The effect of histological chorioamnionitis on the short-term outcome of preterm infants ≤32 weeks: a single-center study

Arayıcı, Sema; Şimşek, Gülsüm Kadıoğlu; Öncel, Mehmet Yekta; Eras, Zeynep; Canpolat, Fuat Emre; Oğuz, Şerife Suna; Uraş, Nurdan; Zergeroğlu, Sema; Dilmen, Uğur

doi:10.3109/14767058.2013.850668

Cited by 50 publications

(35 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In human studies, chorioamnionitis has been associated with neonatal death (27,86), early-onset neonatal sepsis (86)(87)(88), intrauterine growth restriction (89), poor neonatal growth (90), neurologic impairment/injury (91,92), intraventricular hemorrhage (86), bronchopulmonary dysplasia (93)(94)(95), patent ductus arteriosus (86,89,93,96), retinopathy of prematurity (89,97,98), cardiovascular abnormalities (99, 100), necrotizing enterocolitis (101,102), and dermatitis (103). However, low gestational age is often a significant contributing factor (104)(105)(106), and therefore, it is difficult to attribute these sequelae solely to chorioamnionitis.…”

Section: Neonatal Sequelae Of Chorioamnionitismentioning

confidence: 99%

The Human Ureaplasma Species as Causative Agents of Chorioamnionitis

et al. 2017

View full text Add to dashboard Cite

SUMMARY The human Ureaplasma species are the most frequently isolated microorganisms from the amniotic fluid and placentae of women who deliver preterm and are also associated with spontaneous abortions or miscarriages, neonatal respiratory diseases, and chorioamnionitis. Despite the fact that these microorganisms have been habitually found within placentae of pregnancies with chorioamnionitis, the role of Ureaplasma species as a causative agent has not been satisfactorily explained. There is also controversy surrounding their role in disease, particularly as not all women infected with Ureaplasma spp. develop chorioamnionitis. In this review, we provide evidence that Ureaplasma spp. are associated with diseases of pregnancy and discuss recent findings which demonstrate that Ureaplasma spp. are associated with chorioamnionitis, regardless of gestational age at the time of delivery. Here, we also discuss the proposed major virulence factors of Ureaplasma spp., with a focus on the multiple-banded antigen (MBA), which may facilitate modulation/alteration of the host immune response and potentially explain why only subpopulations of infected women experience adverse pregnancy outcomes. The information presented within this review confirms that Ureaplasma spp. are not simply “innocent bystanders” in disease and highlights that these microorganisms are an often underestimated pathogen of pregnancy.

show abstract

Section: Neonatal Sequelae Of Chorioamnionitismentioning

confidence: 99%

The Human Ureaplasma Species as Causative Agents of Chorioamnionitis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…The current study also identified a trend between maternal inflammatory response increasing RDS and culture positive sepsis, as well as a significant correlation between culture-positive sepsis and subacute or necrotizing acute chorioamnionitis. The relationship between neonatal sepsis and chorioamnionitis has previously been established [4; 33]. …”

Section: Discussionmentioning

confidence: 99%

Correlation of preterm infant illness severity with placental histology

et al. 2016

View full text Add to dashboard Cite

show abstract

“…For 39 infants born <32 weeks gestation who were exposed to CA compared to 33 control infants, there was no difference between groups in mental and psychomotor developmental indices. 31 Similarly, a case control study found no difference in performance on the Bayley Scales of Infant Development between the 71 infants exposed and the 259 infants not exposed to CA at 7 months corrected age. 30 …”

Section: Neonatal Outcomesmentioning

confidence: 95%

“…30 For infants <32 weeks gestational age, 145 infants exposed to histologic CA developed clinical criteria consistent with sepsis syndrome significantly more often than 136 infants without CA, 39% vs 24% (p=0.007). 31 …”

Section: Neonatal Outcomesmentioning

confidence: 99%

Chorioamnionitis

Ericson

Laughon

2015

Clinics in Perinatology

View full text Add to dashboard Cite

Chorioamnionitis (CA) is a perinatal condition characterized by inflammation of the fetal membranes. The incidence of CA increases with decreasing gestational age at birth. When CA is suspect based on clinical criteria, pathologic assessment of the placenta should be performed. While the mechanisms are not entirely clear, CA predisposes infants to premature birth, neonatal sepsis and intraventricular hemorrhage. The role of CA in respiratory distress syndrome, bronchopulmonary dysplasia, and neurodevelopmental impairment is mixed. Prevention and treatment of CA are not well defined. The use of antibiotics for preterm premature rupture of membranes reduces the incidence of CA and increases the length of time to delivery. Antibiotics are recommended for infants exposed to CA while laboratory studies are being performed.

show abstract

The effect of histological chorioamnionitis on the short-term outcome of preterm infants ≤32 weeks: a single-center study

Abstract: Maternal histological CA is an important risk factor for preterm deliveries and associated with serious morbidities such as early onset sepsis, IVH, PDA and increased mortality.

Cited by 50 publications

References 29 publications

The Human Ureaplasma Species as Causative Agents of Chorioamnionitis

The Human Ureaplasma Species as Causative Agents of Chorioamnionitis

Correlation of preterm infant illness severity with placental histology

Chorioamnionitis

Contact Info

Product

Resources

About