The Effect ofMorinda citrifoliaL. Fruit Juice on the Blood Sugar Level and Other Serum Parameters in Patients with Diabetes Type 2

Abstract

Background The effect of the daily consumption of Morinda citrifolia (Noni) fruit juice on the physiological status of patients with diabetes type 2 (DT2) was tested over a period of two months. Methods Morinda citrifolia (Noni) fruit juice (NFJ), 2 ml per kg bw per day, was consumed by twenty patients with DT2 after they underwent a standard treatment regimen including carbohydrate reduced diet and treatment with an antidiabetic drug and/or insulin. NFJ consumption started only after no further improvement was achieved. The intake of NFJ was terminated after eight weeks. The fasting blood sugar level was monitored every morning during the entire treatment period. Blood samples were taken before, at, and four and eight weeks after the start of NFJ intake. The analysis of the blood samples included the concentration of blood glucose, HbA1c, C-peptide, hs-CRP, triglycerides, total cholesterol, LDL, and HDL. Results The consumption of NFJ by 20 patients with DT2 resulted in a significant mean decrease of the morning blood sugar level monitored over a period of eight weeks. While NFJ reduced the blood glucose level in several but not all hyperglycemic patients, it did not cause hypoglycemia in normoglycemic patients. NFJ consumption also reduced the mean HbA1c value significantly (p= 0.033). Significant decreases (p= 0.01) were also achieved for high sensitive CRP values in patients starting with high levels (>2 mg/L), whereas no change was observed in patients with normal values (< 2 mg/L). The level of C-peptide showed a significant mean increase after four weeks of NFJ consumption in those patients who started with low levels (<3 μg/l, p=0.004, N=11) but not in patients with higher levels (> 3 μg/L). Conclusion The daily consumption of NFJ has the potential to regulate elevated blood sugar levels and some other pathological parameters in patients with DT2. NFJ therefore serves as a suitable additive to the diet of diabetic patients.

Effects of Acute Consumption of Noni and Chokeberry Juices vs. Energy Drinks on Blood Pressure, Heart Rate, and Blood Glucose in Young Adults

“…Considering noni juice, three portions (each at 30 mL) caused a decrease of the final blood glucose by 7.3%, whereas consumption of three portions of chokeberry juice or water led to a decrease in BG by 1.5% and 4.8%, respectively. In another clinical trial, including 20 people, consumption of noni fruit juice in a dose of 2 mL per kg of body weight for 8 weeks resulted in a significant decrease in BG [34].…”

Properties and Applications of Morinda citrifolia (Noni): A Review

“…Lastly, a clinical test on the effect of daily consumption of NFJ on the physiological stage of 20 patients with type 2 diabetes for 8 weeks with analysis of blood sugar levels was evaluated by Algenstaedt, Stumpenhagen, and Westendorf (). The analysis of the blood samples included the concentration of blood glucose, HbA1c, C‐peptide, hs‐CRP, triglycerides, and total cholesterol.…”

Ethnomedicinal survey of traditional antidiabetic plants in Baturraden and Sumbang

“…57 Furthermore, the juice of Morinda citrifolia fruits significantly reduced the morning blood glucose and HbA1c levels in patients with type 2 diabetes mellitus. 58 Traditional use of Muntingia calabura for diabetic medication is reported in Subulussalam, Karawang (West Java), and Bau-bau (Southeast Sulawesi). 9,59,60 The previous study demonstrated that the stem bark extract of this plant was useful for lowering the uric acid level and maintaining the healthy structure of renal proximal tubular cells in diabetic rats.…”