The effect of indapamide <i>vs</i>. bendroflumethiazide for primary hypertension: a systematic review

Macfarlane, Tatiana V.; Pigazzani, Filippo; Flynn, Robert; MacDonald, Thomas M.

doi:10.1111/bcp.13787

Cited by 14 publications

(12 citation statements)

References 56 publications

(98 reference statements)

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“…Herein, we can understand the mechanisms of the drugs which were predicted in the present study based on the above discussion. Trichlormethiazide and bendroflumethiazide are both inhibitors for CAs [90,91]. Application of CA inhibitors in COVID-19 individuals can block the discharge of H+ in the kidney and worsen the acidotic status in patients [92].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of the Systemic Transcriptomic Alternations and Inflammatory Response during the Occurrence and Progress of COVID‐19

Dai

Wang

et al. 2021

Oxidative Medicine and Cellular Longevity

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The pandemic of the coronavirus disease 2019 (COVID-19) has posed huge threats to healthcare systems and the global economy. However, the host response towards COVID-19 on the molecular and cellular levels still lacks full understanding and effective therapies are in urgent need. Here, we integrate three datasets, GSE152641, GSE161777, and GSE157103. Compared to healthy people, 314 differentially expressed genes were identified, which were mostly involved in neutrophil degranulation and cell division. The protein-protein network was established and two significant subsets were filtered by MCODE: ssGSEA and CIBERSORT, which comprehensively revealed the alternation of immune cell abundance. Weighted gene coexpression network analysis (WGCNA) as well as GO and KEGG analyses unveiled the role of neutrophils and T cells during the progress of the disease. Based on the hospital-free days after 45 days of follow-up and statistical methods such as nonnegative matrix factorization (NMF), submap, and linear correlation analysis, 31 genes were regarded as the signature of the peripheral blood of COVID-19. Various immune cells were identified to be related to the prognosis of the patients. Drugs were predicted for the genes in the signature by DGIdb. Overall, our study comprehensively revealed the relationship between the inflammatory response and the disease course, which provided strategies for the treatment of COVID-19.

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Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of the Systemic Transcriptomic Alternations and Inflammatory Response during the Occurrence and Progress of COVID‐19

Dai

Wang

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…perpetuity. preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in The copyright holder for this this version posted August 25, 2021. ; https://doi.org/10.1101/2021.08.19.21262289 doi: medRxiv preprint recent meta-analysis by our group, whilst highlighting the need for further research, demonstrated no difference in outcomes between indapamide and bendroflumethiazide (16).…”

Section: Rationale For Evidencementioning

confidence: 75%

Evaluating Diuretics in Normal Care (EVIDENCE): A feasibility report of a pilot cluster randomised trial of prescribing policy in primary care to compare the effectiveness of thiazide-type diuretics in hypertension

Flynn

Rogers

McConnachie

et al. 2021

Preprint

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Background Obtaining evidence on comparative effectiveness and safety of widely prescribed drugs in a timely and cost-effective way is a major challenge for healthcare systems. Here we describe the feasibility of the Evaluating Diuretics in Normal Care (EVIDENCE) study that compares a thiazide and thiazide-like diuretics for hypertension as an exemplar of a more general framework for efficient generation of such evidence. In 2011, the UK NICE hypertension guideline included a recommendation that thiazide-like diuretics (such as indapamide) be used in preference to thiazide diuretics (such as bendroflumethiazide) for hypertension. There is sparse evidence backing this recommendation, and bendroflumethiazide remains widely used in the UK. Methods Patients prescribed indapamide or bendroflumethiazide regularly for hypertension were identified in participating General Practices. Allocation of a prescribing policy favouring one of these drugs was then randomly applied to the Practice and, where required to comply with the policy, repeat prescriptions switched by pharmacy staff. Patients were informed of the potential switch by letter and given the opportunity to opt-out. Practice adherence to the randomised policy was assessed by measuring the amount of policy drug prescribed as a proportion of total combined indapamide and bendroflumethiazide. Routinely collected hospitalization and death data in the NHS will be used to compare cardiovascular event rates between the two policies. Results This pilot recruited 30 primary care practices in five Scottish National Health Service (NHS) Boards. Fifteen practices were randomised to indapamide (2682 patients), and 15 to bendroflumethiazide (3437 patients); a study population of 6119 patients. Prior to randomisation, bendroflumethiazide was prescribed to 78% of patients prescribed either of these drugs. Only 1.6% of patients opted out of the proposed medication switch. Conclusion The pilot and subsequent recruitment confirms the methodology is scalable within NHS Scotland for a fully powered larger study, currently 102 GP practices (>12,700 patients) are participating in this study. It has the potential to efficiently produce externally valid comparative effectiveness data with minimal disruption to practice staff or patients. Streamlining this pragmatic trial approach, has demonstrated the feasibility of a random prescribing policy design framework that can be adapted to other therapeutic areas. Keywords: pilot, prescribing policy, comparative effectiveness, drug prescriptions, primary care, hypertension

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“…[33] In this study, 20% patient were detected obese (Table 3). Peart SS et al [34] had shown that the obesity has significant contribution to the risk of stroke of untreated patient of either sex. So findings in this study correlate well with above mentioned study.…”

Section: Discussionmentioning

confidence: 99%

Study on Risk Factor Evaluation of Ischaemic Stroke Patients Admitted in a Tertiary Care Hospital: 100 Cases

Shah¹,

Matin²,

Islam³

et al. 2020

AJBLS

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Background: Stroke is defined as a sudden onset focal neurological deficit of vascular etiology and is a major cause of mortality and morbidity around the globe. The aim of this study was to find out the proportion of major risk factor or factors related in infarctive stroke cases. Methods: This hospital based descriptive cross sectional study was carried out in one hundred (100) ischemic stroke patients admitted in Medicine units associated with Neurology ward in Enam Medical College & Hospital, Savar, Dhaka, Bangladesh during the period from January 2015 to September 2017. Permission for the study was taken from the mentioned departments and authorities. Subjects were selected in all age groups and both male and female patients to whom duration of illness were less than 72 hours. Results: Among all, 61% were male and 39% were female and male female ratio 1.56:1. The maximum number of patients (36%) were in between 61-70 years of age. Majority of the patients (40%) came from middle class (TK. 7000-10,000/Month). A significant number of patients had high level of lipid profile e.g. Total cholesterol (>200 mg/dl) 73.33%, LDL (>150 mg/dl) 60%, TG (>150 mg/dl) 70%. In many cases multiple risk factors were present. It was observed that hypertension was the most common major risk factor for stroke. Among the 60% of the hypertensive patients only 45% were controlled with treatment and 33.33% were uncontrolled with treatment and 21.66% did not take any medicine or measures. About 47% were smoker. Diabetes mellitus was detected in 26% of patients which is lower than hypertension and hyperlipidaemia. About 25% of patient had history of previous stroke and 20% patient had family history of stroke. Only 6% was alcoholic. Among the female patients 5% received oral pills. Conclusion: Hypertension is one of the major risk factors for the stroke. For the management and prevention of hypertension like stroke, we are recommending the following measures like Hypertension screening programme for early detection, management and follow up and increase awareness regarding hypertension and its complication. It should be controlled by personal motivation, anti-smoking campaign, banding of the smoking propaganda in the TV, Radio, News paper, poster, banner, leaflet etc. Ensure punishment for smoking in open public places and public transports.

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The effect of indapamide vs. bendroflumethiazide for primary hypertension: a systematic review

Cited by 14 publications

References 56 publications

Comprehensive Analysis of the Systemic Transcriptomic Alternations and Inflammatory Response during the Occurrence and Progress of COVID‐19

Comprehensive Analysis of the Systemic Transcriptomic Alternations and Inflammatory Response during the Occurrence and Progress of COVID‐19

Evaluating Diuretics in Normal Care (EVIDENCE): A feasibility report of a pilot cluster randomised trial of prescribing policy in primary care to compare the effectiveness of thiazide-type diuretics in hypertension

Study on Risk Factor Evaluation of Ischaemic Stroke Patients Admitted in a Tertiary Care Hospital: 100 Cases

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