The effect of HSV multiplication rate on antiviral drug efficacy in vitro

Upadhyay, Jagannath; Hill, James M.; Jemison, Michael T.; Helmy, M.F.; Kaufman, Herbert E.

doi:10.1016/0166-3542(91)90041-o

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…One theory is operational latency, which was defined by Kennedy et al as “in the animal model the immediate absence of infectious virus in the cornea or in the TG at the time of sacrifice and the capacity of the excised cornea or TG to produce infectious virus in the cornea after a period of time” [102]. A second theory is that there is a low persistent infection in the cornea, characterized by slow viral replication with small amounts of infectious viral particles released [190]. Detection is not easy with current methods and there are no clinical signs.…”

Section: Latencymentioning

confidence: 99%

Ocular Herpes Simplex Virus: How are Latency, Reactivation, Recurrent Disease and Therapy Interrelated?

et al. 2011

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Most humans are infected with herpes simplex virus (HSV) type 1 in early childhood and remain latently infected throughout life. While most individuals have mild or no symptoms, some will develop destructive HSV keratitis. Ocular infection with HSV-1 and its associated sequelae account for the majority of corneal blindness in industrialized nations. Neuronal latency in the peripheral ganglia is established when transcription of the viral genome is repressed (silenced) except for the latency-associated transcripts and microRNAs. The functions of latency-associated transcripts have been investigated since 1987. Roles have been suggested relating to reactivation, establishment of latency, neuronal protection, antiapoptosis, apoptosis, virulence and asymptomatic shedding. Here, we review HSV-1 latent infections, reactivation, recurrent disease and antiviral therapies for the ocular HSV diseases.

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Section: Latencymentioning

confidence: 99%

Ocular Herpes Simplex Virus: How are Latency, Reactivation, Recurrent Disease and Therapy Interrelated?

et al. 2011

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“…We have shown that the ability of structural cells to replicate virus dif fers among inbred mouse strains [4], Others have reported that the viral replication rate is reduced at lower temperatures (26°C) [22], Upadhyay et al [22] have shown that trifluridine is not effective in suppressing viral replication in Vero cells incubated at 26°C.…”

Section: Discussionmentioning

confidence: 99%

“…It is not known whether this reaction is enzymatic [25]. Dif ferences in the efficacy of ACV in Vero cells and BALB/c and C57BL/6 MEF may be relat ed to differences in the rate of virus replica tion and/or to differences in the levels of metabolism of drug in different cells [22,28,29],…”

Section: Discussionmentioning

confidence: 99%

Effect of Genetically Determined Host Factors on the Efficacy of Vidarabine, Acyclovir and 5-Trifluorothymidine in Herpes simplex Virus Type 1 Infection

Abghari¹,

Stulting²,

Zhu³

et al. 1994

Ophthalmic Res

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The susceptibility of Herpes simplex virus (HSV) to acyclovir (ACV), 5-trifluorothymidine (TFT) and vidarabine (Ara-A) in HSV-infected embryo fibroblasts from BALB/c and C57BL/6 mice as well as Vero cells were measured. Ara-A and TFT (at its highest concentration) were more effective in Vero cells and BALB/c mouse embryo fibroblasts (MEF) than in C57BL/ 6 MEF. In contrast, ACV was more effective in C57BL/6 MEF than BALB/c MEF and Vero cells. These data suggest that genetically determined differences in the ability of host cells to support the replication of HSV influence the activity of antiviral drugs.

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Combination of mutated herpes simplex virus type 1 (G207 virus) with radiation for the treatment of squamous cell carcinoma of the head and neck

Kim¹,

Wong²,

Kooby³

et al. 2005

European Journal of Cancer

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The effect of HSV multiplication rate on antiviral drug efficacy in vitro

Cited by 6 publications

References 15 publications

Ocular Herpes Simplex Virus: How are Latency, Reactivation, Recurrent Disease and Therapy Interrelated?

Ocular Herpes Simplex Virus: How are Latency, Reactivation, Recurrent Disease and Therapy Interrelated?

Effect of Genetically Determined Host Factors on the Efficacy of Vidarabine, Acyclovir and 5-Trifluorothymidine in Herpes simplex Virus Type 1 Infection

Combination of mutated herpes simplex virus type 1 (G207 virus) with radiation for the treatment of squamous cell carcinoma of the head and neck

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