The Effect ofCeratonia siliquaSupplement on Bone Mineral Density in Ovariectomy-induced Osteoporosis in Rats

Abstract

Aim: This study aimed to investigate the effect of Ceratonia siliqua on bone mineral density (BMD) as a nonpharmaceutical alternative treatment for postmenopausal osteoporosis. Materials and Methods: Thirty mature female Wistar rats were randomly separated into three groups of 10: Control, ovariectomized (OVX), and ovariectomized-plus-C. siliqua (OVX+CS). Total and proximal BMD were measured by dual-energy X-ray absorptiometry (DEXA) in all groups before ovariectomy, and at 3 and 6 months postoperatively.At the end of the study, the femurs were subjected to a threepoint bending test. Results: DEXA revealed no statistically significant difference in absolute values or percentage changes for total tibial BMD between OVX+CS and OVX groups throughout the study. In the proximal tibia, both absolute values and BMD percentage changes from baseline were higher in the OVX+CS group compared to the OVX group after 3 and 6 months of C. siliqua administration. Three-point bending test revealed a significantly higher thickness index in the OVX+CS group compared to the OVX group and a higher cross-sectional area index compared to the control group. Conclusion: Long-term administration of C. siliqua may be considered a non-pharmaceutical alternative treatment for postmenopausal osteoporosis. Further research is required to properly investigate the effects, and suitable treatment dose and schedule.Osteoporosis is a multifactorial skeletal disorder that is a public health concern and a heavy economic burden (1-3). After 35-40 years of age, osteoclasts are more active than osteoblasts. As a result, bone mass is lost, which occurs faster in postmenopausal women depending on lifestyle, diet, and other factors, because of their decreasing sex hormones 270

International Biological Flora: Ceratonia siliqua

“…Carob has also proved useful in animal husbandry since it acts a diuretic (El-Haskoury et al, 2015), gives protection against diabetes and liver damage in rats and is used in treating osteoporosis, inducing puberty in rats (Khader et al, 2023;Neri et al, 2023;Rtibi et al, 2017;Uğurlu et al, 2023) and protecting the liver in mice from paracetamol-induced injury (Martić et al, 2022). Carob syrup can also boost the immune system of the Nile tilapia fish Oreochromis niloticus (L.) and improve their resistance to ammonia (Yilmaz, 2020).…”