2021
DOI: 10.3389/fbioe.2021.711977
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The Effect of Hypoxic and Normoxic Culturing Conditions in Different Breast Cancer 3D Model Systems

Abstract: The field of 3D cell cultures is currently emerging, and material development is essential in striving toward mimicking the microenvironment of a native tissue. By using the response of reporter cells to a 3D environment, a comparison between materials can be assessed, allowing optimization of material composition and microenvironment. Of particular interest, the response can be different in a normoxic and hypoxic culturing conditions, which in turn may alter the conclusion regarding a successful recreation of… Show more

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Cited by 3 publications
(2 citation statements)
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“…Three-dimensional printing and bioprinting are other strategies to produce 3D scaffolds as they have the advantage of tuning the shape and properties of the scaffold as well as incorporating cells within the structure when mixed with the ink before printing. Three-dimensional printed scaffolds can mimic human tumor tissue more closely compared with 2D cell cultures [ 24 , 25 , 26 ].…”
Section: 3d Cancer Tissue Modelsmentioning
confidence: 99%
“…Three-dimensional printing and bioprinting are other strategies to produce 3D scaffolds as they have the advantage of tuning the shape and properties of the scaffold as well as incorporating cells within the structure when mixed with the ink before printing. Three-dimensional printed scaffolds can mimic human tumor tissue more closely compared with 2D cell cultures [ 24 , 25 , 26 ].…”
Section: 3d Cancer Tissue Modelsmentioning
confidence: 99%
“…In conclusion, we have characterized an experimental approach, based on existing and easily available tools, that allows for controlled and precise application of high-frequency intermittent hypoxia both to 3D cell culture scaffolds such as ECM hydrogels as well as to precision-cut tissue slices. This approach, which is an advance on previous models investigating continuous hypoxia (Svanström et al, 2021), opens the door for the study of the specific noxious effects of intermittent hypoxia in the 3D-residing cells of the organs and tissues of patients with OSA under physiomimetic conditions. experimental support.…”
Section: Figurementioning
confidence: 99%