The effect of immobilized platelet derived growth factor AA on neural stem/progenitor cell differentiation on cell-adhesive hydrogels

Aizawa, Yukie; Leipzig, Nic D.; Zahir, Tasneem; Shoichet, Molly S.

doi:10.1016/j.biomaterials.2008.08.018

Cited by 72 publications

(73 citation statements)

References 34 publications

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“…Shoichet and co-workers have exploited this click reaction for 3D patterning of agarose hydrogels 92,93,100,121 . Covalent modification of agarose with S-2-nitrobenzyl-cysteine (S-NBC) renders a photolabile matrix, which upon UV irradiation, releases free thiols capable of reacting with any thiol-reactive biomolecule through Michael addition.…”

Section: Thiol-maleimide Click Patterningmentioning

confidence: 99%

“…This immobilized RGD channel volume promoted neurite extension and cell migration 92 . This system was also applied to study the effect of immobilized platelet derived growth factor AA (PDGF-AA) on neural stem/progenitor cell (NSPC) differentiation 121 . Hydrogels with immobilized RGD and PDGF-AA supported NSPC adhesion and preferential differentiation to oligodendrocytes.…”

Section: Thiol-maleimide Click Patterningmentioning

confidence: 99%

“…Notably, the effect of peptide presentation on the cell has been examined by spatially immobilizing proteins and adhesion peptides in 3D patterns within scaffolds. Growth factors localized in 3D scaffolds remain bioactive [121][122][123] and have been shown to orient axonal growth 92,99 , guide cellular migration 91 , and cause morphological changes 38 . The stringent spatial resolution and controlled biochemical heterogeneity required for 3D patterning make simple bioorthogonal chemistries paramount.…”

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confidence: 99%

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Diels−Alder Click Cross-Linked Hyaluronic Acid Hydrogels for Tissue Engineering

2011

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Hyaluronic acid (HA) is a naturally occurring polymer that holds considerable promise for tissue engineering applications. Current cross-linking chemistries often require a coupling agent, catalyst, or photoinitiator, which may be cytotoxic, or involve a multistep synthesis of functionalized-HA, increasing the complexity of the system. With the goal of designing a simpler one-step , aqueous-based cross-linking system, we synthesized HA hydrogels via Diels-Alder "click" chemistry. Furan-modified HA derivates were synthesized and cross-linked via dimaleimide poly(ethylene glycol). By controlling the furan to maleimide molar ratio, both the mechanical and degradation properties of the resulting Diels-Alder cross-linked hydrogels can be tuned. Rheological and degradation studies demonstrate that the Diels-Alder click reaction is a suitable cross-linking method for HA. These HA cross-linked hydrogels were shown to be cytocompatible and may represent a promising material for soft tissue engineering.iii

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Section: Thiol-maleimide Click Patterningmentioning

confidence: 99%

Section: Thiol-maleimide Click Patterningmentioning

confidence: 99%

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confidence: 99%

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Diels−Alder Click Cross-Linked Hyaluronic Acid Hydrogels for Tissue Engineering

2011

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“…NSCs cultured on agarose scaffold immobilised with RGD and platelet derived growth factor AA (PDGF-AA) showed differentiation into oligodendrocytes, being confirmed at a protein and gene level [75] . Nerve growth factor (NGF) immobilised onto nanofibrous polycaprolactone-polyethylene glycol (PCL/PCL-PEG) scaffolds also induced the neural differentiation of MSCs [76] .…”

Section: A B Cmentioning

confidence: 99%

“…Curran et al [66] Peptide sequence Alginate Osteopontin peptide Increase in hMSC osteogenic markers Lee et al [67] HA-PLG Osteocalcin peptide Increase hMSC osteogenic markers Lee et al [68] PLGA BMP-2 peptide Increase rMSC ALP expression in osteogenic medium and promotion of ectopic bone formation in vivo Lin et al [15] RGD BCP/PLA hMSC osteogenic differentiation Shin et al [70] Molecule PLGA BMP-2 hMSC osteogenic differentiation Ko et al [71] PLLA BMP-2 hMSC osteogenic differentiation Beazley et al [16] Collagen-PLGA hybrid Collagen-binding domain derived from fibronectin (CBD-BMP4) hMSC osteogenic differentiation Lu et al [72] Methacrylamide chitosan hydrogel coated glass substrates Laminin and collagen Supported hNSC differentiation Wilkinson et al [73] PMMA-g-PEG EGF MSC osteogenic differentiation Platt et al [74] Agarose PDGF-AA MSC neural differentiation Aizawa et al [75] PCL/PCL-PEG NGF MSC neural differentiation Cho et al [76] Chitosan/collagen Ⅳ VEGF Endothelial differentiation Chiang et al [77] , Poh et al [78] , Rahman et al [79] hESC: Human embryonic stem cell; hMSC: Human mesenchymal stem cell; rMSCs: Rat mesenchymal stem cell; hNSC: Human neural stem cell; PEG: Polyethylene glycol; HA-PLG: Hydroxyapatite (HA)/poly(lactic-co-glycolic acid); BMP: Bone morphogenetic protein; PLGA: Poly(lactic-co -g lycolic acid); PLA: Poly(lactic acid); PLLA: Poly(L-lactide); PCL: Polycaprolactone; PMMA-g-PEG: Poly(methyl methacrylate)-graft-poly(ethylene glycol; BCP: Biphasic calcium phosphate; EGF: Epidermal growth factor; NGF: Nerve growth factor; PDGF-AA: Platelet-derived Growth Factor AA; VEGF: Vascular endothelial growth factor.…”

Section: Neuronalmentioning

confidence: 99%

Control of stem cell fate by engineering their micro and nanoenvironment

Griffin

Butler

Seifalian

et al. 2015

WJSC

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Stem cells are capable of long-term self-renewal and differentiation into specialised cell types, making them an ideal candidate for a cell source for regenerative medicine. The control of stem cell fate has become a major area of interest in the field of regenerative medicine and therapeutic intervention. Conventional methods of chemically inducing stem cells into specific lineages is being challenged by the advances in biomaterial technology, with evidence highlighting that material properties are capable of driving stem cell fate. Materials are being designed to mimic the clues stem cells receive in their in vivo stem cell niche including topographical and chemical instructions. Nanotopographical clues that mimic the extracellular matrix (ECM) in vivo have shown to regulate stem cell differentiation. The delivery of ECM components on biomaterials in the form of short peptides sequences has also proved successful in directing stem cell lineage. Growth factors responsible for controlling stem cell fate in vivo have also been delivered via biomaterials to provide clues to determine stem cell differentiation. An alternative approach to guide stem cells fate is to provide genetic clues including delivering DNA plasmids and small interfering RNAs via scaffolds. This review, aims to provide an overview of the topographical, chemical and molecular clues that biomaterials can provide to guide stem cell fate. The promising features and challenges of such approaches will be highlighted, to provide directions for future advancements in this exciting area of stem cell translation for regenerative medicine.

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