The effect of hypothermia on exocrine pancreatic secretion in rabbits

Dios, Isabel De; Arranz, A. Ojanguren; López, María Rodríguez

doi:10.1016/0300-9629(86)90708-5

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…The progressive fall in protein and enzyme output described in this study have been previously published [8,25]. Diversion of pancreatic juice from the intestine is reported to enhance pancreatic enzyme secretion [26][27][28] and the recirculation of pancreatic juice to significantly suppress pancreatic secretion in the rat [29].…”

Section: Discussionmentioning

confidence: 63%

Cimetidine increases the pancreatic response to histamine

et al. 1990

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The effects of histamine alone and histamine plus cimetidine on basal pancreatic exocrine secretion were determined in anaesthetized rabbits with an acute pancreatic cannula. Intravenous histamine administration (0.2-0.8 n mol/kg/min) increased pancreatic enzyme secretion. A much greater stimulative effect on pancreatic secretion was observed when histamine was administered against a constant background of H2 antagonist (cimetidine 4 mumol/kg/min). The results indicate that in the rabbit pancreas the stimulatory effect of histamine is mediated by H1 receptors.

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Section: Discussionmentioning

confidence: 63%

Cimetidine increases the pancreatic response to histamine

et al. 1990

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“…Early studies in anaesthetized animals showed it to possess a true spontaneous secretion (5), which could be augmented by vagal stimulation or intravenous acetylcholine (6). Between 1965 and the present, a number of studies have been published on anaesthetized rabbit, in which some aspects of pancreatic electrolyte secretion have been measured (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). In these studies, very considerable variations in the volume and composition of spontaneous and secretin-stimulated pancreatic juice are recorded, while in only four has the effect of CCK on fluid secretion been briefly mentioned (9,13, 16,18).…”

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confidence: 99%

Pancreatic Secretion by the Anaesthetized Rabbit in Response to Secretin, Cholecystokinin, and Carbachol

Seow

Case²,

Young³

1991

Pancreas

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Considerable differences exist among species in the patterns of regulation of pancreatic secretion. Although rabbit pancreas is quite often used for in vivo and in vitro studies of pancreatic function, responses of this gland in vivo to common pancreatic stimuli have never been characterised in detail.That was the purpose of this study. The data demonstrate the existence of a spontaneous fluid secretion that can be increased by intravenous infusions of secretion (sevenfold), cholecystokinin-octapeptide (CCK8) (threefold), and carbachol (sixfold). The electrolyte composition of the secretion evoked by each of these stimuli was similar: sodium and potassium concentrations were constant and slightly higher than those in plasma at all secretory rates, whereas bicarbonate concentration rose with secretory rate to approach a plateau of about 125 mmol/L, and chloride concentration fell to a plateau of about 35 mmol/L. In terms of protein secretion, secretin caused a small but significant rise in output, while CCK8 and carbachol evoked the expected large increase. Thus, regulation of pancreatic electrolyte secretion in rabbit differs from that in dog, cat, and human, on the one hand, and rat, on the other hand, and most closely resembles the pattern observed in guinea pig.

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Histamine receptors in unstimulated pancreatic exocrine secretion of the rabbit

1989

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Histamine H2-receptor antagonists cimetidine and oxmetidine, H2-receptor agonist dimaprit, H1-receptor antagonist chlorpheniramine and H1-receptor agonist 2-thiazolylethylamine were tested for their effects on unstimulated pancreatic exocrine secretion in anaesthetized rabbits fitted with an acute pancreatic cannula. Intravenous administration of H1 agonist induces a dose-dependent increase in pancreatic secretion but H1 antagonist have the opposite effects. Intravenous administration of H2 antagonists induces effects similar the ones produced after H1 agonist infusion. The implications of H1 and H2 receptors on exocrine pancreatic secretion are discussed.

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The effect of hypothermia on exocrine pancreatic secretion in rabbits

Cited by 5 publications

References 18 publications

Cimetidine increases the pancreatic response to histamine

Cimetidine increases the pancreatic response to histamine

Pancreatic Secretion by the Anaesthetized Rabbit in Response to Secretin, Cholecystokinin, and Carbachol

Histamine receptors in unstimulated pancreatic exocrine secretion of the rabbit

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