The effect of Indomethacin on the anterior segment of the eye after paracentesis

Abstract

The prostaglandin-inhibiting effect of Indomethacin (IN) was studied in rabbits, using paracentesis as a stimulus and rise in aqueous protein and fluorescein concentration after intravenous fluorescein injection as parameters. In eye pre-treated with IN eyedrops the rise in fluorescein and protein concentration in the secondary aqueous was less than the control eyes; the rise in the control eyes was less than in the eye of rabbits not treated with IN. There was good correlation between the rise in protein and the rise in fluorescein concentration in the secondary aqueous. The four different 0.5% IN suspensions used showed different PG-inhibiting activity, attributed to the difference in physiochemical composition.

The effect of topically applied prostaglandin inhibitors on the laser-induced disruption of the blood aqueous barrier

“…Probably this enzyme is partially liberated from another source, presumably the cellular material of the ocular tissue surrounding the anterior and posterior chambers. Lactate dehydrogenase is probably liberated directly after damage to the tissue and not by interaction with prostaglandins (6). In summary, the present investigation supports the use of topical administration of prostaglandin inhibitors in laser surgical procedure.…”

“…The efficacy of prostaglandin inhibitors in various inflammatory, mechanical, or chemical alterations of the blood-aqueous barrier is well established in the scientific literature (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). The present experimental study was designed to evaluate the preventive effects of different topically applied prostaglandin inhibitors on the barrier function after laser trauma.…”

Fluorophotometric and tonometric evaluation of ocular effects following aqueocentesis performed with needles of various sizes in dogs

“…31,35 The consensual ocular reaction is an important biological finding and is clinically noteworthy because it was documented immediately following and then up to 1 month after cataract surgery in humans. 32 Although it is commonly recognized that drugs applied topically to 1 eye can result in effects in the opposite eye, likely because of systemic absorption of the medication, [38][39][40][41][42][43] the present study is the first to suggest a consensual blood-aqueous barrier breakdown reaction in dogs.…”

Indomethacin eyedrops and the postoperative irritation after extracapsular cataract extraction combined with intraocular lens implantation

“…It has been proved that after intracapsular cataract extraction in humans and after paracentesis in rabbits, the blood-aqueous barrier is reestablished much earlier when Indomethacin eyedrops are used topically (Araie et at., 1981;Mochizuki et al, 1977;Oosterhuis et al, 1981;Sanders et al, 1982). Prostalandins have the following effects upon the eye: miosis, rise of intraocular pressure, vasodilation in iris and ciliary body, breakdown of blood-aqueous barrier and cystoid macular edema (Cole and Unger, 1973;Easty et al, 1977;Neufeld and Sears, 1973;Podos and Becker, 1976;Unger et al, 1975).…”