The effect of humidity on sensitivity of amine detection in ion mobility spectrometry

Mäkinen, Marko; Sillanpää, Mika; Viitanen, Anna-Kaisa; Knap, A.; Mäkelä, Jyrki M.; Puton, Jarosław

doi:10.1016/j.talanta.2010.12.030

Cited by 51 publications

(35 citation statements)

References 24 publications

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“…Remarkably, mobility spectrometers function well across a wide range of humidity levels and temperatures, yet without control of theses parameters, response and reproducibility will be difficult to understand, and comparison between laboratories may be difficult to achieve with a high level of confidence. Although fundamental measurements of association energies of gas phase protons with water molecules were made in the early 1970s 169, 170 , the importance on response has been experimentally explored only in the past two decades for atmospheric pressure ionization (API) MS 171, 172 and only recently for IMS 36, 157, 173–175 .…”

Section: Effects Of Experimental Parametersmentioning

confidence: 99%

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Review on Ion Mobility Spectrometry. Part 2: hyphenated methods and effects of experimental parameters

Cumeras

Figueras

Davis

et al. 2015

Analyst

143

114

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Ion Mobility Spectrometry (IMS) is a widely used and ‘well-known’ technique of ion separation in gaseous phase based on the differences of ion mobilities under an electric field. This technique has received increased interest over the last several decades as evidenced by the pace and advances of new IMS devices available. In this review we explore the hyphenated techniques that are used with IMS, especially mass spectrometry as identification approach and multi-capillary column as pre-separation approach. Also, we will pay special attention to the key figures of merit of the ion mobility spectrum and how data is treated, and the influences of the experimental parameters in both a conventional drift time IMS (DTIMS) and a miniaturized IMS also known as high Field Asymmetric IMS (FAIMS) in the planar configuration. The current review article is preceded by a companion review article which details the current instrumentation and to the sections that configures both a conventional DTIMS and FAIMS devices. Those reviews will give the reader an insightful view of the main characteristics and aspects of the IMS technique.

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Section: Effects Of Experimental Parametersmentioning

confidence: 99%

“…TMA is involved in atmospheric nucleation, i.e. the natural process whereby new particles are generated 175 .…”

Section: Effects Of Experimental Parametersmentioning

confidence: 99%

Review on Ion Mobility Spectrometry. Part 2: hyphenated methods and effects of experimental parameters

Cumeras

Figueras

Davis

et al. 2015

Analyst

143

114

View full text Add to dashboard Cite

show abstract

“…Recently IMS has been applied in the analysis of exhaled air [13][14][15][16][17]. However, the moisture in exhaled air would interfere with the performance of the IMS, such as reducing the selectivity as well as the sensitivity [18,19]. An IMS in combination with a multicapillary column (MCC) was used to measure the propofol concentration in patient's exhaled air by Perl et al and Carstens et al [16,17].…”

Section: Introductionmentioning

confidence: 99%

On-line measurement of propofol using membrane inlet ion mobility spectrometer

Zhou

Wang

Cang

et al. 2012

Talanta

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“…3 Å 2 ) (Table 1). Our calculated CCSs for individual [SDGRG + H] + and [GRGDS + H] + (from pure samples) are within the 3% error range of the previously reported values for the same peptide samples calculated using DTIM-MS. 69 Slight differences in CCS measurements may be due to several factors including (but not limited to) differences in IM cell humidity, 70,71 mixture of gasses between the trap/transfer and IM cells ( i.e ., changing the reduced mass and average drift gas polarizability), 45,69,72–74 accuracy and precision of calibrants’ CCSs, 69 and/or other experimental condition variations. 10 CCSs of deconvoluted [SDGRG + H] + and [GRGDS + H] + without AT corrections were 204.…”

Section: Resultsmentioning

confidence: 99%

Determination of ion mobility collision cross sections for unresolved isomeric mixtures using tandem mass spectrometry and chemometric deconvolution

Harper

Neumann

Stow

et al. 2016

Analytica Chimica Acta

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Ion mobility (IM) is an important analytical technique for determining ion collision cross section (CCS) values in the gas-phase and gaining insight into molecular structures and conformations. However, limited instrument resolving powers for IM may restrict adequate characterization of conformationally similar ions, such as structural isomers, and reduce the accuracy of IM-based CCS calculations. Recently, we introduced an automated technique for extracting “pure” IM and collision-induced dissociation (CID) mass spectra of IM overlapping species using chemometric deconvolution of post-IM/CID mass spectrometry (MS) data [J. Am. Soc. Mass Spectrom., 2014, 25, 1810–1819]. Here we extend those capabilities to demonstrate how extracted IM profiles can be used to calculate accurate CCS values of peptide isomer ions which are not fully resolved by IM. We show that CCS values obtained from deconvoluted IM spectra match with CCS values measured from the individually analyzed corresponding peptides on uniform field IM instrumentation. We introduce an approach that utilizes experimentally determined IM arrival time (AT) “shift factors” to compensate for ion acceleration variations during post-IM/CID and significantly improve the accuracy of the calculated CCS values. Also, we discuss details of this IM deconvolution approach and compare empirical CCS values from traveling wave (TW)IM-MS and drift tube (DT)IM-MS with theoretically calculated CCS values using the projected superposition approximation (PSA). For example, experimentally measured deconvoluted TWIM-MS mean CCS values for doubly-protonated RYGGFM, RMFGYG, MFRYGG, and FRMYGG peptide isomers were 288.8 Å2, 295.1 Å2, 296.8 Å2, and 300.1 Å2; all four of these CCS values were within 1.5% of independently measured DTIM-MS values.

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The effect of humidity on sensitivity of amine detection in ion mobility spectrometry

Cited by 51 publications

References 24 publications

Review on Ion Mobility Spectrometry. Part 2: hyphenated methods and effects of experimental parameters

Review on Ion Mobility Spectrometry. Part 2: hyphenated methods and effects of experimental parameters

On-line measurement of propofol using membrane inlet ion mobility spectrometer

Determination of ion mobility collision cross sections for unresolved isomeric mixtures using tandem mass spectrometry and chemometric deconvolution

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