The effect of Huntington's disease and Gilles de la Tourette's syndrome on the ability to hold and shift attention

Georgiou, Nellie; Bradshaw, Johnson Lockyer; Phillips, James G.; Chiu, Edmond

doi:10.1016/0028-3932(95)00170-0

Cited by 44 publications

(36 citation statements)

References 44 publications

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“…As such, the results of a reduced flanker-N1 between the HD group and the control group are in line with various previous findings of a dysfunction in spatial visual attention in HD (e.g., Finke et al 2006;Georgiou et al 1995Georgiou et al , 1996Georgiou-Karistianis et al 2002;Jahanshahi et al 1993). The fact that the pHD group differed from the HD group suggests that visual attentional processing may decline as disease progresses, and this decline can be assessed neurophysiologically.…”

Section: Attentional Processingsupporting

confidence: 90%

“…Cognitive functions are deteriorated, and tasks measuring attention may allow an adequate assessment of the progression of disease (Lemiere et al 2004). A great deal of evidence indicates that patients with HD show deficits in tasks assessing various processes of spatial and selective visual attention (e.g., Finke et al 2006;Georgiou et al 1995Georgiou et al , 1996GeorgiouKaristianis et al 2002;Jahanshahi et al 1993), and these alterations occur even in presymptomatic HD (pHD) (Lemiere et al 2004).…”

Section: Introductionmentioning

confidence: 99%

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Stimulus-Response Compatibility in Huntington's Disease: A Cognitive-Neurophysiological Analysis

Beste

Saft²,

Andrich³

et al. 2008

Journal of Neurophysiology

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Beste C, Saft C, Andrich J, Gold R, Falkenstein M. Stimulusresponse compatibility in Huntington's disease: a cognitive-neurophysiological analysis. J Neurophysiol 99: 1213-1223, 2008. First published January 9, 2008 doi:10.1152/jn.01152.2007. The basal ganglia are assumed to be of importance in action/response selection, but results regarding the importance are contradictive. We investigate these processes in relation to attentional processing using eventrelated potentials (ERPs) in Huntington's disease (HD), an autosomal genetic disorder expressed by degeneration of the basal ganglia, using a flanker task. A symptomatic HD group, a presymptomatic HD group (pHD), and healthy controls were examined. In the behavioral data, we found a general response slowing in HD while the compatibility effect was the same for all groups. The ERP data show a decrease of the N1 on the flanker in HD and pHD; this suggests deficient attentional processes. The N1 on the target was unaffected, suggesting that the attentional system in HD is not entirely deficient. The early lateralized readiness potential (LRP), reflecting automatic response activation due to the flankers, was unchanged, whereas the late LRP, reflecting controlled response selection due to the target information, was delayed in HD. Thus levels of action-selection processes are differentially affected in HD with automatic processes seeming to be more robust against neurodegeneration. The N2, usually associated with conflict processing, was reduced in the HD but not in the pHD and the control groups. Because the N2 was related to the LRP and reaction times in all groups, the N2 may generally not be related to conflict but rather to controlled response selection, which is impaired in HD. Overall, the results suggest alterations in attentional control, conflict processing, and controlled response selection in HD but not in automatic response selection.

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Section: Attentional Processingsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Stimulus-Response Compatibility in Huntington's Disease: A Cognitive-Neurophysiological Analysis

Beste

Saft²,

Andrich³

et al. 2008

Journal of Neurophysiology

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“…141,173,185 Better performance of both patient groups when external guidance is available may reflect intact passive (exogenous) orienting of attention, which is dependent on posterior cortical regions (Posner's posterior attention system), together with deficient internal control of attention, which is thought to depend on regions of the frontal cortex and basal ganglia (Posner's anterior attention system). 97,[189][190][191][192] HD and PD patients have difficulties, however, with relatively distinct aspects of the internal control of attention. We suggest that difficulties in selfgenerated attention shift, which are observed only in HD patients, result from difficulties in inhibiting or terminating selective attention to a current target, and reflect underactivity of the indirect pathway of the closed associative circuit.…”

Section: Cognitive Symptomsmentioning

confidence: 99%

Open interconnected model of basal ganglia‐thalamocortical circuitry and its relevance to the clinical syndrome of Huntington's disease

Joel

2001

Movement Disorders

145

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The early stages of Huntington's disease (HD) present with motor, cognitive, and emotional symptoms. Correspondingly, current models implicate dysfunction of the motor, associative, and limbic basal ganglia-thalamocortical circuits. Available data, however, indicate that in the early stages of the disease, striatal damage is mainly restricted to the associative striatum. Based on an open interconnected model of basal ganglia-thalamocortical organization, we provide a detailed account of the mechanisms by which associative striatal pathology may lead to the complex pattern of motor, cognitive, and emotional symptoms of early HD. According to this account, the degeneration of a direct and several indirect pathways arising from the associative striatum leads to impaired functioning of: (1) the motor circuit, resulting in chorea and bradykinesia, (2) the associative circuit, resulting in abnormal eye movements, "frontal-like" cognitive deficits and "cognitive disinhibition," and (3) the limbic circuit, resulting in affective and psychiatric symptoms. When relevant, this analysis is aided by comparing the symptomatology of HD patients to that of patients with mild to moderate Parkinson's disease, since in the latter there is similar dysfunction of direct pathways but opposite dysfunction of indirect pathways. Finally, we suggest a potential novel treatment of HD and provide supportive evidence from a rat model of the disease.

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“…Neuropsychological studies consistently showed attentional disinhibition in both clinical populations (Channon et al, 1992;Georgiou et al, 1995Georgiou et al, , 1996Lavoie et al, 2007;Tata et al, 1996;Tolin et al, 2002). In order to extend findings on neuropsychological variables, several studies have recorded Event-Related Potentials (ERPs), which provide indications about cerebral activation in synchrony with cognitive events such as attention, memory (Linden, 2005) and motor functions (Hackley and Valle-Inclan, 2003).…”

Section: Introductionmentioning

confidence: 99%

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

Thibault

Felezeu

O’Connor

et al. 2008

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Approximately 30 to 50% of people suffering from Gilles de la Tourette Syndrome (GTS) also fulfill diagnostic criteria for obsessive-compulsive disorder (OCD). Despite this high degree of comorbidity, very few studies have addressed the question of obsessive-compulsive symptoms (OCS) in GTS patients using specific brain event-related potentials (ERP) responses. The aim of the current study was to quantify neurocognitive aspects of comorbidity, using ERPs. Fourteen adults with GTS (without OCD) were compared to a group of 12 participants with GTS and comorbid obsessive-compulsive symptoms (GTS+OCS), to a group of 15 participants with OCD and to a group of 14 control participants without neurological or psychiatric problems. The P200 and P300 components were recorded during a visual counting oddball task. Results showed intact P200 amplitude in all groups, whilst the P300 amplitude was affected differentially across groups. The P300 oddball effect was reduced in participants in both OCD and GTS+OCS groups in the anterior region. However, the P300 oddball effect was significantly larger in participants of the GTS group compared to all other groups, mostly in the parietal region. These findings suggest that adults with GTS are characterized by enhanced working memory updating processes and that the superimposition of OCS can lead to a reduction of these processes. The discrepancy between our findings and results obtained in previous studies on GTS could reflect the modulating effect of OCS on late ERP components.

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The effect of Huntington's disease and Gilles de la Tourette's syndrome on the ability to hold and shift attention

Cited by 44 publications

References 44 publications

Stimulus-Response Compatibility in Huntington's Disease: A Cognitive-Neurophysiological Analysis

Stimulus-Response Compatibility in Huntington's Disease: A Cognitive-Neurophysiological Analysis

Open interconnected model of basal ganglia‐thalamocortical circuitry and its relevance to the clinical syndrome of Huntington's disease

Influence of comorbid obsessive-compulsive symptoms on brain event-related potentials in Gilles de la Tourette syndrome

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