The effect of housing and gender on preference for morphine-sucrose solutions in rats

Hadaway, Patricia F.; Alexander, Bruce; Coambs, Robert B.; Beyerstein, Barry L.

doi:10.1007/bf00431995

Cited by 105 publications

(59 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These results seem, at first sight, contradictory with those of other authors (Alexander et al 1978 ;Hadaway et al 1979;Schenk et al 1987;Consorti et al 1992), showing that isolated rats self-administer or drink more morphine (or of other substances of abuse) than nonisolated animals. However, this contradiction may be only apparent.…”

Section: Discussioncontrasting

confidence: 80%

Isolation impairs place preference conditioning to morphine but not aversive learning in mice

Coudereau

Debray²,

Monier

et al. 1997

Psychopharmacology

View full text Add to dashboard Cite

Morphine (8-100 mg/kg IP) induces place preference conditioning in mice. The effect of two different periods of isolation (15 and 30 days) was examined. Mice isolated for 15 days but not 30 days exhibited place preference conditioning to morphine (8 mg/kg). After 30 days of isolation morphine could not induce place preference conditioning with the following doses (8, 16, 64, 100 mg/kg). Social regrouping of male mice previously isolated for 30 days with naive female mice for 15 or 30 days resulted in a reappearance of the conditioned place preference to morphine (16 mg/kg). The specificity of this associative deficit was examined by testing learning in isolated compared to non-isolated mice in two distinct settings: escape learning in the Morris water maze and passive avoidance acquisition and retention. On the Morris water maze isolated mice did not differ from non-isolated mice regarding place learning, the probe trial or extinction. Isolated mice were unimpaired in passive avoidance acquisition and retention. It was concluded that the deficits in place preference conditioning were not the result of a global learning impairment in isolated mice.

show abstract

Section: Discussioncontrasting

confidence: 80%

Isolation impairs place preference conditioning to morphine but not aversive learning in mice

Coudereau

Debray²,

Monier

et al. 1997

Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Experimental studies have shown that although a higher vulnerability to drug intake is spontaneously observed in certain individuals, it can also be induced by life events and, in particular, by stress. For example, in the rat, only some subjects spontaneously develop amphetamine self-administration (Piazza et al, 1989(Piazza et al, , 1990b, whereas this behavior is enhanced by conditions such as social isolation (Alexander et al, 1978;Hadaway et al, 1979;Schenk et al, 1987;Bozarth et al, 1989), competition in the colony (Maccari et al,199 l), immobilization (Deroche et al, 1992b;Shaham et al, 1992) repeated tail pinch (Piazza et al, 1990a), and prenatal stress (Deminiere et al, 1992). Individual vulnerability and stress-induced predisposition to drug intake are associated with an enhanced locomotor response to psychostimulants, opioids, and novelty (Piazza et al, 1989(Piazza et al, , 1990aHooks et al, 1991;Deroche et al, 1992a), as shown also by the increase in addictive properties of drugs observed when the locomotor effects of psychostimulants and opioids are sensitized (Lett, 1989;Piazza et al, 1990a;Gaiardi et al, 199 1;Horger et al, 199 1) by their repeated injections (for review, see Robinson and Becker, 1986;Kalivas and Stewart, 1991).…”

Section: Studies Of Intravenousmentioning

confidence: 99%

Corticosterone circadian secretion differentially facilitates dopamine- mediated psychomotor effect of cocaine and morphine

et al. 1994

View full text Add to dashboard Cite

Studies of intravenous self-administration and psychomotor effects of drugs have recently suggested that stress-induced corticosterone secretion may be an important factor determining vulnerability to drugs of abuse. In this report, we studied if basal physiological corticosterone secretion modulates sensitivity to cocaine and morphine, and if changes in the reactivity of mesolimbic dopaminergic (DA) neurons, one of the principal substrates of drug-reinforcing effects, are involved. For this purpose we determined the psychomotor effects of these drugs in animals in which corticosterone secretion was suppressed by adrenalectomy and in adrenalectomized animals submitted to different corticosterone replacement therapies designed to mimic (1) only the diurnal levels of the hormone, obtained by the subcutaneous implantation of 50 mg corticosterone pellets; (2) only the nocturnal levels, obtained by adding corticosterone (50 micrograms/ml) to the drinking solution during the dark period; and (3) the entire circadian fluctuation, obtained by combining the two previous treatments. Locomotor response to cocaine and morphine was studied after both systemic and central injections, into the nucleus accumbens for cocaine and into the ventral tegmental area for morphine. These sites were chosen because stimulant effects of cocaine and morphine injected in these structures are dopamine dependent. Our results show that suppression of corticosterone by adrenalectomy reduced the locomotor response to cocaine and morphine, injected both systemically and centrally. The reinstatement of diurnal levels of corticosterone totally reversed adrenalectomy's effects on the behavioral response to cocaine, whereas the reestablishment of the entire corticosterone circadian fluctuation (diurnal plus nocturnal levels) was necessary to reverse the response to morphine.(ABSTRACT TRUNCATED AT 250 WORDS)

show abstract

“…Investigating environmental effects on morphine selfadministration in rats, we found that females consumed more morphine/sucrose solution than males (e.g. Hadaway et al 1979). Eriksson and KAianmaa (1971) reported that female C57BL mice consumed more unadulterated morphine solution than males but did not examine the effects of sweetening the solutions; nor did they compare DBAs of either sex.…”

mentioning

confidence: 99%

Contributions of taste factors and gender to opioid preference in C57BL and DBA mice

1988

View full text Add to dashboard Cite

C57BL/6J and DBA/2J mouse strains have been characterized as morphine preferrers and avoiders, respectively (Horowitz et al. 1977). Previously, sweetened morphine solutions were presented with a water alternative, primarily with male subjects. Because sweetness may affect the endogenous opioid system and rodents have shown strain and sex differences in taste preferences, this study looked for strain- and gender-related taste preferences that might have affected opiate consumption. Preference for sweetened and unsweetened morphine and etonitazene was compared across gender and strain. In all choice tests, the control was a similar tasting quinine sulphate solution. Under these conditions, C57BL/6J mice continued to show strong preference for morphine. However, DBA/2J mice drank approximately equal amounts of morphine and quinine solutions, rather than avoiding morphine as when water was the alternative. Both strains appeared surprisingly indifferent to the synthetic opioid etonitazene, compared because it is potent at concentrations having barely perceptible bitterness. This raises the possibility of unexpected differences in post-ingestional effects between morphine and etonitazene. Contrary to reports of gender differences in sweet preference in rats, none were found in either strain of mouse. Neither were there any significant sex differences in opiate preference in either strain. C57 mice preferred sweetness more than did DBA mice.

show abstract

The effect of housing and gender on preference for morphine-sucrose solutions in rats

Cited by 105 publications

References 21 publications

Isolation impairs place preference conditioning to morphine but not aversive learning in mice

Isolation impairs place preference conditioning to morphine but not aversive learning in mice

Corticosterone circadian secretion differentially facilitates dopamine- mediated psychomotor effect of cocaine and morphine

Contributions of taste factors and gender to opioid preference in C57BL and DBA mice

Contact Info

Product

Resources

About