The effect of hydroxyapatite coating on ingrowth of bone into cavities in an implant

Stephenson, P.K.; Freeman, M. A. R.; Revell, Peter A.; Germain, J.; Tuke, M.; Pirie, C. J.

doi:10.1016/s0883-5403(06)80157-9

Cited by 137 publications

(70 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since then numerous reports have been published about the osteoconductive properties of CaP-coated implants (osteoconduction refers to the ability of a biomaterial to support the growth of bone over its surface). These CaP coatings are described to induce an increased bone-to-implant contact (38,(43)(44)(45), to improve the implant fixation (46), and to facilitate the bridging of small gaps between implant and surrounding bone (47,48). As an example of the osteoconductive properties of CaP coatings, Fig.…”

Section: Calcium Phosphate Coatingsmentioning

confidence: 99%

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

et al. 2008

View full text Add to dashboard Cite

Abstract. This paper reviews current physicochemical and biochemical coating techniques that are investigated to enhance bone regeneration at the interface of titanium implant materials. By applying coatings onto titanium surfaces that mimic the organic and inorganic components of living bone tissue, a physiological transition between the non-physiological titanium surface and surrounding bone tissue can be established. In this way, the coated titanium implants stimulate bone formation from the implant surface, thereby enhancing early and strong fixation of bone-substituting implants. As such, a continuous transition from bone tissue to implant surface is induced. This review presents an overview of various techniques that can be used to this end, and that are inspired by either inorganic (calcium phosphate) or organic (extracellular matrix components, growth factors, enzymes, etc.) components of natural bone tissue. The combination, however, of both organic and inorganic constituents is expected to result into truly bone-resembling coatings, and as such to a new generation of surface-modified titanium implants with improved functionality and biological efficacy.

show abstract

Section: Calcium Phosphate Coatingsmentioning

confidence: 99%

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

et al. 2008

View full text Add to dashboard Cite

show abstract

“…The performance of a bone graft substitute is greatly enhanced by the use of either an osteoconductive [23][24][25] or osteoinductive 26,27 material in which a response similar to the normal healing cascade of bone has been reported to occur within the porous structure. 11,18,28 Osteoconduction can be defined as the ability of a material to encourage bone to grow toward and along its surface, whereas osteoinductive materials possess the additional ability to trigger the spontaneous apposition of new bone directly on their surfaces via the differentiation of local stem cells into active boneforming cells.…”

Section: Introductionmentioning

confidence: 99%

Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes

Hing

Best

Tanner

et al. 2003

J Biomedical Materials Res

191

137

View full text Add to dashboard Cite

Abstract:Previous investigations have shown that both the early biological response and the mechanical properties of a porous hydroxyapatite bone graft substitute are highly sensitive to its pore structure. The objective of this study was to evaluate whether the pore structure continued to influence bone integration in the medium to long term. Two screened batches of porous hydroxyapatite (PHA) designated as batch A and batch B, with porosities of ϳ60 and 80%, respectively, were selected for this study and implanted for periods of 5, 13, and 26 weeks into the lower femur of New Zealand White rabbits. Histomorphometric analysis of the absolute volume of bone ingrowth within batch A and B implants from 5 to 26 weeks showed that the absolute volume of bone ingrowth was consistently lower in batch A (10 -21%), compared to batch B implants (24 -31%). However, when the volume of bone ingrowth was normalised for the available pore space, this difference was reduced (23-47% and 32-42% for batches A and B, respectively). These observations suggest that differences in the volume of bone ingrowth initially depended on pore interconnectivity rather than pore size, whereas the volume or morphology of the PHA influenced the volume and morphology of bone ingrowth at later time points. Compression testing showed that bone ingrowth had a strong reinforcing effect on PHA bone graft substitutes, and a strong correlation was identified between mechanical properties and the absolute volume of ingrowth for both batches A and B. Furthermore, at 13 and 26 weeks, there was no significant variation in the ultimate compressive strength of integrated batch A and B implants. This similarity in ultimate mechanical properties indicated that the absolute volume of ingrowth may be mediated by the PHA structure through its impact on the dynamics of the local biomechanical environment. The results of push-out testing showed that fixation of PHA bone graft substitutes was independent of density within the range studied, with no significant difference in the interfacial shear stress between batches A and B at each time point throughout the study.

show abstract

“…Early investigators stated that hydroxyapatite coatings permitted an implant fixation far superior to current methods using either cemented or cementless techniques. [10][11][12][13][14][15][16] However, controversial clinical results also were reported. Rothman et al, using a retrospective, matched-pair analysis, demonstrated that there appeared to be no clinical or radiographic advantage to the use of hydroxyapatite in primary total hip arthroplasties.…”

Section: Introductionmentioning

confidence: 99%

The influence of hydroxyapatite particles on osteoclast cell activities

Sun

Lin

Hung

et al. 1999

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

Aseptic loosening after total joint arthroplasty is a major problem in orthopedic surgery. Small particles from material wear have been reported as the main cause of implant failure. For this reason, investigation into possible wear particles from the materials used in the implant may lead to longevity after arthroplasty. Hydroxyapatite (HA) has been extensively investigated and reported as an excellent biomaterial with excellent biocompatibility. In this study, we used an in vitro osteoblast/osteoclast model to test the biocompatibility of various-sized HA particles. Primary osteoclasts/osteoblasts were co-cultured with different-sized HA particles (0.5-3.0 microm, 37-53 microm, 177-205 microm, and 420-841 microm) for 3 h, 1 day, 3 days, and 7 days. Cellular responses to the HA particles were evaluated by changes in cell counts and the secretion of transforming growth factor (TGF-beta1), alkaline phosphatase (ALP), tumor necrosis factor (TNF-alpha), prostaglandin (PGE2), and lactate dehydrogenase (LDH) in the supernatant of the culture media. The results showed that osteoblasts/osteoclasts co-cultured with HA particles smaller than 53 microm undergo the most significant changes. Cellular counts significantly decreased, and the changes were more obvious in the osteoblast population. There also was a significant decrease in TGF-beta1 concentration and a significant increase in PGE2 and LDH concentration, but there were no changes in the TNF-alpha or ALP titer. It can be concluded that larger HA particles may be quite compatible with bone cells while smaller-sized HA particles can both activate the osteoclasts and decrease the cell population of the osteoblasts. Justification for the additional expense incurred with the use of hydroxyapatite in primary total hip arthroplasty should be further evaluated.

show abstract

The effect of hydroxyapatite coating on ingrowth of bone into cavities in an implant

Cited by 137 publications

References 11 publications

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

Organic–Inorganic Surface Modifications for Titanium Implant Surfaces

Mediation of bone ingrowth in porous hydroxyapatite bone graft substitutes

The influence of hydroxyapatite particles on osteoclast cell activities

Contact Info

Product

Resources

About