The Effect of Hyperbaric Oxygen on Pulmonary Metastases in C3H Mice

Feder, Bernard H.; Stein, Joshua; Smith, Terence K.; Schaeflein, J. W.; Boutelle, J. L.; Conroy, Ruth

doi:10.1148/90.6.1181

Cited by 15 publications

(7 citation statements)

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“…19 Studies of animals suggest that hyperbaric oxygen does not stimulate latent tumor proliferation, although this remains a clinical concern. 20 Although sagittal anterior ITM constitutes a type of "conservation" procedure, such surgery is still radical and can impose severe functional deficits on the patient in terms of oral function. Excision of an adequate soft tissue margin around large tumors in the ventral tongue and floor of mouth that frequently penetrate the tongueroot muscles near the hyoid may require sacrifice of one or both hypoglossal nerves.…”

Section: Complicationsmentioning

confidence: 99%

Excision of Selected Intraoral Cancers by Use of Sagittal Inner Table Mandibulectomy

Collins

Saunders

1987

Otolaryngol.--head neck surg.

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The application of oral surgery osteotomy techniques, which are used in orthognathic surgery, to excision of squamous cell carcinomas in various oral cavity locations is described and illustrated in eight cases. These methods allow the full height of the inner table of the mandible to be removed as a margin for tumors which abut the lingual mucoperiosteum without radiologic evidence of bone erosion, while jaw continuity via the intact outer cortex is maintained. These techniques can also be used for marginal mandibulectomy and horizontal maxillectomy. Discussion includes criteria for selection of cases appropriate for such conservation surgery with respect to oncologic considerations, as well as complications encountered and their prevention.

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Section: Complicationsmentioning

confidence: 99%

Excision of Selected Intraoral Cancers by Use of Sagittal Inner Table Mandibulectomy

Collins

Saunders

1987

Otolaryngol.--head neck surg.

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“…In one study C3H mice with spontaneous mammary tumors showed a significant increase in pulmonary metastases when compared with controls 9 . Others have failed to demonstrate any such increase 11 …”

Section: Discussionmentioning

confidence: 97%

“…Others dispute these findings 7 . Further, some studies suggest an increased metastasis rate in patients irradiated in a hyperbaric field, 8 , 9 but others disagree with these conclusions 10–12 . An actual mechanism by which HBO influences tumor growth remains to be elucidated.…”

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confidence: 99%

Rapid Progression of Head and Neck Squamous Carcinoma after Hyperbaric Oxygenation

Martinez¹,

Bradfield

Kinsella

et al. 1996

Otolaryngol.--head neck surg.

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ILlMyperbaric oxygen (HBO) therapy is sometimes indicated in the course of treatment of head and neck cancer patients for the treatment of persistent infection 1 or bone or cartilage necrosis after radiation therapy 2-4 or as an adjunct to reconstructive proced~ares/ Recurrent or residual tumor may be present in patients undergoing HBO. Previous experimental studies have been inconclusive regarding the effect of HBO on tumor cells. Concerns have been raised regarding whether HBO leads to tumor activation. Some evidence suggests that HBO may have two independent effects on carcinogenesisinhibiting the development of new tumors while enhancing the growth of existing lesions. 6 Others dispute these findings. 7 Further, some studies suggest an increased metastasis rate in patients irradiated in a hyperbaric field, s,9 but others disagree with these conclusions.l°-12 An actual mechanism by which HBO influences tumor growth remains to be elucidated. CASE REPORTSCase ~!. A 30-year-old male tobacco chewer was treated for a T4N0 lateral tongue and tongue base lesion with wide excision, partial mandibulectomy, and right modified radical neck dissection. A radial forearm flap was used for

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“…In some series and studies, HBO has seemed to promote tumor growth, 1‐3 while other reports show no initiating or promoting effect 4‐7 . The same dichotomy exists for evidence on the effect of HBO on distant metastasis rate 2,6,8,9 . In a prior study at this institution, HBO was administered during the induction of chemical carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hyperbaric Oxygenation on Existing Oral Mucosal Carcinoma

et al. 1996

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Hyperbaric oxygen therapy (HBO) is used to treat some complications of head and neck carcinoma treatment. Several patients treated with HBO have had rapid growth of a clinically cured squamous cell carcinoma. Prior studies have produced conflicting evidence about the effect of HBO on tumor growth. This study was undertaken to determine the effects of HBO on established squamous cell carcinoma. Forty Golden Syrian hamster cheek-pouch carcinomas were induced with the established chemical carcinogen 9,10-dimethyl-1,2-benzanthracene. Twenty hamsters underwent 30 HBO dives for 60 minutes each to 2.81 atm, while 20 served as controls. At necropsy, animals receiving HBO therapy had significantly smaller tumors (P < .05) and showed a trend toward fewer cervical metastases (P < .06). HBO therapy with coexistent carcinoma inhibited the established tumor's growth.

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The Effect of Hyperbaric Oxygen on Pulmonary Metastases in C3H Mice

Cited by 15 publications

References 0 publications

Excision of Selected Intraoral Cancers by Use of Sagittal Inner Table Mandibulectomy

Excision of Selected Intraoral Cancers by Use of Sagittal Inner Table Mandibulectomy

Rapid Progression of Head and Neck Squamous Carcinoma after Hyperbaric Oxygenation

Effect of Hyperbaric Oxygenation on Existing Oral Mucosal Carcinoma

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