The effect of in vivo ethanol consumption on cyclic AMP and δ-opioid receptors in mouse striatum

Shen, Jing; Chan, Ka Wa; Chen, Billy T.; Philippe, Jacques; Sehba, Fatima A.; Duttaroy, Alokesh; Carroll, Joanne; Yoburn, Byron C.

doi:10.1016/s0006-8993(97)00747-6

Cited by 12 publications

(4 citation statements)

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“…Chronic exposure to ethanol did not change delta transcripts in the striatum (337, 411) or HPT (411) of these animals. Interestingly, 3 wk after the cessation of ethanol consumption, delta receptor transcripts were increased in the striatum of alcohol-avoiding but not -preferring mice (411).…”

Section: Modifications Of Opioid System Gene Expression Under Chromentioning

confidence: 75%

“…Basal levels of mu receptor transcripts were similar between preferring and nonpreferring strains in the HPT and striatum (52, 141, 411) as well as in the NAc, hippocampus (HPC), frontal cortex (FrCx), but not inferior colliculus, where higher levels were observed in alcohol-preferring animals (141). Following chronic ethanol, mu receptor transcripts were unchanged in the striatum of both strains (337, 411), but decreased in the HPT, an effect still measurable up to 3 wk after cessation of ethanol consumption, specifically in the alcohol-preferring animals (411). …”

Section: Modifications Of Opioid System Gene Expression Under Chromentioning

confidence: 97%

See 1 more Smart Citation

Reward Processing by the Opioid System in the Brain

Merrer¹,

Becker²,

Befort³

et al. 2009

Physiological Reviews

831

676

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The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides processed from three protein precursors, proopiomelanocortin, proenkephalin, and prodynorphin. Opioid receptors are recruited in response to natural rewarding stimuli and drugs of abuse, and both endogenous opioids and their receptors are modified as addiction develops. Mechanisms whereby aberrant activation and modifications of the opioid system contribute to drug craving and relapse remain to be clarified. This review summarizes our present knowledge on brain sites where the endogenous opioid system controls hedonic responses and is modified in response to drugs of abuse in the rodent brain. We review 1) the latest data on the anatomy of the opioid system, 2) the consequences of local intracerebral pharmacological manipulation of the opioid system on reinforced behaviors, 3) the consequences of gene knockout on reinforced behaviors and drug dependence, and 4) the consequences of chronic exposure to drugs of abuse on expression levels of opioid system genes. Future studies will establish key molecular actors of the system and neural sites where opioid peptides and receptors contribute to the onset of addictive disorders. Combined with data from human and nonhuman primate (not reviewed here), research in this extremely active field has implications both for our understanding of the biology of addiction and for therapeutic interventions to treat the disorder.

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Section: Modifications Of Opioid System Gene Expression Under Chromentioning

confidence: 75%

Section: Modifications Of Opioid System Gene Expression Under Chromentioning

confidence: 97%

Reward Processing by the Opioid System in the Brain

Merrer¹,

Becker²,

Befort³

et al. 2009

Physiological Reviews

831

676

View full text Add to dashboard Cite

show abstract

“…Prolonged alcohol exposure on the other hand decreases met-enkephalin levels in the striatum of rats (Seizinger et al 1983; Schulz et al 1980), but will return to baseline after withdrawal (Schulz et al 1980). However, in mice, relatively short access to 7% alcohol did not have a large effect on DOR expression or activity in the striatum (Shen et al 1997). Still, in rats, endogenous opioids acting on DORs in the striatum are suggested to increase alcohol intake.…”

Section: Neuroanatomical Analysis Of Delta Opioid Receptor-induced mentioning

confidence: 99%

Delta Opioid Pharmacology in Relation to Alcohol Behaviors

Alongkronrusmee

Chiang

Rijn

2016

Handbook of Experimental Pharmacology

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Delta opioid receptors (DORs) are heavily involved in alcohol-mediated processes in the brain. In this chapter we provide an overview of studies investigating how alcohol directly impacts DOR pharmacology and of early studies indicating DOR modulation of alcohol behavior. We will offer a brief summary of the different animal species used in alcohol studies investigating DORs followed by a broader overview of the types of alcohol behaviors modulated by DORs. We will highlight a small set of studies investigating the relationship between alcohol and DORs in analgesia. We will then provide an anatomical overview linking DOR expression in specific brain regions to different alcohol behaviors. In this section, we will provide two models that try to explain how endogenous opioids acting at DORs may influence alcohol behaviors. Next, we will provide an overview of studies investigating certain new aspects of DOR pharmacology, including the formation of heteromers and biased signaling. Finally, we provide a short overview of the genetics of the DORs in relation to alcohol use disorders (AUDs) and a short statement on the potential of using DOR-based therapeutics for treatment of AUDs.

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“…Moreover, DOR function is enhanced in the central nucleus of the amygdala (Bie et al 2009a), ventral tegmental area (Margolis et al 2008), striatum (Nielsen et al 2012) and spinal cord (van Rijn et al 2012b) after long term ethanol consumption. Yet, functional DORs may already be present in naïve animals based on GTPγS activation studies in several brain regions including, cortex (Nielsen et al 2012) hippocampus, cerebellum and colliculus (Saland et al 2004) as well as cAMP inhibition studies in striatum (Shen et al 1997) and electrophysiology performed in the central nucleus of the amygdala (Kang-Park et al 2007). Margolis and co-workers found that rats that consume large amounts of ethanol are in general more anxious and express fewer functional DORs in the ventral tegmental area (Margolis et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Pharmacological traits of delta opioid receptors: pitfalls or opportunities?

2013

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Delta opioid receptors (DORs) have been considered as a potential target to relieve pain as well as treat depression and anxiety disorders, and are known to modulate other physiological responses, including ethanol and food consumption. A small number of DOR selective drugs are in clinical trials, but no DOR selective drugs have been approved by the Federal Drug Administration and some candidates have failed in phase II clinical trials, highlighting current difficulties producing effective delta opioid based therapies. Recent studies have provided new insights into the pharmacology of the DOR, which is often complex and at times paradoxical. This review will discuss the existing literature focusing on four aspects: 1) Two DOR subtypes have been postulated based on differences in pharmacological effects of existing DOR-selective ligands 2) DORs are expressed ubiquitously throughout the body and central nervous system and are, thus, positioned to play a role in a multitude of diseases. 3) DOR expression is often dynamic, with many reports of increased expression during exposure to chronic stimuli, such as stress, inflammation, neuropathy, morphine, or changes in endogenous opioid tone. 4) A large structural variety in DOR ligands implies potential different mechanisms of activating the receptor. These combined features of DOR pharmacology illustrate the potential benefit of designing tailored or biased DOR ligands.

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The effect of in vivo ethanol consumption on cyclic AMP and δ-opioid receptors in mouse striatum

Cited by 12 publications

References 40 publications

Reward Processing by the Opioid System in the Brain

Reward Processing by the Opioid System in the Brain

Delta Opioid Pharmacology in Relation to Alcohol Behaviors

Pharmacological traits of delta opioid receptors: pitfalls or opportunities?

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