The Effect of Increasing Time of Development at Constant Temperature on the Wing Size of Vestigial of Drosophila Melanogaster

Child, George P.

doi:10.2307/1537653

Cited by 11 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Differences between reciprocal crosses somewhat similar to those encountered in this work have also been described for vg by Hersh andWard (1932), andChild (1939). No data were presented dealing with differences in wing size related to eclosion order, or to amount of substrate per larva, nor have tests of homogeneity been reported.…”

Section: Discussionsupporting

confidence: 74%

The Problem of Differences of Offspring in Reciprocal Crosses of Drosophila

Stone¹

1947

The Biological Bulletin

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 74%

The Problem of Differences of Offspring in Reciprocal Crosses of Drosophila

Stone¹

1947

The Biological Bulletin

View full text Add to dashboard Cite

“…As first noted by T.H. Morgan, morphological phenotypes can be suppressed by limiting the nutrition of mutant animals (Child, 1939;Morgan, 1915;Morgan, 1929;Sang and Burnet, 1963). Likewise, raising animals under lowered temperatures can sometimes suppress the phenotypes of mutations that are not classical ts alleles (Child, 1935;Krafka, 1920;Lewis et al, 1980;Villee, 1943).…”

Section: Introductionmentioning

confidence: 92%

Repressive Gene Regulation Synchronizes Development with Cellular Metabolism

Cassidy

Bernasek

Bakker

et al. 2019

Cell

View full text Add to dashboard Cite

Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that layered weak repression of genes provides the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that replicates such a scenario, we find that lowering metabolism corrects developmental errors that otherwise occur when different layers of repression are lost. Through mutant analysis, we show that gene expression dynamics are unaffected by loss of repressors, but only when cellular metabolism is reduced. We further show that when metabolism is lowered, formation of a variety of sensory organs in Drosophila is normal despite loss of individual repressors of transcription, mRNA stability, and protein stability. We demonstrate the universality of this phenomenon by experimentally eliminating the entire microRNA family of repressors, and find that all microRNAs are rendered unnecessary when metabolism is reduced. Thus, layered weak repression provides robustness through error frequency suppression, and may provide an evolutionary route to a shorter reproductive cycle. ! 2. CC-BY-ND 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.

show abstract

Section: Introductionmentioning

confidence: 92%

Repressive gene regulation synchronizes development with cellular metabolism

Cassidy¹,

Bernasek²,

Bakker³

et al. 2019

Preprint

View full text Add to dashboard Cite

Metabolic conditions affect the developmental tempo of most animal species. Consequently, developmental gene regulatory networks (GRNs) must faithfully adjust their dynamics to a variable time scale. We find evidence that layered weak repression of genes provides the necessary coupling between GRN output and cellular metabolism. Using a mathematical model that replicates such a scenario, we find that lowering metabolism corrects developmental errors that otherwise occur when different layers of repression are lost. Through mutant analysis, we show that gene expression dynamics are unaffected by loss of repressors, but only when cellular metabolism is reduced. We further show that when metabolism is lowered, formation of a variety of sensory organs in Drosophila is normal despite loss of individual repressors of transcription, mRNA stability, and protein stability. We demonstrate the universality of this phenomenon by experimentally eliminating the entire microRNA family of repressors, and find that all microRNAs are rendered unnecessary when metabolism is reduced. Thus, layered weak repression provides robustness through error frequency suppression, and may provide an evolutionary route to a shorter reproductive cycle.Reduced glucose consumption by cells might not only limit ATP fluxes, but also hinder the synthesis of nucleotide and amino acid precursors required for RNA and protein synthesis. To simulate this scenario, we specifically reduced the rate parameters ! 13 ! 14 ! 15 ! 16 ! 17

show abstract

The Effect of Increasing Time of Development at Constant Temperature on the Wing Size of Vestigial of Drosophila Melanogaster

Cited by 11 publications

References 12 publications

The Problem of Differences of Offspring in Reciprocal Crosses of Drosophila

The Problem of Differences of Offspring in Reciprocal Crosses of Drosophila

Repressive Gene Regulation Synchronizes Development with Cellular Metabolism

Repressive gene regulation synchronizes development with cellular metabolism

Contact Info

Product

Resources

About