The effect of HIV infection on the surgical, chemo- and radiotherapy management of breast cancer. A prospective cohort study

Phakathi, Boitumelo; Basson, Gerhard; Karusseit, V.O.L.; Olorunju, Steve; Mokoena, T

doi:10.1016/j.ijsu.2016.08.520

Cited by 18 publications

(25 citation statements)

References 31 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This assumption is supported by three sub‐Saharan African studies, where the HIV prevalence among breast cancer patients was similar to that of the age‐matched source population . These studies were conducted in South Africa, and included patients diagnosed both in the pre‐HAART and post‐HAART era . Lending further plausibility to this assumption, for a given setting, our estimated HIV‐prevalence among breast cancer patients was consistent with the published studies from that sub‐region, as reviewed.…”

Section: Discussionsupporting

confidence: 84%

“…These global estimates of the HIV‐positive breast cancer patient population are subject to an assumption of no HIV‐breast cancer risk association. This assumption is supported by three sub‐Saharan African studies, where the HIV prevalence among breast cancer patients was similar to that of the age‐matched source population . These studies were conducted in South Africa, and included patients diagnosed both in the pre‐HAART and post‐HAART era .…”

Section: Discussionmentioning

confidence: 83%

“…To estimate HIV‐positive breast cancers, the primary method assumed no association, either direct or indirect, between HIV and breast cancer risk for a given country and age stratum. This assumption was made because breast cancer is not a HIV‐associated cancer; several studies in HIV‐endemic areas have shown that the HIV prevalence among breast cancer patients is similar to that of the age‐matched source population . However, US investigations have shown a deficit of breast cancer in WLWAH, which could not be explained by potential differences in reproductive or other lifestyle factors.…”

Section: Methodsmentioning

confidence: 99%

“…Notably, between 1991–1995 and 2001–2005, there was a 10‐fold increase in the absolute number of breast cancers in the US AIDS population (men and women) . HIV‐positive breast cancer patients have also been documented in South Africa, including within a 2007–2011 breast cancer case series in Soweto's Chris Hani Baragwanath Academic Hospital which included 151 women co‐affected by HIV and breast cancer . The HIV‐positive breast cancer patient population is expected to further increase in absolute size over the coming decades, assuming that access to HAART continues.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Breast cancer in women living with HIV: A first global estimate

McCormack

Febvey-Combes

Ginsburg

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

There is a growing population of older women living with HIV/AIDS (WLWHA). Breast cancer is a common cancer in women worldwide, but the global number of breast cancers in WLWHA is not known. We estimated, for each UN sub-region, the number and age distribution of WLWHA who were diagnosed with breast cancer in 2012, by combining IARC-GLOBOCAN estimates of age-country specific breast cancer incidence with corresponding UNAIDS HIV prevalence. Primary analyses assumed no HIV-breast cancer association, and a breast cancer risk reduction scenario was also considered. Among 16.0 million WLWHA aged 15+ years, an estimated 6,325 WLWHA were diagnosed with breast cancer in 2012, 74% of whom were in sub-Saharan Africa, equally distributed between Eastern, Southern and Western Africa. In most areas, 70% of HIV-positive breast cancers were diagnosed under age 50. Among all breast cancers (regardless of HIV status), HIV-positive women constituted less than 1% of the clinical burden, except in Eastern, Western and Middle Africa where they comprised 4-6% of under age 50 year old breast cancer patients, and in Southern Africa where this patient subgroup constituted 26 and 8% of breast cancers diagnosed under and over age 50 respectively. If a deficit of breast cancer occurs in WLWHA, the global estimate would reduce to 3,600. In conclusion, worldwide, the number of HIV-positive women diagnosed with breast cancer was already substantial in 2012 and with an expected increase within the next decade, early detection and treatment research targeted to this population are needed.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 83%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Breast cancer in women living with HIV: A first global estimate

McCormack

Febvey-Combes

Ginsburg

et al. 2018

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

“…Less is known about LMIC and especially about head and neck surgery in the surgical mission setting. Asymptomatic HIV did not adversely affect surgical outcomes in a South African study of breast cancer surgery . On the other hand, there was a high rate of graft failure (75%) and persistent otorrhea in highly active anti‐retrovirus therapy (HAART)‐treated HIV+ children compared to a similar HIV‐group in one Ethiopian mission‐based study .…”

Section: Introductionmentioning

confidence: 94%

Reducing Surgical Site Infections During Otolaryngology Surgical Missions

2019

View full text Add to dashboard Cite

Objectives:To determine what measures an otolaryngology-head and neck surgery team might adopt to decrease the incidence of surgical site infection (SSI) on a short-term surgical mission. Despite concerns about safety and efficacy, shortterm surgical missions remain the predominant structure for humanitarian surgical care in low-and middle-income countries (LMIC). Hospitals in high-income countries strive to improve surgical outcomes through implementation of World Health Organization (WHO) safe surgery guidelines. Reduction of SSI risk is a key part of this effort.Methods: Literature review and practical experience.Results: WHO recommendations for reducing SSI are based largely on research done in the North America and Europe. LMIC populations are younger; comorbidities are fewer; infectious disease and trauma are prevalent; and delays in access to care are common. SSI are much more frequent in resource-limited settings. Recommendations regarding preoperative assessment, operating room environment, instrument sterilization, surgical antibiotic prophylaxis, surgical site preparation, gloving, draping, and postsurgical care are reviewed in the context of a surgical mission at a typical LMIC government hospital.Conclusion: Many of the WHO guidelines on reduction of SSI are logical and applicable to the short-term surgical missions; others may need to be modified. Careful prospective data collection and clinical trials are needed to learn which interventions are valid and which should be changed.

show abstract

Three‐year survival of breast cancer patients attending a one‐stop breast care clinic nested within a primary care health facility in sub‐Saharan Africa‐Zambia

Songiso,

Nuñez,

Cabanes

et al. 2024

Intl Journal of Cancer

View full text Add to dashboard Cite

In Zambia, women with breast symptoms travel through multiple levels of the healthcare system before obtaining a definitive diagnosis. To eradicate this critical barrier to care, we nested a novel breast specialty service platform inside a large public‐sector primary healthcare facility in Lusaka, Zambia to offer clinical breast examination, breast ultrasound, and ultrasound‐guided core needle biopsy in a one‐stop format, tightly linked to referral for treatment. The objective of the study was to determine the life expectancy and survival outcomes of a prospective cohort of women diagnosed with breast cancer who were attended to and followed up at the clinic. The effect of breast cancer stage on prognosis was determined by estimating stage‐specific crude survival using the Kaplan–Meier method. Survival analysis was used to estimate mean lifespan according to age and stage at diagnosis. We enrolled 302 women with histologically confirmed breast cancer. The overall 3‐year survival was 73%. An increase in patients presenting with early breast cancer and improvements in their survival were observed. Women with early‐stage breast cancer had a lifespan similar to the general population, while loss of life expectancy was significant at more advanced stages of disease. Our findings suggest that implementing efficient breast care services at the primary care level can avert a substantial proportion of breast cancer‐related deaths. The mitigating factor appears to be stage of disease at the time of diagnosis, the cause of which is multifactorial, with the most influential being delays in the referral process.

show abstract

The effect of HIV infection on the surgical, chemo- and radiotherapy management of breast cancer. A prospective cohort study

Cited by 18 publications

References 31 publications

Breast cancer in women living with HIV: A first global estimate

Breast cancer in women living with HIV: A first global estimate

Reducing Surgical Site Infections During Otolaryngology Surgical Missions

Three‐year survival of breast cancer patients attending a one‐stop breast care clinic nested within a primary care health facility in sub‐Saharan Africa‐Zambia

Contact Info

Product

Resources

About