The effect of Abelmoschus esculentus L. (Okra) extract supplementation on dietary intake, appetite, anthropometric measures, and body composition in patients with diabetic nephropathy

Abstract

Background: Diabetes is a risk factor for chronic kidney disease because it induces nephropathy. Okra is a rich source of antioxidants, vitamins, minerals, and fibers, of which favorable effects in diabetes have been reported in many animal studies. The present trial aimed to investigate the effect of dried okra extract (DOE) supplementation on anthropometric measures, body composition, appetite, and dietary intake in diabetic nephropathy (DN) patients. Methods: In this triple-blind placebo-controlled randomized clinical trial, 64 DN patients were randomly allocated to receive a 125-mg capsule of DOE (n=32) or placebo (n=32) for 10 weeks. At baseline and endpoint of the trial, anthropometric variables, body composition indices, dietary intake, and appetite scores were evaluated. Results: The results showed that energy (P=0.047, CI: -425.87, -3.25, ES: 0.539) and carbohydrate (P=0.038, CI: -85.64, -2.53, ES: 0.555) intake as well as desire to eat salty food (P=0.023) were reduced in DOE group at the endpoint, compared to the baseline values. However, anthropometric measures, body composition, and appetite score were not significantly different between the two study groups. Conclusion: In conclusion, the present clinical trial showed that DOE could significantly decrease energy intake and carbohydrate consumption in the DN patients. Further clinical trials are needed to determine the effects of this supplement.

The impacts of okra consumption on the nutritional status of pregnant women, west Ethiopia

“…In line with this, animal experiments indicated that okra suppresses insulin resistance, thereby improving the blood glucose level of gestational diabetic mellitus (Tian et al, 2015). Moreover, clinical trials indicated that supplementation of dried okra extract could significantly decrease energy intake and carbohydrate consumption in diabetic nephropathy patients (Nikpayam et al, 2022).…”

“…In line with this, animal experiments indicated that okra suppresses insulin resistance, thereby improving the blood glucose level of gestational diabetic mellitus (Tian et al, 2015 ). Moreover, clinical trials indicated that supplementation of dried okra extract could significantly decrease energy intake and carbohydrate consumption in diabetic nephropathy patients (Nikpayam et al, 2022 ). For this reason, okra is considered to be an economically affordable vegetable crop with various potential health benefits and improves the nutritional status of pregnant women (Elkhalifa et al, 2021 ).…”

Okra (Abelmoschus esculentus) Intake Improves Lipid Profile and Liver Transaminases in Pre-diabetic Adults: A Randomized Double-blinded Trial

“…In another study, Moradi et al reported that 8 weeks of okra consumption led to a substantial reduction in serum TC, FPG, TG, homeostasis model assessment of insulin resistance (HOMA-IR), and LDL-C levels (24). Also, in a clinical trial on diabetic nephropathy patients, Nikpayam et al found a significant reduction in energy intake and carbohydrate consumption after 10 weeks of okra supplementation (25). The effectiveness of okra in FPG and TC in individuals with T2DM was also reported by Haryati and Rahmawati in 2019 (26).…”