The effect of indocyanine green loaded on a novel nano-graphene oxide for high performance of photodynamic therapy against Enterococcus faecalis

Akbari, Tayebeh; Pourhajibagher, Maryam; Hosseini, Farzaneh; Chiniforush, Nasim; Gholibegloo, Elham; Khoobi, Mehdi; Shahabi, Sima; Bahador, Abbas

doi:10.1016/j.pdpdt.2017.08.017

Cited by 70 publications

(52 citation statements)

References 25 publications

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“…The anti-biofilm potential of NGO-ICG after light irradiation was 1.3 times higher than that of non-immobilized ICG (1000 µg•mL −1 ). The use of this new NIR photo-triggered drug delivery system has several advantages, such as its antimicrobial and anti-biofilm properties, cost-effectiveness, lower toxicity, and reduced teeth discoloration, and the authors recommend it as an adjuvant to conventional irrigation for endodontic treatment [57].…”

Section: Nano-graphene Oxidementioning

confidence: 99%

An Insight into Advanced Approaches for Photosensitizer Optimization in Endodontics—A Critical Review

Diogo

Faustino

Neves

et al. 2019

JFB

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Apical periodontitis is a biofilm-mediated disease; therefore, an antimicrobial approach is essential to cure or prevent its development. In the quest for efficient strategies to achieve this objective, antimicrobial photodynamic therapy (aPDT) has emerged as an alternative to classical endodontic irrigation solutions and antibiotics. The aim of the present critical review is to summarize the available evidence on photosensitizers (PSs) which has been confirmed in numerous studies from diverse areas combined with several antimicrobial strategies, as well as emerging options in order to optimize their properties and effects that might be translational and useful in the near future in basic endodontic research. Published data notably support the need for continuing the search for an ideal endodontic photosensitizer, that is, one which acts as an excellent antimicrobial agent without causing toxicity to the human host cells or presenting the risk of tooth discoloration. The current literature on experimental studies mainly relies on assessment of mixed disinfection protocols, combining approaches which are already available with aPDT as an adjunct therapy. In this review, several approaches concerning aPDT efficiency are appraised, such as the use of bacteriophages, biopolymers, drug and light delivery systems, efflux pump inhibitors, negative pressure systems, and peptides. The authors also analyzed their combination with other approaches for aPDT improvement, such as sonodynamic therapy. All of the aforementioned techniques have already been tested, and we highlight the biological challenges of each formulation, predicting that the collected information may encourage the development of other effective photoactive materials, in addition to being useful in endodontic basic research. Moreover, special attention is dedicated to studies on detailed conditions, aPDT features with a focus on PS enhancer strategies, and the respective final antimicrobial outcomes. From all the mentioned approaches, the two which are most widely discussed and which show the most promising outcomes for endodontic purposes are drug delivery systems (with strong development in nanoparticles) and PS solubilizers.

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Section: Nano-graphene Oxidementioning

confidence: 99%

An Insight into Advanced Approaches for Photosensitizer Optimization in Endodontics—A Critical Review

Diogo

Faustino

Neves

et al. 2019

JFB

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“…3). [82][83][84] In addition, these PSs also exhibit good fluorescence imaging capability and PTT effect, validating their broad application prospects in cancer treatment. 79 Targeted molecule-modified nanocarriers not only improve the stability and biocompatibility of PS but also deliver PS to the target cells to improve the curative effect and reduce side effects.…”

Section: Recent Advance Of Nanoparticle-based Pdtmentioning

confidence: 79%

“…ICG, IR820 and IR780 are multifunctional PS that rely on NIR laser (808 nm) irradiation with improved penetration and efficacy of PDT. [82][83][84] In addition, these PSs also exhibit good fluorescence imaging capability and PTT effect, validating their broad application prospects in cancer treatment. Several common nanomaterials, such as gold nanorods, which have been evaluated for their excellent PTT effect, are valuable in PDT.…”

Section: Recent Advance Of Nanoparticle-based Pdtmentioning

confidence: 79%

Nanoparticle‐based photothermal and photodynamic immunotherapy for tumor treatment

Hou

Tao

Pang

et al. 2018

Intl Journal of Cancer

186

123

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Nanoparticle-based phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), exhibit strong efficacy, minimal invasion and negligible side effects in tumor treatment. These phototherapies have received considerable attention and been extensively studied in recent years. In addition to directly killing tumor cells through heat and reactive oxygen species, PTT and PDT can also induce various antitumor effects. In particular, the resultant massive tumor cell death after PTT and PDT triggers immune responses, including the redistribution and activation of immune effector cells, the expression and secretion of cytokines and the transformation of memory T lymphocytes. The antitumor effects can be enhanced by immune checkpoint blockage therapy. This article reviewed the recent advances of nanoparticle-based PTT and PDT, summarized the studies on nanoparticle-based photothermal and photodynamic immunotherapies in vitro and in vivo, and discussed challenges and future research directions.

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“…Rose Bengal was used in six studies [ 9 , 16 , 18 , 29 , 32 , 33 ]. Three studies used Indocyanine green [ 31 , 34 , 35 ], and one of them used Indocyanine green loaded on nano-graphene oxide [ 35 ]. Two studies reported the effect of chitosan-Rose Bengeal conjugate [ 9 , 32 ] and two other studies used Rose Bengal functionalized chitosan nanoparticles [ 18 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…One study involved mono- and dual-species biofilm [ 16 ], and one study on multispecies biofilms [ 18 ]. The selected studies in this section addressed the effect of LAD on established biofilms except two studies, which demonstrated the inhibition of biofilm formation by light activated disinfection [ 31 , 35 ]. Table 3 summarizes the general characteristics of these studies.…”

Section: Resultsmentioning

confidence: 99%

Light Activated Disinfection in Root Canal Treatment—A Focused Review

Ali

Neelakantan

2018

Dentistry Journal

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Light activated disinfection (LAD) is a strategy for optimizing root canal disinfection by using a highly-selective, targeted killing of bacteria using a combination of photosensitizers and light. Over the past decade, numerous in vitro and clinical studies have been performed to demonstrate the effectiveness of this mode of root canal disinfection. While most studies offer an important understanding of the effectiveness of LAD on monospecies biofilms, few have offered credence to the fact that infections of the root canal system are mediated by polymicrobial biofilms. Hence, it is imperative to understand the effect of LAD on polymicrobial biofilms both in terms of microbial killing and the changes in the biofilm architecture. The aim of this review was to systematically review the literature to evaluate the effect of LAD on dual and multispecies biofilms and demonstrate the antibiofilm effect of LAD. Two databases (PubMed and Scopus) were searched to identify eligible studies using a combination of key words. These studies were reviewed to draw conclusions on the effect of LAD on dual and multi species biofilm and the antibiofilm effect of LAD. It was found that LAD alone may be unable to eradicate dual and multispecies biofilms, but it may enhance the effect of conventional canal debridement strategies. Novel formulations of photosensitizers with nanoparticles showed the potential to inhibit biofilm formation and/or disrupt the biofilm architecture.

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The effect of indocyanine green loaded on a novel nano-graphene oxide for high performance of photodynamic therapy against Enterococcus faecalis

Cited by 70 publications

References 25 publications

An Insight into Advanced Approaches for Photosensitizer Optimization in Endodontics—A Critical Review

An Insight into Advanced Approaches for Photosensitizer Optimization in Endodontics—A Critical Review

Nanoparticle‐based photothermal and photodynamic immunotherapy for tumor treatment

Light Activated Disinfection in Root Canal Treatment—A Focused Review

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