The effect of human papillomavirus infection on sperm cell motility

Lai, Ying‐Ju; Lee, Jo Fang; Huang, Hsiao‐Ping; Soong, Yung Kuei; Yang, Fengping; Pao, Chia C.

doi:10.1016/s0015-0282(97)81454-9

Cited by 136 publications

(107 citation statements)

References 19 publications

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“…LCS was associated with decreased sperm count, % normal forms and fructose concentration, a measure of seminal vesicle function. Thus, the present study confirms and extends earlier reports that STIs and LCS are associated with poor semen quality (7,13,45,48,49,51,64,65,70,(77)(78)(79)(80)(81)(82).…”

Section: Discussionsupporting

confidence: 92%

“…DNA from HPV 16, 18, 31 and 45 have been associated with invasive squamous cell cancers of the genital tract and anus (66,67). HPV is primarily transmitted through direct epithelial contact (62), but high risk HPV types have been detected in both semen and spermatozoa (68)(69)(70)(71), as well as in the vas deferens (72). In the current report, 3 out of the 8 cases that tested positive for generic HPV DNA were subtyped as HPV-16 (the other 5 cases were indeterminate).…”

Section: Discussionmentioning

confidence: 59%

“…HPV DNA was not associated with LCS but was associated with a significant decrease in total sperm count, and a statistically non-significant trend for lower total motile sperm count and neutral α-glucosidase concentrations. A previous study reported an association between HPV and reduced sperm motility (70), while another study did not find any affects on sperm quality (71). Thus, additional research is needed to determine whether HPV infection contributes to male infertility.…”

Section: Discussionmentioning

confidence: 96%

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Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Bezold

Politch

Kiviat

et al. 2007

Fertility and Sterility

218

167

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Objective-To determine the prevalence of pathogens that cause sexually transmitted infections (STIs) in semen from asymptomatic male infertility patients with and without leukocytospermia (LCS), and associations between STIs, inflammatory markers and other semen variables.Design-Retrospective, controlled study. Results-STI DNA was detected in 45/241 (18.7%) of the samples (CMV 8.7%, HPV 4.5%, HHV-6 3.7%, HSV 3.7%, CT 2.5%, EBV 0.4%, and HBV 0%), with no difference in prevalence between LCS and non-LCS groups. STI DNA in semen was associated with a decrease in sperm concentration, motile sperm concentration, total sperm count and neutral α-glucosidase concentration, whereas LCS was associated with a decrease in total sperm count, % normal forms and fructose concentration. Setting-CenterReprint requests: Deborah J. Anderson, Ph.D., Department of Obstetrics and Gynecology, Boston University School of Medicine, 670 Albany Street, Suite 516, Boston, MA 02118, (FAX: 617-414-8481; e-mail: E-mail: deborah.anderson@bmc.org). Capsule: Sexually transmissible pathogens were detected in 19% of semen samples from infertility patients seeking routine semen analyses; their presence was not associated with leukocytospermia, but was associated with reduced semen quality.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conclusion(s)-STI pathogen DNA was detected in semen from a high percentage of asymptomatic male infertility patients and was associated with poor semen quality. Efforts to diagnose and treat subclinical genital tract infections should be intensified. NIH Public Access

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Bezold

Politch

Kiviat

et al. 2007

Fertility and Sterility

218

167

View full text Add to dashboard Cite

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“…Among 18 large peptides of the proteins E6 and E7, two were recognized in proliferative assays as immunodominant by T cells from 10 out of 16 women (62%) at the entry in the study, namely E6/2 (aa 14-34) and E6/4 (aa peptides. Four other peptides, E6/7 (aa 91-110), E7/2 (aa 7-27), E7/3 (aa [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] and E7/7 (aa 65-87) were recognized by only 12% of the women in proliferative or IFNγ ELISPOT tests. The regions of E6 and E7 proteins implicated in T cell recognition during HPV infection…”

Section: How To Determine the Epitopic Regions For A Therapeutic Vaccmentioning

confidence: 99%

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

Broeck¹

2012

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“…Therefore, sperm may be a site of infection by BPV. The HPV RNA presence was found in human seminal plasma and sperm cells [18]. However, in bovine there is no study about the RNA presence in sperm cells.…”

mentioning

confidence: 95%

Bovine papillomavirus E2 and E5 gene expression in sperm cells of healthy bulls

Silva

Gurgel

et al. 2013

VirusDis.

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Papillomaviruses are found in epithelial lesions and are linked to different carcinogenic processes in humans and other animals. Although BPV has been characterized as epitheliotropic, the presence of viral DNA has been detected in other tissues and fluids, such as fresh semen. The aim of this study was to evaluate the presence and expression of BPV in sperm cells of bulls (Bos taurus) asymptomatic for papillomatosis. A PCR assay was carried out with specific primers to test BPV2 in 26 semen samples. The presence of BPV transcripts was assessed by RT-PCR to E2 and E5 genes. BPV2 DNA was detected in nine out of 26 samples and the expression of E2 and E5 were detected in five out of nine BPV positive samples. This is the first record of BPV2 expression in bull sperm cells.Keywords Bovine papillomavirus Á Semen Á Viral gene expression Papillomaviruses (PVs) are double-stranded DNA tumour viruses identified in a broad range of animal species that belongs to the amniotes, including human being [1]. So far, 13 genotypes of Bovine papillomavirus (BPV1-13) have been characterized [21] and classified in three different genera: Deltapapillomaviruses (BPV1 and 2), Epsilonpapillomaviruses (BPV5 and 8) and Xipapillomaviruses (BPV3, 4, 6, 9, 10 and 11). BPV7 is classified as an unassigned PV genus [12,14]. BPVs from Delta-PVs and BPV5 can infect epithelial and subepithelial fibroblasts inducing fibro-epithelial tumours in cattle, known as fibropapillomas while BPVs from another genus can induce true papillomas [22]. Normally, papillomas regress as a result of cellmediate immune response [17]. However, occasionally papillomas may develop in squamous cell carcinoma as a result of involvement of environmental and genetic cofactors [3,5]. Recently, the co-infection among BPVs in skin lesions (warts) has been described, but the real significance of this finding need to be clarified [7,25,31].PVs are described as epitheliotropic viruses, although their presence has been detected in different tissues and cells [11,20,36]. Few studies have contributed to improved understanding of PV transmission, however, its spread through non-epithelial, however, its spreading of through non-epithelial tissues and fluids has been suggested [6,11].In humans, infected sperm are able to penetrate the oocyte, to deliver HPV genome in the oocyte and HPV genes can be actively transcribed by the fertilized oocyte [10]. There are few reports focusing on the study of BPV in reproductive tract and its cells [13,35] although the BPV-1 were described in the prepuce and penis [16] and BPV-2 were found infecting placenta and actively expressed in equine semen [30,34]. In an early study, we demonstrate the high incidence of BPV2 in commercial doses of bull semen from national and multinational companies [33]. However, studies are needed to understand the biological significance of BPV presence in semen. The present study aimed to evaluate the presence of BPV in sperm cells of healthy bull, as well as the viral gene expression. The semen was collected fro...

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The effect of human papillomavirus infection on sperm cell motility

Cited by 136 publications

References 19 publications

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Prevalence of sexually transmissible pathogens in semen from asymptomatic male infertility patients with and without leukocytospermia

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

Bovine papillomavirus E2 and E5 gene expression in sperm cells of healthy bulls

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