The effect of <i>Rheum ribes</i> L. on oxidative stress in diabetic rats

Yıldırım, Metin; Değirmenci, Ulaş; Akkapulu, Merih; Çömelekoğlu, Ülkü; Ballı, Ebru; Ozcan, Tuba; Berköz, Mehmet; Yalın, Ali Erdinç; Yalın, Serap

doi:10.1515/jbcpp-2020-0058

Cited by 14 publications

(10 citation statements)

References 24 publications

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“…Thus, the hypoglycemic effect of R. Ribes extract may result from its insulin-enhancing effect and its potent antioxidant property. [20,22] Besides, the present study has shown that the i.p. administration of U. Dioica aqueous-alcoholic extract for 21 days could decrease the FBG level significantly.…”

Section: Discussionsupporting

confidence: 55%

“…Results showed that oral administration of 50 mg/kg R. Ribes both aqueous and ethanolic extracts for 15 days could significantly decrease the FBG and oxidative stress activity and increase the levels of antioxidants. [20] Moreover, the effect of oral administration of R. ribes roots different extracts in 5 mg/kg doses on blood glucose level and insulin secretion rate of healthy mice was evaluated. The results have shown that only the aqueous extract of R. Ribes showed hypoglycemic activity and enhanced the secretion of insulin.…”

Section: Discussionmentioning

confidence: 99%

“…[17,19] Multiple studies have shown that R. Ribes roots have antidiabetic activity, including antihyperglycemic, insulin-releasing, and antiretinopathic activities. [20][21][22][23] Urtica Dioica (U. Dioica) is another medicinal plant, which belongs to the Urticaceae family. This plant is also famous for its use as a food ingredient and herbal drug.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Hussaini¹,

Askndari²,

Alami³

et al. 2021

Int j pharm phytopharm res

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The prevalence of type 2 diabetes is increasing and considered a major cause of mortality in the world. Medicinal plants are a part of complementary and alternative medicine, which have wide use in the treatment of diabetes. Besides, combination therapy as an effective therapeutic strategy is highly recommended for controlling hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan Rheum Ribes L. and Urtica Dioica L. extracts either alone or in combination on blood glucose level in type 2 diabetic rats. Diabetes was induced by single-dose administration of Streptozotocin (50 mg/kg) in rats. Diabetic rats were received intraperitoneal administration of R. Ribes aqueous extract (40 and 60 mg/kg), U. Dioica aqueous-alcoholic extract (100 and 200 mg/kg), and their combination for 21 days. The fasting blood glucose and body weight of rats were determined on 0, 7 th , 14 th , and 21 st days. The results showed that R. Ribes extract (40 and 60 mg/kg), U. Dioica extract (200 mg/kg), and their combination could significantly decrease the blood glucose level on 0, 7 th , 14 th , and 21 st days (P<0.0001). Only 200 mg/kg of U. Dioica had a positive effect on the bodyweight loss of diabetic rats (P<0.01). It can be concluded that Afghan R. Ribes and U. Dioica extracts and their combination have a hypoglycemic effect. However, their combinations do not show any synergic or antagonistic effects.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Hussaini¹,

Askndari²,

Alami³

et al. 2021

Int j pharm phytopharm res

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“…GLP-1 is known to stimulate glucose-stimulated insulin secretion and β-cell mass in diabetic partially pancreatectomized rats [ 47 ]. Furthermore, blackcurrant extract intake (0.3 g/day human equivalents) reduces malondialdehyde contents by increasing antioxidant enzymes, such as superoxide dismutase, catalase, and glutathione peroxidase, indicating a reduction of oxidative stress [ 48 ]. We also demonstrated that TNF-α expression and MDA contents in islets were higher in the control group than in the positive-C group and that BC administration decreased them to the same levels as the positive-C group.…”

Section: Discussionmentioning

confidence: 99%

Aqueous Blackcurrant Extract Improves Insulin Sensitivity and Secretion and Modulates the Gut Microbiome in Non-Obese Type 2 Diabetic Rats

Yang

Zhang

et al. 2021

Antioxidants

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This study was undertaken to determine whether aqueous blackcurrant extracts (BC) improve glucose metabolism and gut microbiomes in non-obese type 2 diabetic animals fed a high-fat diet and to identify the mechanism involved. Partially pancreatectomized male Sprague–Dawley rats were provided a high-fat diet containing 0% (control), 0.2% (L-BC; low dosage), 0.6% (M-BC; medium dosage), and 1.8% (H-BC; high dosage) blackcurrant extracts; 0.2% metformin (positive-C); plus 1.8%, 1.6%, 1.2%, 0%, and 1.6% dextrin, specifically indigestible dextrin, daily for 8 weeks. Daily blackcurrant extract intakes were equivalent to 100, 300, and 900 mg/kg body weight (bw). After a 2 g glucose or maltose/kg bw challenge, serum glucose and insulin concentrations during peak and final states were obviously lower in the M-BC and H-BC groups than in the control group (p < 0.05). Intraperitoneal insulin tolerance testing showed that M-BC and H-BC improved insulin resistance. Hepatic triglyceride deposition, TNF-α expression, and malondialdehyde contents were lower in the M-BC and H-BC groups than in the control group. Improvements in insulin resistance in the M-BC and H-BC groups were associated with reduced inflammation and oxidative stress (p < 0.05). Hyperglycemic clamp testing showed that insulin secretion capacity increased in the acute phase (2 to 10 min) in the M-BC and H-BC groups and that insulin sensitivity in the hyperglycemic state was greater in these groups than in the control group (p < 0.05). Pancreatic β-cell mass was greater in the M-BC, H-BC, and positive-C groups than in the control group. Furthermore, β-cell proliferation appeared to be elevated and apoptosis was suppressed in these three groups (p < 0.05). Serum propionate and butyrate concentrations were higher in the M-BC and H-BC groups than in the control group. BC dose-dependently increased α-diversity of the gut microbiota and predicted the enhancement of oxidative phosphorylation-related microbiome genes and downregulation of carbohydrate digestion and absorption-related genes, as determined by PICRUSt2 analysis. In conclusion, BC enhanced insulin sensitivity and glucose-stimulated insulin secretion, which improved glucose homeostasis, and these improvements were associated with an incremental increase of the α-diversity of gut microbiota and suppressed inflammation and oxidative stress.

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“…Preliminary studies on P. hydropiper L. ethanolic extract revealed antidiabetic potentials in oral glucose tolerance test [ 16 ]. Polygonum senegalensis , Muehlenbeckia tamnifolia (Kunth) Meisn, Rheum ribes L., Polygonum glabrum , and other species are validated for antidiabetic potentials [ 17 – 20 ]. Our previous findings suggest that P. hydropiper exhibit neuroprotective, gstroprotective, cytotoxic, and antimicrobial properties [ 21 – 29 ].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Enzyme Inhibitory, and Molecular Docking Approaches to the Antidiabetic Potentials of Bioactive Compounds from Persicaria hydropiper L.

Ayaz

Sadiq

Mosa

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Introduction. Natural products are among the most useful sources for the discovery of new drugs against various diseases. Keeping in view the ethnobotanical relevance ethnopharmacological significance of Polygonaceae family in diabetes, the current study was designed to isolate pure compounds from Persicaria hydropiper L. leaves and evaluate their in vitro and in silico antidiabetic potentials. Methods. Six compounds were isolated from the chloroform-ethyl acetate fractions using gravity column chromatography and were subjected to structure elucidation process. Structures were confirmed using 1H-NMR, 13C-NMR, and mass spectrometry techniques. Isolated phytochemicals were subjected to in vitro antidiabetic studies, including α-glucosidase, α-amylase inhibition, and DPPH, and ABTS antioxidant studies. Furthermore, the in silico binding mode of these compounds in the target enzymes was elucidated via MOE-Dock software. Results. The isolated compounds revealed concentration-dependent inhibitions against α-glucosidase enzyme. Ph-1 and Ph-2 were most potent with 81.84 and 78.79% enzyme inhibitions at 1000 µg·mL−1, respectively. Ph-1 and Ph-2 exhibited IC50s of 85 and 170 µg·mL−1 correspondingly. Likewise, test compounds showed considerable α-amylase inhibitions with Ph-1 and Ph-2 being the most potent. Tested compounds exhibited considerable antioxidant potentials in both DPPH and ABTS assays. Molecular simulation studies also revealed top-ranked confirmations for the majority of the compounds in the target enzymes. Highest observed potent compound was Ph-1 with docking score of −12.4286 and formed eight hydrogen bonds and three H-pi linkages with the Asp 68, Phe 157, Phe 177, Asn 241, Glu 276, His 279, Phe 300, Glu 304, Ser 308, Pro 309, Phe 310, Asp 349, and Arg 439 residues of α-glucosidase binding packets. Asp 68, Glu 276, Asp 349, and Arg 439 formed polar bonds with the 3-ethyl-2-methylpentane moiety of the ligand. Conclusions. The isolated compounds exhibited considerable antioxidant and inhibitory potentials against vital enzymes implicated in T2DM. The docking scores of the compounds revealed that they exhibit affinity for binding with target ligands. The enzyme inhibition and antioxidant potential of the compounds might contribute to the hypoglycemic effects of the plant and need further studies.

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The effect of Rheum ribes L. on oxidative stress in diabetic rats

Cited by 14 publications

References 24 publications

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Effect of Rheum Ribes and Urtica Dioica on type 2 diabetic rats

Aqueous Blackcurrant Extract Improves Insulin Sensitivity and Secretion and Modulates the Gut Microbiome in Non-Obese Type 2 Diabetic Rats

Antioxidant, Enzyme Inhibitory, and Molecular Docking Approaches to the Antidiabetic Potentials of Bioactive Compounds from Persicaria hydropiper L.

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