The Effect of Hyperchylomicronaemia on Oxygen Affinity in Human Blood

Poss, M. J.; Longmuir, I. S.

doi:10.1007/978-1-4684-5643-1_46

Cited by 1 publication

(1 citation statement)

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“…A marked left shift of the ODC has been demonstrated in familial type 1 hyperlipoproteinemia (familial combined hyperlipidemia), in diabetic and nondiabetic persons with hyperlipoproteinemia type V (mixed hypertriglyceridemia), and in blood mixed with lipid emulsions 31–33. The reason for this negative effect on tissue oxygen delivery might be an abolishment of the pH difference across the erythrocyte membrane resulting in a displacement of the ODC to the left by the Bohr effect 34…”

Section: Introductionmentioning

confidence: 99%

Lifestyle diseases and cardiovascular risk factors are interrelated to deficiencies of major substrates in ATP synthesis

Ditzel¹,

Lervang²

2010

VHRM

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Recent studies on diabetes and metabolic syndrome indicate a common disturbance of inorganic phosphate (Pi) metabolism. Pi is an important substrate in the formation of adenosine triphosphate (ATP), and many lifestyle diseases and cardiovascular risk factors similarly show deficiencies in either 1 or 2 major components of ATP synthesis. Age, male gender, hypertension, obesity, hypertriglyceridemia, metabolic syndrome, and diabetes mellitus are all associated with hypophosphatemia. In addition, tobacco smoking, hyperchylomicronemia, hypertension, and diabetes may involve defects in tissue oxygen delivery. Hypophosphatemia may lead to a critical decrease in intracellular Pi and to mitochondrial dysfunction, which might be counter-acted by the pharmacological use of fructose 1,6-diphosphate.

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Section: Introductionmentioning

confidence: 99%