The effect of hyaluronic acid on insulin secretion in HIT-T15 cells through the enhancement of gap-junctional intercellular communications

Li, Yuping; Nagira, Tsutomu; Tsuchiya, Toshie

doi:10.1016/j.biomaterials.2005.08.020

Cited by 30 publications

(21 citation statements)

References 17 publications

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“…In a previous study, we demonstrated that a Hya coating promoted several cell functions better than a Hya-supplemented one [25]. Therefore, in this study, we investigated the effects of a SHya coating on keratinocyte differentiation.…”

Section: Introductionmentioning

confidence: 94%

Effects of sulfated hyaluronan on keratinocyte differentiation and Wnt and Notch gene expression

2007

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Section: Introductionmentioning

confidence: 94%

Effects of sulfated hyaluronan on keratinocyte differentiation and Wnt and Notch gene expression

2007

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“…11) were identified more than 30 years ago using electron microscopy (383), and their function first indirectly suggested by two electrode recordings that documented synchronous waves of electrical activity induced by glucose in different cells of the same islet (25,125,247,333,336,350). Further studies showed that in vivo these gap junctions typically comprise small numbers of connexons (341,345) made only of Cx36 in vivo (65,421,478,479,538) within the islets of adult, control animals of all species investigated so far, whereas under certain in vitro conditions they may also contain Cx43 (91,296,309). Cx36 is a 321-amino acid protein with a long (99 amino acid) cytoplasmic loop containing an unusual stretch of 10 glycine residues (94) and a short cytoplasmic COOH-terminal region containing potential recognition sites for casein kinases I and II, cAMP-dependent protein kinase, and calmodulin-dependent protein kinase II (60), consistent with the finding that, at least under certain conditions, the function of Cx36 may be regulated by phosphorylation (3,274,550).…”

Section: B the Connexin And Coupling Patternmentioning

confidence: 99%

Connexins: Key Mediators of Endocrine Function

Bosco

Haefliger

Meda

2011

Physiological Reviews

156

185

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The appearance of multicellular organisms imposed the development of several mechanisms for cell-to-cell communication, whereby different types of cells coordinate their function. Some of these mechanisms depend on the intercellular diffusion of signal molecules in the extracellular spaces, whereas others require cell-to-cell contact. Among the latter mechanisms, those provided by the proteins of the connexin family are widespread in most tissues. Connexin signaling is achieved via direct exchanges of cytosolic molecules between adjacent cells at gap junctions, for cell-to-cell coupling, and possibly also involves the formation of membrane “hemi-channels,” for the extracellular release of cytosolic signals, direct interactions between connexins and other cell proteins, and coordinated influence on the expression of multiple genes. Connexin signaling appears to be an obligatory attribute of all multicellular exocrine and endocrine glands. Specifically, the experimental evidence we review here points to a direct participation of the Cx36 isoform in the function of the insulin-producing β-cells of the endocrine pancreas, and of the Cx40 isoform in the function of the renin-producing juxtaglomerular epithelioid cells of the kidney cortex.

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“…Among its applications, it is widely used as a coating for the surface modification of various biomaterials used for prosthetic cartilage, vascular graft, guided nerve regeneration and drug delivery (Li et al, 2006). Like other glycosaminoglycans, hyaluronan can serve as a targeting vehicle for the delivery of chemotherapeutic agents to cancerous tissues, as many tumours over express the hyaluronan CD44 and RHAMM receptors (Yip et al, 2006).…”

Section: Hyaluronic Acidmentioning

confidence: 99%

“…This growth factor stimulates the proliferation of a wide variety of cells, including mesenchymal, neuroectodermal, and endothelial cells, and it is effective on protecting neurons from oxidative stress processes (Li et al, 2006). However, bFGF has minimal pharmacological effects in the central nervous system (CNS) because of the presence of bloodbrain barrier that reduces its transport to CNS.…”

Section: Group Of Drugsmentioning

confidence: 99%