory-to-inspiratory time ratio (1.55 vs 1.35, p = .01) compared to control dogs. The tidal breathing pattern of dogs with bronchomalacia was different from that of normal dogs, and the pattern differed from the concave or flat expiratory curves typical of lower airway obstruction. Compared to control dogs, dogs with severe bronchomalacia had a significantly prolonged low-flow expiratory phase ( p < .001) on the flow-time plot and a more exponential shape of the expiratory curve ( p < .001) on the volume-time plot. Flow-time index ExpLF/Te (>0.14) and volume-time index Vt-AUCexp (≤31%) had a high ROC-AUC (1.00, 95% confidence interval 0.88 to 1.00) in predicting severe bronchomalacia. In conclusion, the tidal breathing pattern identified here indicates abnormal and complicated ventilatory mechanics in dogs with severe bronchomalacia. The role of this pulmonary functional phenotype should be investigated for disease progression and therapeutic monitoring in canine bronchomalacia.

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“… 2010 ; Benavides et al. 2019 ). Expiratory or inspiratory flow at end TV plus 50% and 25% TV (EF50, IF50, EF25, IF25) was calculated by the software.…”

Section: Methodsmentioning

confidence: 99%

“… 2010 ; Benavides et al. 2019 ). However, ventilatory function has not yet been fully investigated in dogs with bronchomalacia.…”

Section: Introductionmentioning

confidence: 99%

Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy

Lin,

Johnson,

Chang

et al. 2023

Veterinary Quarterly

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Surgical management of brachycephalic obstructive airway syndrome: An update on options and outcomes

Wallace

2024

Veterinary Surgery

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Dogs with a brachycephalic conformation often experience a collection of abnormalities related to their craniofacial conformation, which can lead to a variety of clinical signs such as stertor, exercise intolerance, respiratory distress, and gastrointestinal signs such as regurgitation, among others. This collection of abnormalities is termed brachycephalic obstructive airway syndrome (BOAS). With the rise in popularity of several brachycephalic breeds, veterinarians and veterinary surgery specialists are seeing these dogs with increasing frequency for surgical and medical treatment of these clinical signs, leading to an increased interest in developing surgical techniques for dogs with BOAS and evaluating objective methods of determining outcome after surgery. Advances in anesthetic management including standardized protocols and use of local nerve blocks to decrease opiate use may decrease postoperative complications. A variety of new or modified surgical techniques to manage hyperplastic soft palate and stenotic nares, among other BOAS components, have been developed and studied in recent years. Newer studies have also focused on risk factors for development of major complications in the postoperative period and on objective measurements that may help determine which patients will receive the most benefit from BOAS surgery. In this review, the newest studies focused on updates in anesthetic management, surgical techniques, and postoperative care will be discussed. Additionally, updated information on complication rates and outcomes for dogs undergoing surgical management of BOAS will be included.

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The effect of inhaled heliox on peak flow rates in normal and brachycephalic dogs

Cited by 2 publications

References 7 publications

Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy

Quantifiable features of a tidal breathing phenotype in dogs with severe bronchomalacia diagnosed by bronchoscopy

Surgical management of brachycephalic obstructive airway syndrome: An update on options and outcomes

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