The effect of <i>Helicobacter pylori</i> eradication therapy on gastric antral myoelectrical activity and gastric emptying in patients with non‐ulcer dyspepsia

Miyaji,; Azuma,; Abé,; Ono,; Suto,; Yamazaki,; Kohli,; Kuriyama,

doi:10.1046/j.1365-2036.1999.00621.x

Cited by 39 publications

(50 citation statements)

References 26 publications

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“…The gastric emptying is a functional marker, while myoelectrical activity is an electrophysiological marker for the evaluation of gastric motility. Therefore, such a discrepancy could occur in our previous study (11).…”

Section: Gastric Myoelectrical Activity and Gastric Emptyingmentioning

confidence: 56%

“…Myoelectrical activities of 2-4 cycles per min were defined as the normal range. Pre-and post-prandial myoelectrical activity showing over 70% of the normal range was defined as a normal EGG as described in our previous reports (11,12). The rate of gastric emptying was determined by measuring the plasma concentrations of paracetamol 45 minutes after oral intake of 1.5 g paracetamol with a 200 ml semi-liquid meal (OKUNOS-A, Horikawa Foods, Niigata, Japan) as described in our previous reports (11,12 …”

Section: Gastric Myoelectrical Activity and Gastric Emptyingmentioning

confidence: 99%

“…Gastric myoelectrical activity and gastric emptying have been widely applied to the evaluation of gastric motility in patients with various gastrointestinal disorders (9)(10)(11)(12). In the present study, we analyzed the accumulation of mitochondrial A3243G mutation in the stomach, gastric motility by myoelectrical activity and gastric emptying in patients with gastric symptoms, post-prandial nausea/vomiting and epigastralgia, and the mutation in their leukocytes.…”

Section: Introductionmentioning

confidence: 97%

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Gastric Dysmotility Associated with Accumulation of Mitochondrial A3243G Mutation in the Stomach

et al. 2004

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Objective We analyzed the accumulation of a mitochondrial A-to-G mutation at nucleotide position 3243 (A3243G) in the stomach and gastric motility in patients with gastric symptoms, post-prandial nausea/vomiting and epigastralgia.Methods Detection and quantification of A3243G mutation in mtDNA in the gastric mucosa, oral mucosa, leukocyte, and skeletal muscle were performed. Gastric motility was evaluated by gastric myoelectrical activity on electrogastrography (EGG), and gastric emptying was evaluated by measurement of plasma paracetamol concentration before and after meals.Patients or Materials Four patients with A3243G mutation in the leukocyte mtDNA and gastric symptoms were examined.Results The A3243G mutation was detected at higher percentages in the gastric body (69-94% for mutation; mean, 83%) than in the angle portion (37-82%; mean, 52%), the antrum (40-84%; mean, 57%) or leukocytes (28-52%; mean, 39%), and at slightly higher percentages than in the skeletal muscles (45-87%; mean, 70%) or oral mucosae (52-86%; mean, 69%) in the four patients examined. Abnormal EGGs were observed in the three patients examined. The pre-prandial myoelectrical activities were low in these patients (49% in patient 1, 54% in patient 2, 63% in patient 3; normal >70%). The plasma concentrations of paracetamol were low (3.6 g/ml in patient 1, 2.4 g/ml in patient 2, <2.0 g/ml in patient 3; normal, 7-12 g/ml).Conclusion Accumulation of mitochondrial A3243G mutation in the stomach is a contributory factor in gastric dysmotility and gastric symptoms in patients with the mutation in their leukocytes.

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Section: Gastric Myoelectrical Activity and Gastric Emptyingmentioning

confidence: 56%

Section: Gastric Myoelectrical Activity and Gastric Emptyingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

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Gastric Dysmotility Associated with Accumulation of Mitochondrial A3243G Mutation in the Stomach

et al. 2004

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“…Kachi et al [8], as well as Miyaji et al [23], reported that GE was improved by H. pylori eradication in patients with initially disturbed gastric evacuation. On the other hand, Koskenpato et al did not observe statistically significant differences in GE between H. pylori-eradicated and placebo-treated patients after 1 year [21].…”

Section: Discussionmentioning

confidence: 99%

Effect of Helicobacter pylori eradication on gastric emptying and symptoms in patients with dyspepsia

Waluga¹,

Jonderko²,

Krusiec-Świdergoł³

et al. 2011

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Aim: To study whether eradication of Helicobacter pylori (H. pylori) in patients with functional dyspepsia affects gastric emptying (GE) and concomitantly relieves their clinical symptoms. Material and methods: Eighteen H. pylori-positive patients suffering from functional dyspepsia were recruited. At entrance and two weeks after successful H. pylori eradication they filled in a questionnaire examining the intensity of dyspeptic symptoms and underwent measurement of GE of a 378 kcal solid test meal labelled with 75 μl of 13 C-octanoic acid. Normative values of GE were obtained in 12 healthy controls. Results: Helicobacter pylori eradication was attained in 17 patients. The duration of the lag phase (T_Lag) of the GE did not change after the eradication (mean ± SD 144.5 ±23.2 min) vs. before the eradication (152.1 ±27.6 min). On the other hand, the gastric half emptying time (T 1/2 ) increased statistically significantly from 207.1 ±33.5 min before eradication to 229.5 ±49.4 min (p = 0.0217). Considering the whole patient group, the H. pylori eradication did not significantly affect the dyspeptic symptoms. It was established, however, that the deterioration of the score for fullness or satiety was dependent on the increase in the T_Lag. Also the aggravation of pain, burning or satiety was related to the prolongation of the T 1/2 . Conclusions: 1) Eradication of H. pylori in patients with functional dyspepsia prolongs the gastric half emptying time of a solid meal without eliciting a significant symptomatic improvement.2) The worsening of dyspeptic symptoms may be related to sluggish gastric emptying. StreszczenieCel: Ustalenie, czy eradykacja Helicobacter pylori (H. pylori) u chorych z dyspepsją czynnościową wpływa na szybkość opróżniania żołądka (gastric emptying -GE) i złagodzenie towarzyszących objawów klinicznych. Materiał i metody: W badaniu wzięło udział 18 chorych z infekcją H. pylori cierpiących na dyspepsję czynnościową. W czasie włączania do badania oraz 2 tyg. po skutecznej eradykacji wypełniali oni kwestionariusz mający na celu określe-nie nasilenia objawów dyspeptycznych oraz zostali poddani pomiarowi GE z posiłku stałego o wartości energetycznej 378 kcal z dodatkiem 75 μl 13 C-kwasu oktanowego. Wartości normatywne kinetyki GE wyznaczono u 12 zdrowych osób. Wyniki: Eradykację H. pylori uzyskano u 17 chorych. Czas trwania fazy opóźnienia GE (T_Lag) nie zmienił się po eradykacji (średnia ± SD 144,5 ±23,2 min) w porównaniu z czasem przed eradykacją (152,1 ±27,6 min). Półokres GE (T 1/2 ) natomiast zwię kszył się statystycznie znamiennie z 207,1 ±33,5 min przed eradykacją do 229,5 ±49,4 min po eradykacji (p = 0,0217). Biorąc pod uwagę całą grupę chorych, eradykacja H. pylori nie wpłynęła znamiennie na objawy dyspeptyczne. Wykazano jednak, że pogorszenie punktacji w skali oceny uczucia pełności lub wczesnej sytości zależało od wzrostu długości T_Lag, podczas gdy zwiększenie odczucia bólu, pieczenia i pełności od wydłużenia T 1/2 . Wnioski: 1) Eradykacja H. pylori u chorych z dyspepsją czynnościową...

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“…Miyaji et al analysed the gastric emptying in patients with non-ulcer dyspepsia and reported that the gastric emptying was normalized significantly by the eradication therapy in the delayed and rapid gastric emptying groups, but unchanged in the normal gastric emptying groups. 18 Saslow et al found that H. pylori infection and gastritis resulted in reduced accommodation (diastolic dysfunction) but no change in gastric emptying of solids in asymptomatic volunteers. 19 13 C-acetate breath test is proposed to be a reliable, non-invasive test to measure gastric emptying rates of liquid test meals.…”

Section: Discussionmentioning

confidence: 99%

¹³C‐ethanol breath test reveals impaired alcohol metabolism in patients with Helicobacter pylori infection

Suzuki

Maruyama

Suzuki

et al. 2004

Aliment Pharmacol Ther

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SUMMARY Background:The gastric mucosal alcohol dehydrogenase activity was reported to be reduced in subjects with Helicobacter pylori-associated chronic gastritis. However, the role of H. pylori infection in the metabolism of ingested ethanol has not been fully elucidated. Aim: To clarify whether H. pylori infection exerts any influence on the metabolism of small amounts of ethanol in humans. Subjects and methods: 13 C-ethanol (100 lL) diluted in

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The effect of Helicobacter pylori eradication therapy on gastric antral myoelectrical activity and gastric emptying in patients with non‐ulcer dyspepsia

Cited by 39 publications

References 26 publications

Gastric Dysmotility Associated with Accumulation of Mitochondrial A3243G Mutation in the Stomach

Gastric Dysmotility Associated with Accumulation of Mitochondrial A3243G Mutation in the Stomach

Effect of Helicobacter pylori eradication on gastric emptying and symptoms in patients with dyspepsia

¹³C‐ethanol breath test reveals impaired alcohol metabolism in patients with Helicobacter pylori infection

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The effect of Helicobacter pylori eradication therapy on gastric antral myoelectrical activity and gastric emptying in patients with non‐ulcer dyspepsia

Cited by 39 publications

References 26 publications

Gastric Dysmotility Associated with Accumulation of Mitochondrial A3243G Mutation in the Stomach

Gastric Dysmotility Associated with Accumulation of Mitochondrial A3243G Mutation in the Stomach

Effect of Helicobacter pylori eradication on gastric emptying and symptoms in patients with dyspepsia

13C‐ethanol breath test reveals impaired alcohol metabolism in patients with Helicobacter pylori infection

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¹³C‐ethanol breath test reveals impaired alcohol metabolism in patients with Helicobacter pylori infection