The effect of hypochlorous acid on the filtration performance and bacterial decontamination of N95 filtering facemask respirators

Brooks, J. Patrick; Lupfer, Christopher R.; Hao, Weixing; Kapiamba, Kashala Fabrice

doi:10.1016/j.ajic.2022.07.013

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Once the microorganisms were trapped in the fi lter, approximately 1% of the inoculated bacteria were recovered in the buff er solution, and the exact decontamination capacity of each method was unclear. However, other in-vitro studies have demonstrated that many methods tested in this study have effi cient decontamination capacity against viruses and bacteria, including M. tuberculosis [12,[17][18][19]. However, the microorganism trapping capacity of the N95 respirator is high and may not release the captured microorganisms from the fi bre fi ltration system.…”

Section: Discussionmentioning

confidence: 84%

Comparative Evaluation of Microorganism Disinfection Methods for N95 Respirators

Mitarai*,

Noda,

Gondaira

et al. 2024

J Biomed Res Environ Sci

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Background: An excessive demand for N95 respirators occurred during the SARS-CoV-2 pandemic. Therefore, health care workers were obligated to reuse N95 respirators, which were intended to be disposable. Aim: The primary objective of this study was to establish a standard procedure for safe disinfection or sterilization that does not affect the performance of an N95 respirator. Methods: As disinfection or sterilization methods, immersion in 70% ethanol, 0.1% hypochlorous acid, 0.3% peracetic acid, 0.2% alkyldiaminoethylglycine hydrochloride aqueous solution, hypochlorous acid water, or plant mineral-activated water, autoclaving, pasteurization and hydrogen peroxide plasma sterilization were used. After sterilization/disinfection, the filtration capacity of each N95 respirator was examined. Findings: The performance changes in the N95 respirator caused by each sterilization/disinfection method differed for each manufacturer’s product. Seventy percent ethanol, 0.1% sodium hypochlorite aqueous solution, 0.3% peracetic acid aqueous solution, autoclaving, hypochlorous acid water, and plant mineral-activated water significantly deteriorated the performance of N95 respirators. Performance degradation (increased permeability) was observed in 0.2% alkyldiaminoethylglycine hydrochloride aqueous solution and hydrogen peroxide plasma sterilization, and the permeation performance significantly deteriorated by 50–70% in all N95 respirators tested. Only pasteurization resulted in no deterioration in performance, even after five repeated sterilizations. Conclusion: Verification of sterilization/disinfection methods for the reuse of N95 respirators has shown that the currently recommended hydrogen peroxide plasma sterilization is inadequate as it increases permeability by more than 50% with a single treatment. In this study, pasteurization was found to be the optimal sterilization method.

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Section: Discussionmentioning

confidence: 84%

Comparative Evaluation of Microorganism Disinfection Methods for N95 Respirators

Mitarai*,

Noda,

Gondaira

et al. 2024

J Biomed Res Environ Sci

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“…Similar to one of hypochlorites, HOCl disinfectant is increasingly used in heavily contaminated hospital environments and for wound treatment and patient decolonization at low concentrations, 38 , 39 but concentration-dependent effect of HOCl on the cytotoxicity and antibacterial activity remain to be studied for further clinical application. This knowledge of biological properties of HOCl may allow us to formulate antiseptic agents that provide desired biological response.…”

Section: Discussionmentioning

confidence: 99%

In vitro cytotoxicity and antibacterial activity of hypochlorous acid antimicrobial agent

Tsai

Chung

Ding

et al. 2023

Journal of Dental Sciences

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Reaction-induced headspace strategy toward efficient available chlorine analysis in bleaching water products

Xie,

Gan,

Gong

2024

Microchemical Journal

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The effect of hypochlorous acid on the filtration performance and bacterial decontamination of N95 filtering facemask respirators

Cited by 3 publications

References 21 publications

Comparative Evaluation of Microorganism Disinfection Methods for N95 Respirators

Comparative Evaluation of Microorganism Disinfection Methods for N95 Respirators

In vitro cytotoxicity and antibacterial activity of hypochlorous acid antimicrobial agent

Reaction-induced headspace strategy toward efficient available chlorine analysis in bleaching water products

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