The effect of increased vascular pressure on albumin-excluded volume and lymph flow in the dog lung.

Parker, James C.; Falgout, H J; Grimbert, FA; Taylor, Aubrey E.

doi:10.1161/01.res.47.6.866

Cited by 36 publications

(17 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Negrini et al (321) found a high excluded volume fraction of 0.66 in control situation compared with previous values of ϳ0.38 in dog lung (353,354), a finding that led them to conclude that the lung interstitium must have a tight fibrous structure that is highly restrictive with respect to plasma protein distribution. In another study they found that the albumin distribution volume was highly sensitive to hydration, since an increase in V i of 39% reduced the excluded volume fraction to 33% of the control value (320).…”

Section: Interstitial Volume Exclusion In Tail Tendon and Rabbit Lungmentioning

confidence: 85%

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

Wiig

Swartz²

2012

Physiological Reviews

569

574

View full text Add to dashboard Cite

The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that comprise the cellular microenvironment in tissues. Its alterations are fundamental to changes in cell function in inflammation, pathogenesis, and cancer. Interstitial fluid (IF) is created by transcapillary filtration and cleared by lymphatic vessels. Herein we discuss the biophysical, biomechanical, and functional implications of IF in normal and pathological tissue states from both fluid balance and cell function perspectives. We also discuss analysis methods to access IF, which enables quantification of the cellular microenvironment; such methods have demonstrated, for example, that there can be dramatic gradients from tissue to plasma during inflammation and that tumor IF is hypoxic and acidic compared with subcutaneous IF and plasma. Accumulated recent data show that IF and its convection through the interstitium and delivery to the lymph nodes have many and diverse biological effects, including in ECM reorganization, cell migration, and capillary morphogenesis as well as in immunity and peripheral tolerance. This review integrates the biophysical, biomechanical, and biological aspects of interstitial and lymph fluid and its transport in tissue physiology, pathophysiology, and immune regulation.

show abstract

Section: Interstitial Volume Exclusion In Tail Tendon and Rabbit Lungmentioning

confidence: 85%

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

Wiig

Swartz²

2012

Physiological Reviews

569

574

View full text Add to dashboard Cite

show abstract

“…As summarized previously [ 4 ], one issue of debate is how perturbations of fluid balance can affect the excluded volume, i.e., is the excluded volume fraction constant or is it changing as a function of changes in interstitial fluid volume. Whereas previous work by Parker et al from the lung had shown a reduced fractional exclusion during overhydration [ 57 , 58 ], the studies from Bell et al gave a variable albumin exclusion depending on the experimental procedure [ 8 , 9 , 49 , 50 ]. This question was addressed by Reed and colleagues [ 66 ], who measured albumin exclusion in rat subcutis and dermis over a wide range of hydrations.…”

Section: Available and Excluded Volume Of Macromoleculesmentioning

confidence: 99%

The Role of the Extracellular Matrix in Tissue Distribution of Macromolecules in Normal and Pathological Tissues: Potential Therapeutic Consequences

et al. 2008

View full text Add to dashboard Cite

The interstitial space is a dynamic microenvironment that consists of interstitial fluid and structural molecules of the extracellular matrix, such as glycosaminoglycans (hyaluronan and proteoglycans) and collagen. Macromolecules can distribute in the interstitium only in those spaces unoccupied by structural components, a phenomenon called interstitial exclusion. The exclusion phenomenon has direct consequences for plasma volume regulation. Early studies have assigned a major role to collagen as an excluding agent that accounts for the sterical (geometrical) exclusion. More recently, it has been shown that the contribution of negatively charged glycosaminoglycans might also be significant, resulting in an additional electrostatical exclusion effect. This charge effect may be of importance for drug uptake and suggests that either the glycosaminoglycans or the net charge of macromolecular substances to be delivered may be targeted to increase the available volume and uptake of macromolecular therapeutic agents in tumor tissue. Here, we provide an overview of the structural components of the interstitium and discuss the importance the sterical and electrostatical components have on the dynamics of transcapillary fluid exchange.

show abstract

“…Increased leakage of albumin may result in increased oncotic buffering by allowing greater access of albumin to the interstitial tissue volume, leading to dilution, decreased interstitial colloid oncotic pressure and an increase in the oncotic gradients (14). Potentially, the increased interstitial volume and pressure resulting from pulmonary endothelial barrier dysfunction may increase the resistance against further leakage of injected radiolabeled albumin.…”

Section: Does Endothelial Barrier Dysfunction Play a Central Role?mentioning

confidence: 99%

A new understanding of pancreatitis-associated pulmonary injury

Zhao¹,

Shi²,

Wang³

et al. 2006

Journal of Organ Dysfunction

View full text Add to dashboard Cite

Pancreatitis-associated lung injury (PALI) is one of the earliest organ dysfunctions occurring in patients with severe acute pancreatitis. In this review we explore potential mechanisms of endothelial barrier dysfunction, neutrophil and monocyte/ macrophage activation, adhesion molecule expression, initial factors, mast cell involvement and intracellular signaling in PALI. Different regulatory mechanisms exist in PALI and sepsis-induced lung injury. Endothelial barrier dysfunction occurs early on in acute pancreatitis and tumor necrosis factor (TNF)-a and monocyte chemoattractive protein-1 levels in the circulation gradually increase in acute pancreatitis. Leukocytes from the circulation, lung tissue and bronchoalveolar fluid exhibit different expression and activation patterns in the development of PALI. Mast cells seem to be involved in the initiation of leukocyte activation during the initial phase of PALI. Activation of the protein kinase C (PKC) signaling pathway could play an important role in the pathogenesis of PALI. Inhibition of PKC may be one candidate to prevent and treat the development of PALI.

show abstract

The effect of increased vascular pressure on albumin-excluded volume and lymph flow in the dog lung.

Cited by 36 publications

References 13 publications

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

The Role of the Extracellular Matrix in Tissue Distribution of Macromolecules in Normal and Pathological Tissues: Potential Therapeutic Consequences

A new understanding of pancreatitis-associated pulmonary injury

Contact Info

Product

Resources

About