The effect of hyaluronic acid addition to collagen in reducing the trismus and swelling after surgical extraction of impacted lower third molars: a split-mouth, randomized controlled study

Kokash, Moemeneh; Darwich, Khaldoun; Ataya, Jawdat

doi:10.1007/s00784-023-05092-1

Cited by 2 publications

(5 citation statements)

References 28 publications

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“…Another study showed effective reduction of gingival inflammation with an HA and H 2 O 2 mouth rinse [ 14 ]. In TMDs, HA improved maximum mouth opening, reduced pain, and enhanced oral health-related quality of life [ 15 - 20 ]. Additionally, HA reduced postoperative swelling and trismus compared to collagen alone after molar extraction.…”

Section: Resultsmentioning

confidence: 99%

“…The systematic review identified six RCTs exploring the clinical applications of HA in dentistry [ 13 - 15 , 20 , 21 , 24 ]. HA was effective in bone repair post mandibular premolar extraction and improving gingivitis when used in a mouth rinse [ 13 , 14 ].…”

Section: Resultsmentioning

confidence: 99%

“…HA was effective in bone repair post mandibular premolar extraction and improving gingivitis when used in a mouth rinse [ 13 , 14 ]. It served as an adjunct in temporomandibular joint arthroscopy and managed postoperative trismus and swelling [ 15 , 20 ]. HA gel aided in treating chronic periodontitis, especially intra-bony defects, while HA dermal fillers were effective in lip augmentation [ 21 , 24 ] ( Table 2 , Supplementary Material 1 , www.jocmr.org ).…”

Section: Resultsmentioning

confidence: 99%

“…HA’s role extends beyond conventional treatments by addressing oxidative stress and inflammation associated with periodontal disease. Studies included in the review demonstrated HA’s efficacy in enhancing bone formation, reducing gingival inflammation, and managing TMDs, leading to improved mouth opening, pain reduction, and enhanced oral health-related quality of life [ 15 - 20 ]. These findings underscore HA’s therapeutic versatility in dentistry, suggesting its promise not only in treating periodontal defects but also in mitigating systemic inflammatory responses and promoting overall patient well-being.…”

Section: Discussionmentioning

confidence: 99%

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Botulinum Toxin Type A and Hyaluronic Acid Dermal Fillers in Dentistry: A Systematic Review of Clinical Application and Indications

Maci,

Fanelli,

Lorusso

et al. 2024

J Clin Med Res

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Background Botulinum toxin type A (BoNT-A) and hyaluronic acid (HA) dermal fillers are increasingly utilized in dentistry for therapeutic and aesthetic purposes. However, a comprehensive synthesis of their clinical applications and indications in dentistry is lacking. This systematic review aimed to analyze the clinical application and indications of BoNT-A and HA dermal fillers in dentistry, providing insights into their efficacy, safety profiles, and limitations. Methods A systematic search was conducted in PubMed/MEDLINE databases to identify relevant studies published between 2018 and 2024. Medical Subject Headings (MeSH) terms and keywords related to BoNT-A, HA dermal fillers, dentistry, clinical applications, and indications were used. Study selection criteria included randomized controlled trials (RCTs) and non-RCTs involving human participants of any age group. Data extraction and synthesis followed established guidelines, focusing on study characteristics, participant demographics, intervention details, outcome measures, and key findings related to BoNT-A and HA dermal fillers’ clinical application in dentistry. Results Systematic searches across electronic databases and grey literature identified 857 records, with an additional 73 from hand searches. After screening titles and abstracts, 542 records were excluded, leaving 374 full-text publications for evaluation. Ultimately, 12 RCTs and 13 non-RCTs were included. The systematic review encompassed diverse geographic locations: Brazil, Italy, Spain, Syria, India, Egypt, Korea, and the Netherlands, involving samples sizes ranging from 14 to 143 participants. The review synthesized findings on HA’s efficacy in various areas, including bone repair, gingivitis management, temporomandibular joint disorders, postoperative swelling reduction, periodontal defect treatment, chin and check projection and lips augmentation. BoNT-A exhibited promising efficacy in managing orofacial pain conditions, gummy smile treatment and neuromodulation of the lower third muscles. Safety profiles varied among studies, with some reporting minimal adverse effects while others noted dose-related concerns. Conclusion BoNT-A and HA dermal fillers offer a wide array of clinical applications in dentistry, ranging from therapeutic interventions to aesthetic enhancements. Despite promising efficacy, careful consideration and monitoring of safety outcomes are essential when integrating these interventions into clinical practice. Further research addressing methodological limitations and safety concerns is warranted to optimize their utilization and improve patient care in dentistry.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Botulinum Toxin Type A and Hyaluronic Acid Dermal Fillers in Dentistry: A Systematic Review of Clinical Application and Indications

Maci,

Fanelli,

Lorusso

et al. 2024

J Clin Med Res

View full text Add to dashboard Cite

show abstract

“…A total of 20 patients and 40 extractions were calculated as required for this study based on a previously published article [36]. However, based on the usual large flow of patients arriving at the Section of Oral Surgery, Department of Surgical Sciences, University of Turin, a minimum sample size of 35 patients and 70 extractions was calculated to increase the study power.…”

Section: Sample Size Calculationmentioning

confidence: 99%

Hyaluronic Acid Treatment of Post-Extraction Tooth Socket Healing in Subjects with Diabetes Mellitus Type 2: A Randomized Split-Mouth Controlled Study

Ruggiero,

Carossa,

Camisassa

et al. 2024

JCM

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The present study aimed to investigate the effect of HA in improving post-extraction socket healing in subjects with diabetes mellitus (DM) type 2. DM patients requiring bilateral extraction of the homologous teeth were visited at the C.I.R. Dental School, University of Turin. After the extractions, one site was randomly assigned to the test (T) group (postoperative application of HA), while the other site was assigned to the control group (C, no treatment). Patients were then followed after 3, 7, 14, and 21 days. Primary outcomes were the healing index and socket closure. The Mann-Whitney test or the Student’s t-test was used for nonparametric or parametric distributed variables. The chi-square test was used if the estimated data in any given cell were >5, otherwise the Fisher test was adopted. A p < 0.05 was considered statistically significant. In total, 36 patients (n = 36) were enrolled in this study for a total of 72 extractions (n = 72). Sockets treated with HA showed significantly (p < 0.05) better healing index values at day 7 (p = 0.01) and at day 14 (p = 0.02) and significantly (p < 0.05) better socket closure values at day 3 (p = 0.04), day 7 (p = 0.001) and day 14 (p = 0.001) compared to the C group. Based on the clinical results, HA seems to be promising in improving the timing and the quality of post-extractive wound healing in DM patients. Further clinical research, as well as histological investigations, are required to confirm the results.

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The effect of hyaluronic acid addition to collagen in reducing the trismus and swelling after surgical extraction of impacted lower third molars: a split-mouth, randomized controlled study

Cited by 2 publications

References 28 publications

Botulinum Toxin Type A and Hyaluronic Acid Dermal Fillers in Dentistry: A Systematic Review of Clinical Application and Indications

Botulinum Toxin Type A and Hyaluronic Acid Dermal Fillers in Dentistry: A Systematic Review of Clinical Application and Indications

Hyaluronic Acid Treatment of Post-Extraction Tooth Socket Healing in Subjects with Diabetes Mellitus Type 2: A Randomized Split-Mouth Controlled Study

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