The effect of hydrogen sulphide on experimental cerebral vasospasm

Emmez, Hakan; Börcek, Alp Özgün; Gönül, İpek Işık; Bolay, Hayrünnisa; Solaroğlu, İhsan; Baykaner, M. Kemali

doi:10.5137/1019-5149.jtn.16101-15.1

Cited by 5 publications

(7 citation statements)

References 23 publications

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“…H 2 S showed beneficial effects in a rat model of middle cerebral artery occlusion as hydrogen sulfide promoted angiogenesis, endothelial cell synthesis and migration, and also exerted neuroprotective effects after ischemia [57]. In a rat model of subarachnoid hemorrhage, NaHS lowered the vascular tone in cerebral vasospasm [3]. According to a study on rat pial arteries, after cerebral ischemia-reperfusion, the NO-mediated vasodilation is affected more severely than the H 2 S-induced mechanisms, therefore this latter pathway has important role under these circumstances [46].…”

Section: Examination Of the Linkage Between Serum Cysteine Levels And The Outcome Of Strokementioning

confidence: 99%

“…Patch-clamp techniques are also frequently used [54][55][56]. A peculiar approach, the surgically created cranial window allows repeated in vivo examinations in the same animal [49] while histological studies and stainings help to identify the characteristic enzyme type of a distinct tissue sample [3]. Regarding the concepts of the studies one possible and widely used option is to examine the effects at a higher H 2 S level than the endogenously produced amount.…”

Section: Experiments On the Involvement Of H 2 S In The Cerebrovascular Systemmentioning

confidence: 99%

“…Considering the method of H 2 S-administration several possible routes are used in experiments involving animals. In vivo studies are using many times intraperitoneal [3,57,58] administration or-in cerebrovascular studies-intraventricular injection [58] and even topical treatment through a previously prepared cranial window [46]. In human studies involving cerebrovascular questions, exogenous H 2 S treatment was not performed, only serum cysteine level was measured in a study including post-stroke patients [58].…”

Section: Experiments On the Involvement Of H 2 S In The Cerebrovascular Systemmentioning

confidence: 99%

“…The major effect of these diseases on the healthcare system and on the community is also underlined by the number of chronic disability cases that are caused by them [2]. Subarachnoideal bleeding is another severe condition where not only the bleeding itself but the consequential vasospasm constitutes a problem [3]. In addition to these life-threatening diseases a division of primary headaches (cluster headache, migraine) are also accompanied with vascular malfunction [4,5].…”

Section: Introductionmentioning

confidence: 99%

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The Potential Role of Hydrogen Sulfide in the Regulation of Cerebrovascular Tone

Dongó

Kiss

2020

Biomolecules

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A better understanding of the regulation of cerebrovascular circulation is of great importance because stroke and other cerebrovascular diseases represent a major concern in healthcare leading to millions of deaths yearly. The circulation of the central nervous system is regulated in a highly complex manner involving many local factors and hydrogen sulfide (H2S) is emerging as one such possible factor. Several lines of evidence support that H2S takes part in the regulation of vascular tone. Examinations using either exogenous treatment with H2S donor molecules or alterations to the enzymes that are endogenously producing this molecule revealed numerous important findings about its physiological and pathophysiological role. The great majority of these studies were performed on vessel segments derived from the systemic circulation but there are important observations made using cerebral vessels as well. The findings of these experimental works indicate that H2S is having a complex, pleiotropic effect on the vascular wall not only in the systemic circulation but in the cerebrovascular region as well. In this review, we summarize the most important experimental findings related to the potential role of H2S in the cerebral circulation.

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Section: Examination Of the Linkage Between Serum Cysteine Levels And The Outcome Of Strokementioning

confidence: 99%

Section: Experiments On the Involvement Of H 2 S In The Cerebrovascular Systemmentioning

confidence: 99%

Section: Experiments On the Involvement Of H 2 S In The Cerebrovascular Systemmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Potential Role of Hydrogen Sulfide in the Regulation of Cerebrovascular Tone

Dongó

Kiss

2020

Biomolecules

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“…In each animal, at least six random arterial cross-sections were qualitatively evaluated for the extent of internal lumen. The arterial cross-sections and intima-media thickness were measured with a computer-assisted image analysis system [ 35 , 36 , 79 , 80 , 81 , 82 ]. For each animal, the area of the BA was defined as the average area for six cross-sections of the BA.…”

Section: Methodsmentioning

confidence: 99%

Valproic Acid Reduces Vasospasm through Modulation of Akt Phosphorylation and Attenuates Neuronal Apoptosis in Subarachnoid Hemorrhage Rats

Tsai

et al. 2021

IJMS

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Aneurysmal subarachnoid hemorrhage (SAH) is a devastating emergent event associated with high mortality and morbidity. Survivors usually experience functional neurological sequelae caused by vasospasm-related delayed ischemia. In this study, male Sprague-Dawley rats were randomly assigned to five groups: sham (non-SAH) group, SAH group, and three groups with SAH treated with different doses of valproic acid (VPA) (10, 20, 40 mg/kg, once-daily, for 7 days). The severity of vasospasm was determined by the ratio of cross-sectional areas to intima-media thickness of the basilar arteries (BA) on the seventh day after SAH. The BA showed decreased expression of phospho-Akt proteins. The dentate gyrus showed increased expression of cleaved caspase-3 and Bax proteins and decreased expression of Bcl-2, phospho-ERK 1/2, phospho-Akt and acetyl-histone H3 proteins. The incidence of SAH-induced vasospasm was significantly lower in the SAH group treated with VPA 40 mg/kg (p < 0.001). Moreover, all groups treated with VPA showed reversal of the above-mentioned protein expression in BA and the dentate gyrus. Treatment with VPA upregulated histone H3 acetylation and conferred anti-vasospastic and neuro-protective effects by enhancing Akt and/or ERK phosphorylation. This study demonstrated that VPA could alleviate delayed cerebral vasospasm induced neuro-apoptosis after SAH.

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Role of hydrogen sulfide in subarachnoid hemorrhage

Wang

Liu

et al. 2022

CNS Neurosci Ther

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Subarachnoid hemorrhage (SAH) is a common acute and severe disease worldwide, which imposes a heavy burden on families and society. However, the current therapeutic strategies for SAH are unsatisfactory. Hydrogen sulfide (H2S), as the third gas signaling molecule after carbon monoxide and nitric oxide, has been widely studied recently. There is growing evidence that H2S has a promising future in the treatment of central nervous system diseases. In this review, we focus on the effects of H2S in experimental SAH and elucidate the underlying mechanisms. We demonstrate that H2S has neuroprotective effects and significantly reduces secondary damage caused by SAH via antioxidant, antiinflammatory, and antiapoptosis mechanisms, and by alleviating cerebral edema and vasospasm. Based on these findings, we believe that H2S has great potential in the treatment of SAH and warrants further study to promote its early clinical application.

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The effect of hydrogen sulphide on experimental cerebral vasospasm

Abstract: ABSTRACTfor calcium (Ca

Cited by 5 publications

References 23 publications

The Potential Role of Hydrogen Sulfide in the Regulation of Cerebrovascular Tone

The Potential Role of Hydrogen Sulfide in the Regulation of Cerebrovascular Tone

Valproic Acid Reduces Vasospasm through Modulation of Akt Phosphorylation and Attenuates Neuronal Apoptosis in Subarachnoid Hemorrhage Rats

Role of hydrogen sulfide in subarachnoid hemorrhage

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